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In Vitro Modulation of Epstein-Barr Virus-Carrying Lymphoblastoid Cell Lines

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Immune Deficiency and Cancer

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Abstract

The B-lymphocytes are natural target cells for Epstein-Barr virus (EBV) infection. In vivo they may be infected after clinically inapparent entry of the virus into a child or in teen-age children and young adults. Infectious mononucleosis (IM) results in 50% of cases (32,70). The infected lymphocytes are immortalized, transformed into lymphoblasts and a few cells persist in the infected individuals for life (22). They contain, as a rule, multiple copies of the viral genome (3) and express an EBV-determined DNA-binding nuclear-associated antigen (EBNA) (52,72).

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  1. Department of Experimental Virology, Institute of Sera and Vaccines, 108 W. Pieck Street, 101 03, Prague 10, Czechoslovakia

    Jaroslav Roubal, Emma Anisimová & Kateřina Prachová

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  1. University of Nebraska Medical Center, Omaha, Nebraska, USA

    David T. Purtilo

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Roubal, J., Anisimová, E., Prachová, K. (1984). In Vitro Modulation of Epstein-Barr Virus-Carrying Lymphoblastoid Cell Lines. In: Purtilo, D.T. (eds) Immune Deficiency and Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4760-6_9

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