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Evidence for Alpha2 Adrenergic Receptors in Bovine Cerebral Arteries

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Book cover Neurotransmitter Receptors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 175))

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Abstract

Adrenergic innervation to cerebral arteries is thought to play an important role in controlling cerebral blood flow (1). Histochemical studies have revealed high concentrations of norepinephrine and rich adrenergic innervation from the superior cervical ganglion in the adventitia and outer border of the medial layer of cerebral arteries in various species (2,3). Isolated cerebral arteries are contracted by alpha adrenergic agonists in a dose dependent manner and this contraction is blocked by alpha adrenergic antagonists (4,5). Alpha adrenergic receptors have been classified into alpha and alpha2 subtypes (6,7). Sakakibara et al. (8) suggested that contraction of the isolated dog basilar artery is mediated by alpha receptors. In the present study, we attempted to characterize alph2 adrenergic receptors in bovine cerebral arteries using an alpha1 antagonist, [3H]prazosin and an alpha2 antagonist, [3H]yohimbine.

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Author information

Authors and Affiliations

  1. Department of Pharmacology Faculty of Medicine, Kyoto University, Kyoto 606, Japan

    Takashi Taniguchi & Motohatsu Fujiwara

  2. Department of Neurosurgery Faculty of Medicine, Kyoto University, Kyoto 606, Japan

    Tetsuya Tsukahara & Hajime Handa

Authors
  1. Takashi Taniguchi
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  2. Motohatsu Fujiwara
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  3. Tetsuya Tsukahara
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  4. Hajime Handa
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Editor information

Editors and Affiliations

  1. Third Department of Internal Medicine, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minamiku, Hiroshima 734, Japan

    Shozo Kito M.D., Ph.D.

  2. Department of Pharmacology Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minamiku, Hiroshima 734, Japan

    Tomio Segawa Ph.D.

  3. Department of Pharmacology, Kyoto Prefectural University of Medicine, Kawaramachi, Hirokoji, Kamikyoku Kyoto 602, Japan

    Kinya Kuriyama M.D.

  4. Departments of Pharmacology, Biochemistry, Psychiatry and the Arizona Research Laboratories, University of Arizona Health Sciences Center, 85724, Tucson, Arizona, USA

    Henry I. Yamamura Ph.D.

  5. Department of Pharmacology, University of California, Los Angeles School of Medicine, 90024, Los Angeles, California, USA

    Richard W. Olsen Ph.D.

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© 1984 Plenum Press, New York

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Taniguchi, T., Fujiwara, M., Tsukahara, T., Handa, H. (1984). Evidence for Alpha2 Adrenergic Receptors in Bovine Cerebral Arteries. In: Kito, S., Segawa, T., Kuriyama, K., Yamamura, H.I., Olsen, R.W. (eds) Neurotransmitter Receptors. Advances in Experimental Medicine and Biology, vol 175. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-4805-4_10

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  • DOI: https://doi.org/10.1007/978-1-4684-4805-4_10

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-4807-8

  • Online ISBN: 978-1-4684-4805-4

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