Abstract
Understanding the cellular response to ionizing radiation is not only necessary to meet the requirements of radioprotection, but also for medical application of radiation in cancer treatment. In terms of radiobiology, cancer therapy means the selective inactivation of malignant cells without affecting the normal healthy tissue. However, for several physical and biological reasons, this ideal situation is normally not attained. The elaboration of biophysical parameters that could be used to improve the selective sterilization of tumor cells has become one of the main activities of cellular radiobiology during the last two decades. Progress in this field has been facilitated by the development of tissue culture techniques allowing to grow and analyze cells in a synthetic nutrient medium.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
T.T. Puck and P.I. Marcus, J. Exptl. Med. 103; 653 (1956).
M.M. Elkind and C.F. Whitmore, “The Radiobiology of Cultured Mammalian Cells”, Gordon and Breach, Science Publishors, New York — London — Paris (1967).
D.E. Lea, “Actions of Radiations on Living Cells”, Cambridge University Press (1962).
H. Dertinger and H. Jung, “Molecular Radiation Biology, Springer-Verlag” New York — Berlin — Heidelberg (1970).
H.S. Kaplan and L.E. Moses, Science 145; 21 (1964).
J.B. Little, Radiat. Res. 56: 320 (1973).
H.R. Withers, Radiat. Res. 71; 24 (1977).
T. Coquerelle, A. Bopp, B. Kessler and U. Hagen, Int. J. Radiat. Biol. 24; 397 (1972).
G. Ahnstrom and K. Edvardsson, Int. J. Radiat. Biol. 26: 493 (1974).
K.F. Weibenzahn and T.M. Coquerelle, Nucl. Acids Res. 9: 3139 (1981).
R.B. Painter and B.R. Young, Mutat. Res. 14: 225 (1972).
P.C. Hanawalt, P.K. Cooper, A.K. Ganesan and C.A. Smith, Ann. Rev. Biochem. 48: 783 (1979).
R.B. Painter, in: “Radiation Biology in Cancer Research”, R.E. Meyn and H.R. Withers, ed. Raven Press, New York, p. 59 (1980).
H.J. Rahmsdorf, H. Ponta, M. Baechle, U. Mallick, K.F. Weibezahn and P. Herrlich, Exptl. Cell Res. (1981).
T.M. Coquerelle, and K.F. Weibezahn, Radiat. Res. 87: 472 (1981).
F. Laval, Proc. Natl. Acad. Sci. U.S.A. 77: 2702 (1980).
A.B. Pardee, R. Dubrow, I.L. Hamlin and R.F. Kletzien, Ann. Rev. Biochem. 47: 715 (1978).
R.M. Liskay and D.M. Prescott, Proc. Natl. Acad. Sci. U.S.A. 75: 2873 (1978).
R.D. Romberg and A. Klug, Scient. Am. 244: 48 (1981).
M.R. Melamed, P.F. Mullaney and M.L. Mendelson, “Flow Cytometry and Sorting”, John Wiley and Sons, New York — Chichester — Brisbane — Toronto (1979).
C. Lucke-Huhle, E.A. Blakely, P.Y. Chang and C.A. Tobias, Radiat. Res. 79: 97 (1979).
W.K. Sinclair, Radiat. Res. 33: 620 (1968).
M. Wannenmacher, E. Esser, J. Glupe and I. Schumann, Strahlentherapie 147: 1 (1974).
A.E. Howes and H.D. Suit, Radiat. Res. 57: 342 (1974).
L.A. Staehelin and B.E. Hull, Scient. Am. 238: 140 (1978).
D.F. Hulser and D.J. Webb, Exptl. Cell. Res. 80: 210 (1973).
W.W. Stewart, Nature 292: 17 (1981).
W.R. Loewenstein and Y. Kanno, J. Cell Biol. 33: 225 (1967).
A. Amsterdam, M. Knecht and K. Catt, Proc. Natl. Acad. Sci. U.S.A. 78: 3000 (1981).
S. Chung, S.M. Landfear, D.D. Blumberg, N.S. Cohen and H.F. Lodish, Cell 24: 785 (1981).
H. Dertinger and C. Lucke-Huhle, Int. J. Radiat. Biol. 28: 255 (1975).
H. Dertinger and D. Hulser, Radiat. Environ. Biophys. 19: 101 (1981).
J. Midander, P.J. Deschavanne, E.P. Malaise and L. Revesz, Int. J. Radiat. Oncol. Suppl. (1981).
L.H. Gray, Am. J. Roentgenol. 85: 803 (1961).
H.S. Kaplan, Europ. J. Cancer 10: 275 (1974).
E.J. Hall, “Radiobiology for the Radiologist”, Harper and Row Publishers, Hagerstown — Maryland — New York — Evanston — San Francisco and London (1978).
G.W. Barendsen, H.M. Walter, J.F. Fowler and D.K. Bewley, Radiat. Res. 18: 106 (1963).
P. Todd, Radiat. Res. 34: 378 (1968).
R.P. Bird and H.J. Burki, Int. J. Radiat. Biol. 27: 105 (1975).
M.R.Raju, H.I.Amols, E.Bain, S.G.Carpenter, R.A.Cox and J.B.Robertson, Brit. J. Radiol. 51: 712 (1978).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Plenum Press, New York
About this chapter
Cite this chapter
Dertinger, H. (1984). Biophysics of Radiation Action. In: Khan, A.M., Riazuddin, S., Qadir, A., Qazi, M.N. (eds) Physics and Contemporary Needs. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4724-8_16
Download citation
DOI: https://doi.org/10.1007/978-1-4684-4724-8_16
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-4726-2
Online ISBN: 978-1-4684-4724-8
eBook Packages: Springer Book Archive