Structure and Stereochemistry of Steroidal Amine Teratogens

  • William Gaffield
  • Richard F. Keeler
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 177)


Studies of teratogenic steroidal alkaloids from Veratrum and Solanum have shown that those bearing a basic nitrogen atom in ring F, shared or unshared with ring E, with bonding capabilities a to the steroid plane may be suspect as teratogens. Examples of steroidal alkaloids which produce terata but, until recently, have been of uncertain structure include muldamine and the isomeric 3, N-diformylsolasodines. The correlation of their structures with the structure-terata relationship developed by Keeler and Brown is discussed. A brief introduction to teratogenicity is presented.


Spina Bifida Steroidal Alkaloid Bonding Capability Basic Nitrogen Atom Uncertain Structure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • William Gaffield
    • 1
  • Richard F. Keeler
    • 2
  1. 1.Western Regional Research Center, ARSUSDABerkeleyUSA
  2. 2.Poisonous Plant Research Laboratory, ARSUSDALoganUSA

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