Abstract
It has been well established that human foods may contain trace amounts of carcinogenic N-nitrosamines. Originally, it was thought that the use of nitrite as a curing agent for flesh foods was the major source of these trace compounds in the diet. Subsequent research has clearly shown that other processing and packaging procedures can also introduce trace amounts of these carcinogens into foods. These procedures include drying foods in direct flame heated air, migration from food contact surfaces and direct addition as contaminants. In addition, other reports of N-nitrosamines in foods have less well defined routes of contamination. These sources of N-nitrosamines in foods will each be briefly reviewed in this paper and recent data from our laboratory concerning N-nitrosamines in products which directly contact foods presented. We also are reporting the N-nitrosothiazolidine content of fried-out bacon fat.
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References
Anon., 1980, Investigations on formation and occurrence of volatile nitrosamines in Danish cheese, The Government Research Institute for Dairy Industry and The National Food Institute, Denmark.
Babish, J. G., Hotchkiss, J. H., Wachs, T., Vecchio, A. J., Gutenmann, W. H., and Lisk, D. J., 1982, N-nitrosamines in rubber nursing nipples, J. Toxicol. Environ. Health (in press).
Bharucha, K. R., Cross, C. K., and Rubin, L. J., 1979, Mechanism of N-nitrosopyrrolidine formation in bacon, J. Agric. Food Chem, 27: 63.
Challis, B. C., and Kyrtopoulos, S. A., 1978, The chemistry of nitroso compounds. Part 12. The mechanism of nitrosation and nitration of aqueous piperidine by gaseous dinitrogen tetroxide and dinitrogen trioxide, J. Chem. Soc. Perkin II, 1978: 1296.
Dean-Raymond, D., and Alexander, M., 1976, Plant uptake and leaching of dimethylnitrosamine, Nature, 262: 394.
Digenis, G. A., and Issidorides, C. H., 1979, Some biochemical aspects of N-nitroso compounds, Bioorg. Chem 8: 97.
Ender, F., Harve, G., Helgebostad, A., Koppang, N., Madsen, R., and Ceh, L., 1964, Isolation and identification of a hepatotoxic factor in herring meal produced from sodium nitrite preserved herring, Naturwissenschaften, 51: 637.
Fazio, T., and Havery, D. C., 1981, Volatile N-nitrosamines in direct flame dried processed foods, in: “Proceedings of the Seventh International Meeting on N-nitroso Compounds: Occurrence and Biological Effects”, (in press) International Agency for Research on Cancer, Lyon.
Fine, D. H., and Rounbehler, D. P., 1981, Occurrence of N-nitrosamines in the workplace: Some recent developments, in: “N-nitroso Compounds,” R. A. Scanlan and S. R. Tannenbaum, eds., American Chemical Society, Washington, D.C.
Fishbein, L., 1979, Overview of some aspects of occurrence, formation, and analysis of nitrosamines, Sci. Total Environ, 13: 157.
Fridman, A. L., Mukhametshin, F. M., and Novikov, S. S., 1971, Advances in the chemistry of aliphatic N-nitrosamines, Russ. Chem. Rev, 40: 34.
Gray, J. I., 1976, N-nitrosamines and their precursors in bacon: A review, J. Milk Food Technol, 39: 686.
Gray, J. I., and Randall, C. J., 1979, The nitrite/nitrosamine problem in meats: An update, J. Food Protect, 42: 168.
Gray, J. I., 1981, Formation of N-nitroso compounds in foods, in: “N-nitroso Compounds,” R. A. Scanlan and S. R. Tannenbaum, eds., American Chemical Society, Washington, D.C.
Gray, J. I., Reddy, S. K., Price, J. F., Mandagere, A., and Wilkens, W. F., 1982, Inhibition of N-nitrosamines in Bacon, Food Technology, 36 (6): 39.
Hansen, T., Iwaoka, W., Green, L., and Tannenbaum, S. R., 1977, Analysis of N-nitrosoproline in raw bacon: Further evidence that nitrosoproline is not a major precursor of nitrosopyrrolidine, J. Agric. Food Chem, 25: 1423.
Havery, D. C., Fazio, T., and Howard, J. W., 1978, Trends in levels of N-nitrosopyrrolidine in fried bacon, J. Assoc. Off. Anal. Chem, 61: 1379.
Havery, D. C., Hotchkiss, J. H., and Fazio, T., 1981, Nitrosamines in malt and malt beverages, J. Food Sci, 46: 501.
Havery, D. C., and Fazio, T., 1982, Estimation of volatile N-nitrosamines in baby bottle rubber nipples, Food Chem. Toxicol, (in press).
Hoffmann, D., Brunnemann, K. D., Adams, J. D., Rivenson, A., and Hecht, S. S., 1982, N-nitrosamines in tobacco carcinogenesis, in: “Banbury Report 12: Nitrosamines and Human Cancer,” (in press) Cold Spring Harbor Laboratory, Cold Spring Harbor.
Hotchkiss, J. H., Barbour, J. F., Scanlan, R. A., 1980, Analysis of malted barley for N-nitrosodimethylamine, J. Agric Food Chem, 28: 680.
Hotchkiss, J. H., 1981, Analytical methodology for sample preparation, detection, quantitation, and confirmation of N-nitrosamines in foods, J. Assoc. Offic. Anal. Chem, 64: 1037.
Hotchkiss, J. H., and Vecchio, A. J., 1982, Analysis of direct contact paper and paperboard food packaging for N-nitrosomorpholine and morpholine, J. Food Sci., (in press).
Kann, J., Tauts, O., Kalve, R., Bogovski, P., 1980, Potential formation of N-nitrosamines in the course of technological processing of some foodstuffs, in: “N-nitroso Compounds: Analysis, Formation and Occurrence,” E. A. Walker, L. Griciute, M. Castegnaro, and M. Borzsonyi, eds., International Agency for Research on Cancer, Lyon.
Khan, S. U., 1981, N-nitrosamine formation in soil from the herbicide glyphosate and its uptake by plants, in: “N-nitroso Compounds,” R. A. Scanlan and S. R. Tannenbaum, eds., American Chemical Society, Washington, D.C.
Kimoto, W. I., Dooley, C. J., Carre, J., and Fiddler, W., 1980, Role of strong anion exchange resins in nitrosamine formation in water, Water Res, 14: 869.
Kimoto, W. I., Pensabene, J. W., and Fiddler, W., 1982, Isolation and identification of N-nitrosothiazolidine in fried bacon, J. Agric. Food Chem, 30: 757.
Lakritz, L., and Pensabene, J. W., 1981, Survey of fluid and nonfat dry milks for N-nitrosamines, J. Dairy Sci, 64: 371.
Libbey, L. M., Scanlan, R. A., and Barbour, J. F., 1980, N-nitrosodimethylamine in dried dairy products, Food Cosmet. Toxicol, 18: 459.
Mangino, M. M., Scanlan, R. A., and O’Brien, T. J., 1981, N-nitro- samines in beer, in: “N-nitroso Compounds,” R. A. Scanlan and S. R. Tannenbaum, eds., American Chemical Society, Washington, D.C.
Matsui, M., Ohshima, H., and Kawabata, T., 1980, Increase in the nitrosamine content of several fish products upon broiling, B. Japan Soc. Sci. Fisheries, 46: 587.
Mihara, S., and Shibamoto, T., 1980, Mutagenicity of products obtained from cysteamine-glucose browning model systems, J. Agric. Food Chem, 28: 62.
Mirvish, S.S., 1975, Formation of N-nitroso compounds: Chemistry, Kinetics and in vivo occurrence, Toxicol. Appl. Pharm, 31: 325.
Mumma, R. 0., Raupach, D. R., Waldman, J. P., Tong, S. S. C., Jacobs, M. L., Hotchkiss, J. H., Babish, J. G., Van Campen, D. R., Wszolek, P. C., Gutenmann, W. H., Bache, C. A., and Lisk, D. J., 1982, National survey of elements and other constituents in municipal sewage sludges, Environ. Sci. Technol. (submitted).
Nakamura, M., Baba, N., Nakaoka, T., Wada, Y., Ishibash, T., and Kawabata, T., 1976, Pathways of formation of N-nitrosopyrrolidine in fried bacon, J. Food Sci, 41: 874.
Oliver, J. E., 1981, Pesticide-derived nitrosamines: Occurrence and environmental fate, in: “N-nitroso Compounds,” R. A. Scanlan and S. R. Tannenbaum, eds., American Chemical Society, Washington, D.C.
Preussmann, R., Spiegelhalder, B., and Eisenbrand, G., 1981, Reduction of human exposure to environmental N-nitroso compounds, in: “N-nitroso Compounds,” R. A. Scanlan and S. R. Tannenbaum eds., American Chemical Society, Washington, D.C.
Ross, R. D., Morrison, J., Rounbehler, D. P., Fan, T. Y., and Fine, D. H., 1977, N-nitroso compound impurities in herbicide formulations, J, Agric. Food Chem, 25: 1416.
Ross, R., Morrison, J., and Fine, D. H., 1978, Assessment of dipropylnitrosamine levels in a tomato field following application of treflan EC, J. Agric. Food Chem, 26: 455.
Scanlan, R. A., 1975, N-nitrosamines in foods, CRC Crit. Rev. Food Sci. Technol, 5: 357
Sekizawa, J., and Shibamoto, T., 1980, Mutagenicity of 2-alkyl-N-nitrosothiazolidines, J. Agric. Food Chem, 28: 781.
Sen, N. P., Donaldson, B., Charbonneau, C., Miles, W. F., 1974, Effect of additives on the formation of nitrosamines in meat curing mixtures containing spices and nitrites, J. Agric. Food Chem 22: 1125.
Sen, N. P., Donaldson, B. A., Seaman, S. Iyengar, J. R., Miles, W. F., 1978, Recent studies in Canada on the analysis and occurrence of volatile and nonvolatile N-nitroso compounds in foods, in: “Environmental Aspects of N-nitroso Compounds”, E.A. Walker, M. Castegnaro, L. Griciute, and R. E. Lyle, eds. International Agency for Research on Cancer, Lyon.
Sen, N. P., and Seaman, S., 1981, Volatile N-nitrosamines in dried foods, J. Assoc. Off. Anal. Chem, 64: 1238.
Spiegelhalder, B., Eisenbrand, G., and Preussmann, R., 1979, Contamination of beer with trace quantities of N-nitrosodimethylamine, Food Cosmet. Toxicol, 17: 29.
Spiegelhalder, B., Eisenbrand, G., Preussmann, R., 1980, Volatile nitrosamines in food, Oncology, 37: 211.
Spiegelhalder, B., and Preussmann, R., 1981, Nitrosamines and rubber in: “Proceedings of the Seventh International Meeting on N-nitroso Compounds: Occurrence and Biological Effects,” (in press) International Agency for Research on Cancer, Lyon.
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Hotchkiss, J.H. (1984). Sources of N-Nitrosamine Contamination in Foods. In: Friedman, M. (eds) Nutritional and Toxicological Aspects of Food Safety. Advances in Experimental Medicine and Biology, vol 177. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4790-3_14
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DOI: https://doi.org/10.1007/978-1-4684-4790-3_14
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