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Ca2+-Activated, Fatty Acid-Dependent Guanylate Cyclase in Synaptic Plasma Membranes and Its Requirement for Ca2+ and Mg-GTP in the Activation

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Book cover Neurotransmitter Receptors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 175))

Abstract

Cyclic GMP in an intact cell system was reported to increase by various biologically active compounds, including muscarinic cholinergic agonists and excitatory amino acids, and supposed to act as intracellular messenger of the various neurotransmitters and hormones. Guanylate cyclase, a cyclic GMP-generating enzyme, in a cell free system can not be stimulated by agents increasing cyclic GMP contents. This suggests that the cyclase is activated by a substance generated or a process taking place within cells upon hormone stimulation. Thus cellular components such as Ca2+, fatty acids and their metabolites that are intracellularly liberated on the stimulation have been supposed to be possible physiological activators of guanylate cyclase in intact cells.

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Author information

Authors and Affiliations

  1. Department of Pharmacology, Saga Medical School Nabeshima, Nabeshima-machi, Saga, 840-01, Japan

    Takeo Asakawa, Masako Takano, Keiichi Enomoto & Kazuko Hayama

Authors
  1. Takeo Asakawa
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  2. Masako Takano
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  3. Keiichi Enomoto
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  4. Kazuko Hayama
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Editor information

Editors and Affiliations

  1. Third Department of Internal Medicine, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minamiku, Hiroshima 734, Japan

    Shozo Kito M.D., Ph.D.

  2. Department of Pharmacology Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minamiku, Hiroshima 734, Japan

    Tomio Segawa Ph.D.

  3. Department of Pharmacology, Kyoto Prefectural University of Medicine, Kawaramachi, Hirokoji, Kamikyoku Kyoto 602, Japan

    Kinya Kuriyama M.D.

  4. Departments of Pharmacology, Biochemistry, Psychiatry and the Arizona Research Laboratories, University of Arizona Health Sciences Center, 85724, Tucson, Arizona, USA

    Henry I. Yamamura Ph.D.

  5. Department of Pharmacology, University of California, Los Angeles School of Medicine, 90024, Los Angeles, California, USA

    Richard W. Olsen Ph.D.

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© 1984 Plenum Press, New York

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Asakawa, T., Takano, M., Enomoto, K., Hayama, K. (1984). Ca2+-Activated, Fatty Acid-Dependent Guanylate Cyclase in Synaptic Plasma Membranes and Its Requirement for Ca2+ and Mg-GTP in the Activation. In: Kito, S., Segawa, T., Kuriyama, K., Yamamura, H.I., Olsen, R.W. (eds) Neurotransmitter Receptors. Advances in Experimental Medicine and Biology, vol 175. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-4805-4_14

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  • DOI: https://doi.org/10.1007/978-1-4684-4805-4_14

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-4807-8

  • Online ISBN: 978-1-4684-4805-4

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