Skip to main content
SpringerLink
Log in

Time-Resolved Laser Fluorescence and Photobleaching of Single Cells after Photosensitization with Hematoporphyrin Derivative (HpD)

  • Chapter
Porphyrins in Tumor Phototherapy

Abstract

Because of its preferential retention in tumor cells hematopor-phyrin derivative (HpD) is used for diagnosis1,2 and phototherapy 3 of tumors. The cytotoxic effect has been attributed to the formation of singlet oxygen after intermolecular energy transfer HpD→O2 4 or to the production of HpD radicals 5.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. A. E. Profia, D. R. Doiron, and E. G. King, Laser fluorescence bronchoscope for localization of occult lung tumors, Med. Phys. 6:523 (1979).

    Article  Google Scholar 

  2. J. H. Kinsey, D. A. Cortese, and D. R. Sanderson: Mayo Clin. Proc. 53:593 (1978).

    Google Scholar 

  3. T. J. Dougherty, J. E. Kaufman, A. Goldfbar, K. R. Weishaupt, D. Boyle, and A. Mittleman, Photoradiation therapy for the treatment of malignant tumors, Cancer Res. 38:2628 (1978).

    Google Scholar 

  4. K. R. Weishaupt, Ch. J. Gomer, and T. J. Dougherty, Identification of singlet oxygen as cytotoxic agent photoinactivation of murine tumor, Cancer Res. 36:2326 (1979).

    Google Scholar 

  5. A. Andreoni, R. Cubeddu, S. De Silvestri, P. Laporta, and O. Svelto, Two step laser activation of Hematoporphyrin Derivative, Chem. Phys. Lett. 88:37 (1982).

    Article  Google Scholar 

  6. F. Docchio, R. Ramponi, C. A. Sacchi, G. Bottiroli, and I. Freitas, Fluorescence studies of biological molecules by laser irradiation, in: “New Frontiers in Laser Medicine and Surgery”, K. Atsumi, ed., Excerpta Medica, Amsterdam-Oxford--Princeton (1983).

    Google Scholar 

  7. D. Jocham, E. Unsöld, G. Staehler, and Ch. Chaussy, Proc. Symp. Porphyrin Localizatin and Treatment of Tumors (St. Barbara, USA) (1983).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Abteilung f. Angewandte Optik, Gesellschaft f. Strahlen- und Umweltforschung mbH München, Ingolstädter Landstr. 1, D-8042, Neuherberg, F.R. Germany

    H. Schneckenburger, E. Unsöld, W. Weinsheimer & D. Jocham

  2. Urologische Klinik und Poliklinik, Klinikum Großhadern, Marchioninistr. 15, D-8000, München 70, F.R.Germany

    W. Weinsheimer & D. Jocham

Authors
  1. H. Schneckenburger
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. Unsöld
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. W. Weinsheimer
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. D. Jocham
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. The Polytechnic Institute of Milan, National Research Council, Milan, Italy

    Alessandra Andreoni  & Rinaldo Cubeddu  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Plenum Press, New York

About this chapter

Cite this chapter

Schneckenburger, H., Unsöld, E., Weinsheimer, W., Jocham, D. (1984). Time-Resolved Laser Fluorescence and Photobleaching of Single Cells after Photosensitization with Hematoporphyrin Derivative (HpD). In: Andreoni, A., Cubeddu, R. (eds) Porphyrins in Tumor Phototherapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4721-7_15

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-4721-7_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4723-1

  • Online ISBN: 978-1-4684-4721-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation