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Neurotransmitter Receptors pp 221–233Cite as

Purification of γ-Aminobutyric Acid (GABA) and Benzodiazepine Receptors from Rat Brain Using Benzodiazepine-Affinity Column Chromatography

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 175))

Abstract

γ-Aminobutyric acid (GABA) has been established as a major inhibitory neurotransmitter in the mammalian central nervous system (1–4) as well as invertebrate nervous systems (5,6). GABA acts through a physiologically relevant receptor protein, the GABA receptor, which is labeled specifically by [3H]GABA (7) and various GABA agonists such as [3H]muscimol (8,9). On the other hand, it has been demonstrated that specific and pharmacologically relevant benzodiazepine receptors exist in the mammalian central nervous system (10,11).

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Authors and Affiliations

  1. Department of Pharmacology, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamikyo-Ku Kyoto 602, Japan

    Kinya Kuriyama & Jun-ichi Taguchi

Authors
  1. Kinya Kuriyama
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  2. Jun-ichi Taguchi
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Editor information

Editors and Affiliations

  1. Third Department of Internal Medicine, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minamiku, Hiroshima 734, Japan

    Shozo Kito M.D., Ph.D.

  2. Department of Pharmacology Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minamiku, Hiroshima 734, Japan

    Tomio Segawa Ph.D.

  3. Department of Pharmacology, Kyoto Prefectural University of Medicine, Kawaramachi, Hirokoji, Kamikyoku Kyoto 602, Japan

    Kinya Kuriyama M.D.

  4. Departments of Pharmacology, Biochemistry, Psychiatry and the Arizona Research Laboratories, University of Arizona Health Sciences Center, 85724, Tucson, Arizona, USA

    Henry I. Yamamura Ph.D.

  5. Department of Pharmacology, University of California, Los Angeles School of Medicine, 90024, Los Angeles, California, USA

    Richard W. Olsen Ph.D.

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© 1984 Plenum Press, New York

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Kuriyama, K., Taguchi, Ji. (1984). Purification of γ-Aminobutyric Acid (GABA) and Benzodiazepine Receptors from Rat Brain Using Benzodiazepine-Affinity Column Chromatography. In: Kito, S., Segawa, T., Kuriyama, K., Yamamura, H.I., Olsen, R.W. (eds) Neurotransmitter Receptors. Advances in Experimental Medicine and Biology, vol 175. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-4805-4_18

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  • DOI: https://doi.org/10.1007/978-1-4684-4805-4_18

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  • Print ISBN: 978-1-4684-4807-8

  • Online ISBN: 978-1-4684-4805-4

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