Abstract
A large variety of hormones and neurotransmitters transmit their regulatory signals into target cells via stimulation or inhibition of adenylate cyclase and the consequent increase or decrease of intracellular cyclic AMP levels. Because of the importance of adenylate cyclase as a signal transduction system, interest in adenylate cyclase has centered on the mechanisms and components involved in its hormonal control. The complete transduction system is composed of at least the specific stimulatory and inhibitory hormone receptors, the adenylate cyclase itself and two guanine nucleotide-binding, regulatory components, Ns and Ni, which act as coupler between stimulatory and inhibitory hormone receptors, respectively, and adenylate cyclase (1,2). Both types of hormones, adenylate cyclase stimulatory and inhibitory, have been shown to stimulate GTPase(s) in membrane preparations. In this review, the role of this hormone-stimulated GTP hydrolysis in the bidirectional regulation of adenylate cyclase will be considered.
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Aktories, K., Schultz, G., Jakobs, K.H. (1984). Role of Hormone-Sensitive GTPases in Adenylate Cylase Regulation. In: Kito, S., Segawa, T., Kuriyama, K., Yamamura, H.I., Olsen, R.W. (eds) Neurotransmitter Receptors. Advances in Experimental Medicine and Biology, vol 175. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-4805-4_3
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