Abstract
The Pseudomonas putida plasmid pAC25 specifies an inducible 3-chlorobenzoic acid degradation pathway. 3-iodobenzoic acid is a poor substrate and fails to induce the enzymes of this pathway, even though 3-fluorobenzoic acid and 3-bromobenzoic acid can both serve as inducers and are good substrates. Through chemostatic selection we have isolated a derivative of pAC25 with altered regulation and substrate specificity such that 3-iodobenzoic acid can now serve as a sole carbon and energy source.
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© 1984 Plenum Press, New York
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Kilbane, J.J., Chakrabarty, A.M. (1984). Evolution of New Degradative Functions for Halogenated Aromatics. In: Omenn, G.S., et al. Genetic Control of Environmental Pollutants. Basic Life Sciences, vol 28. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4715-6_28
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DOI: https://doi.org/10.1007/978-1-4684-4715-6_28
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-4717-0
Online ISBN: 978-1-4684-4715-6
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