Skip to main content
SpringerLink
Log in

Regulation of Natural Killer Cell Activity

  • Chapter
Biological Responses in Cancer

Abstract

Natural killer (NK) cells have cytotoxic activity against a variety of tumor cells and also against some microorganisms or cells infected by microbial agents (for comprehensive review and detailed information, see Herberman and Holden, 1978, and Herberman, 1980, 1982). They may thereby serve as important effector cells in host resistance against disease. NK cells are present in virtually all individuals and can be activated rapidly by a wide variety of stimuli, and their activities do not depend on sensitization by antigens and the development of specific immune responses. Thus, these cells may function as a first line of defense against attack by neoplastic cells or infectious agents.

This review is dedicated to the memory of the late Gustavo Cudkowicz, a colleague and close friend who made pioneering observations on natural host resistance and on the negative regulation of mouse natural killer cell activity by suppressor cells.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Allavena, P., Introna, M., Mangioni, C., and Mantovani, A., 1981, Inhibition of natural killer activity by tumor-associated lymphoid cells from ascitic ovarian carcinomas, J. Natl. Cancer Inst. 67:319–325.

    PubMed  CAS  Google Scholar 

  • Biondi, A., Bordignon, C., Peri, G., Donati, M. B., Vicenzi, E., Ghezzi, P., Salmona, M., and Mantovani, A., 1983, Regulation of the tumoricidal and suppression activity of human macrophages, in: Advances in Immunopharmacology 2 (J. W. Hadden, L. Chedid, P. Dukor, F. Spreafico, and D. Willoughby, eds.), Pergamon Press, Oxford, pp. 251–256.

    Google Scholar 

  • Biron, C. A., and Welsh, R. M., 1982, Proliferation and role of natural killer cells during viral infection, in: NK Cells and Other Natural Effector Cells (R. B. Herberman, ed.), Academic Press, New York, pp. 493–498.

    Chapter  Google Scholar 

  • Bordignon, C., Villa, F., Allavena, P., Introna, M., Biondi, A., Avallone, R., and Mantovani, A., 1982, Inhibition of natural killer activity by human bronchoalveolar macrophages, J. Immunol. 129:587–591.

    PubMed  CAS  Google Scholar 

  • Brunda, M. J., Herberman, R. B., and Holden, H. T., 1980a, Inhibition of murine natural killer cell activity by prostaglandins, J. Immunol. 124:2682–2687.

    PubMed  CAS  Google Scholar 

  • Brunda, M. J., Herberman, R. B., and Holden, H. T., 1980b, Interferon-independent activation of murine natural killer cell activity, in: Natural Cell-Mediated Immunity Against Tumors (R. B. Herberman, ed.), Academic Press, New York, pp. 525–528.

    Google Scholar 

  • Brunda, M. J., Herberman, R. B., and Holden, H. T., 1981, Antibody-induced augmentation of murine natural killer cell activity, Int. J. Cancer 27:205–211.

    Article  PubMed  CAS  Google Scholar 

  • Brunda, M. J., Taramelli, D., Holden, H. T., and Varesio, L., 1982, Suppression of murine natural killer cell activity by normal peritoneal macrophages, in: NK Cells and Other Natural Effector Cells (R. B. Herberman, ed.), Academic Press, New York, pp. 535–540.

    Chapter  Google Scholar 

  • Burton, R. C., 1980, Alloantisera selectively reactive with NK cells: Characterization and use in defining NK cell classes, in: Natural Cell-Mediated Immunity Against Tumors (R. B. Herberman, ed.), Academic Press, New York, pp. 19–35.

    Google Scholar 

  • Cudkowicz, G., and Hochman, P. S., 1979, Do natural killer cells engage in regulated reactions against self to ensure homeostasis? Immunol. Rev. 44:13–52.

    Article  PubMed  CAS  Google Scholar 

  • D’Amore, P. J., Golightly, M. G., and Golub, S. H., 1982, Heterogeneity of MLC-generated NK-like cells, in: NK Cells and Other Natural Effector Cells (R. B. Herberman, ed.), Academic Press, New York, pp. 785–790.

    Chapter  Google Scholar 

  • deLandazuri, M. O., Silva, A., Alvarez, J., and Herberman, R. B., 1979, Evidence that natural cytotoxicity and antibody dependent cellular cytotoxicity are mediated in humans by the same effector cell populations, J. Immunol. 123:252–258.

    CAS  Google Scholar 

  • deLandazuri, M. O., Lopez-Botet, M., Timonen, T., Ortaldo, J. R., and Herberman, R. B., 1981, Human large granular lymphocytes: Spontaneous and interferon-boosted NK activity against adherent and nonadherent tumor cell lines, J. Immunol. 127:1380–1383.

    CAS  Google Scholar 

  • deVries, J. E., Figdor, C. G., and Spits, H., 1982, Regulation of human NK activity against adherent tumor target cells by monocyte subpopulations, interleukin-1, and interferons, in: NK Cells and Other Natural Effector Cells (R. B. Herberman, ed.), Academic Press, New York, pp. 657–668.

    Chapter  Google Scholar 

  • Djeu, J. Y., Heinbaugh, J. A., Holden, H. T., and Herberman, R. B., 1979a, Augmentation of mouse natural killer cell activity by interferon and interferon inducers, J. Immunol. 122:175–181.

    PubMed  CAS  Google Scholar 

  • Djeu, J. Y., Heinbaugh, J., Vieira, W. D., Holden, H. T., and Herberman, R. B., 1979b, The effect of immunopharmacological agents on mouse natural cell-mediated cytotoxicity and on its augmentation by poly I:C, Immunopharmacology 1:131–144.

    Article  Google Scholar 

  • Djeu, J. Y., Huang, K.-Y., and Herberman, R. B., 1980, Augmentation of mouse natural killer activity and induction of interferon by tumor cells in vivo, J. Exp. Med. 151:781–789.

    Article  PubMed  CAS  Google Scholar 

  • Djeu, J. Y., Hapel, A. J., and Ihle, J. N., 1982, Natural cytotoxic activity of mouse spleen cell cultures maintained with interleukin-3, in: NK Cells and Other Natural Effector Cells (R. B. Herberman, ed.), Academic Press, New York, pp. 917–921.

    Chapter  Google Scholar 

  • Domzig, W., and Stadler, B. M., 1982, The relation between human natural killer cells and interleukin-2, in: NK Cells and Other Natural Effector Cells (R. B. Herberman, ed.), Academic Press, New York, pp. 409–414.

    Chapter  Google Scholar 

  • Droller, M. J., Schneider, M. V., and Perlmann, P., 1978, A possible role of prostaglandins in the inhibition of natural and antibody-dependent cell-mediated cytotoxicity against tumor cells, Cell. Immunol. 39:165–172.

    Article  PubMed  CAS  Google Scholar 

  • Einhorn, S., Ahre, A., Blomgren, H., Johansson, B., Mellstedt, H., and Strander, H., 1982, Enhanced NK activity in patients treated by interferon-α: Relation to clinical response, in: NK Cells and Other Natural Effector Cells (R. B. Herberman, ed.), Academic Press, New York, pp. 1259–1263.

    Chapter  Google Scholar 

  • Epstein, L. B., and Bourne, H. R., 1976, Interferon production by mitogen stimulated lymphocytes: Cyclic AMP mediated inhibition by cholera toxin, in: Mitogens in Immunobiology (D. Rosenstreich and J. Oppenheim, eds.), Academic Press, New York, pp. 136–145.

    Google Scholar 

  • Eremin, O., 1980, NK cell activity in the blood, tumor-draining lymph nodes and primary tumors of women with mammary carcinoma, in: Natural Cell-Mediated Immunity Against Tumors (R. B. Herberman, ed.), Academic Press, New York, pp. 1011–1027.

    Google Scholar 

  • Gerson, J. M., 1980, Systemic and in situ natural killer activity in tumor-bearing mice and patients with cancer, in: Natural Cell-Mediated Immunity Against Tumors (R. B. Herberman, ed.), Academic Press, New York, pp. 1047–1062.

    Google Scholar 

  • Gerson, J. M., Varesio, L., and Herberman, R. B., 1981, Systemic and in situ natural killer and suppressor cell activities in mice bearing progressively growing murine sarcoma-virus induced tumors, Int. J. Cancer 27:243–248.

    Article  PubMed  CAS  Google Scholar 

  • Gidlund, M., Örn, A., Wigzell, H., Senik, A., and Gresser, I., 1978, Enhanced NK cell activity in mice injected with interferon and interferon inducers, Nature 223:259–261.

    Google Scholar 

  • Goldfarb, R. H., and Herberman, R. B., 1981, Natural killer cell reactivity: Regulation interactions among phorbol ester, interferon, cholera toxin, and retinoic acid, J. Immunol. 126:2129–2135.

    PubMed  CAS  Google Scholar 

  • Goldfarb, R. H., and Herberman, R. B., 1982, Inhibition of natural killer cell cytotoxicity reactivity by tumor promoters and cholera toxin, in: NK Cells and Other Natural Effector Cells (R. B. Herberman, ed.), Academic Press, New York, pp. 595–600.

    Chapter  Google Scholar 

  • Golub, S. H., 1982, NK cytotoxicity in interferon treated melanoma patients, in: NK Cells and Other Natural Effector Cells (R. B. Herberman, ed.), Academic Press, New York, pp. 1265–1271.

    Chapter  Google Scholar 

  • Goto, T., Herberman, R. B., Maluish, A., and Strong, D. M. 1983, Cyclic AMP as a mediator of prostaglandin E-induced suppression of human natural killer cell activity, J. Immunol. 130:1350–1355.

    PubMed  CAS  Google Scholar 

  • Grimm, E., and Bonavida, B., 1979, Mechanism of cell-mediated cytotoxicity at the single cell level. I. Estimation of cytotoxic T lymphocyte frequency and relative lytic efficiency, J. Immunol. 123:2861–2869.

    PubMed  CAS  Google Scholar 

  • Grollman, E. F., Lee, G., Ramos, S., Lazo, P. S., Kaback, R., Friedman, R., and Kohn, L., 1978, Relationship of the structure and function of the interferon receptors to hormone receptors and establishment of the anti-viral state, Cancer Res. 38:4172–4181.

    PubMed  CAS  Google Scholar 

  • Hecker, E., 1971, Isolation and characterization of the co-carcinogenic principle from croton oil, Meth. Cancer Res. 6:439–484.

    CAS  Google Scholar 

  • Hellström, K. E., and Hellström, L, 1974, Lymphocyte-mediated cytotoxicity and blocking serum activity to tumor antigens, Adv. Immunol. 18:209–277.

    Article  PubMed  Google Scholar 

  • Henney, C. S., Gaffney, J., and Bloom, R. B., 1974, On the relation of products of activated lymphocytes to cell-mediated cytolysis, J. Exp. Med. 140:837–843.

    Article  PubMed  CAS  Google Scholar 

  • Henney, C. S., Tracey, D., Durdik, J. M., and Klimpel, G., 1978, Natural killer cells in vitro and in vivo, Am. J. Pathol. 93:459–468.

    PubMed  CAS  Google Scholar 

  • Herberman, R. B., 1974, Cell mediated immunity to tumor cells, in: Advances in Cancer Research, Volume 19 (G. Klein and S. Weinhouse, eds.), Academic Press, New York, pp. 207–263.

    Chapter  Google Scholar 

  • Herberman, R. B. (ed.), 1980, Natural Cell-Mediated Immunity Against Tumors, Academic Press, New York.

    Google Scholar 

  • Herberman, R. B. (ed.), 1982, NK Cells and Other Natural Effector Cells, Academic Press, New York.

    Google Scholar 

  • Herberman, R. B., and Holden, H. T., 1978, Natural cell-mediated immunity, Adv. Cancer Res. 27:305–377.

    Article  PubMed  CAS  Google Scholar 

  • Herberman, R. B., Nunn, M. E., Holden, H. T., and Lavrin, D. H., 1975a, Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. II. Characterization of effector cells, Int. J. Cancer 16:230–239.

    Article  PubMed  CAS  Google Scholar 

  • Herberman, R. B., Nunn, M. E., and Lavrin, D. H., 1975b, Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. I. Distribution of reactivity and specificity, Int. J. Cancer 16:216–229.

    Article  PubMed  CAS  Google Scholar 

  • Herberman, R. B., Bartram, S., Haskill, J. S., Nunn, M., Holden, H. T., and West, W. H., 1977a, Fc receptors on mouse effector cells mediating natural cytotoxicity against tumor cells, J. Immunol. 119:322–326.

    PubMed  CAS  Google Scholar 

  • Herberman, R. B., Nunn, M. E., Holden, H. T., Staal, S., and Djeu, J. Y., 1977b, Augmentation of natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic target cells, Int. J. Cancer 19:555–564.

    Article  PubMed  CAS  Google Scholar 

  • Herberman, R. B., Holden, H. T., West, W. H., Bonnard, G. D., Santoni, A., Nunn, M. E., Kay, H. D., and Ortaldo, J. R., 1979a, Cytotoxicity against tumors by NK and K cells, in: Tumor-Associated Antigens and Their Specific Immune Responses (F. Spreafico and R. Arnon, eds.), Academic Press, London, pp. 129–150.

    Google Scholar 

  • Herberman, R. B., Ortaldo, J. R., and Bonnard, G. D., 1979b, Augmentation by interferon of human natural and antibody-dependent cell-mediated cytotoxicity, Nature 277:221–223.

    Article  PubMed  CAS  Google Scholar 

  • Herberman, R. B., Ortaldo, J. R., Rubinstein, M., and Pestka, S., 1981, Augmentation of natural and antibody-dependent cell-mediated cytotoxicity by pure human leukocyte interferon, J. Clin. Immunol. 1:149–153.

    Article  PubMed  CAS  Google Scholar 

  • Herberman, R. B., Brunda, M. J., Domzig, W., Fagnani, R., Goldfarb, R. H., Holden, H. T., Ortaldo, J. R., Reynolds, C. W., Riccardi, C., Santoni, A., Stadler, B. M., Taramelli, D., Timonen, T., and Varesio, L., 1982a, Immunoregulation involving macrophages and natural killer cells, in: The Biological Significance of Immune Regulation (M. E. Gershwin and L. N. Ruben, eds.), Marcel Dekker, New York, pp. 139–166.

    Google Scholar 

  • Herberman, R. B., Ortaldo, J. R., Mantovani, A., Hobbs, D. S., Kung, H.-F., and Pestka, S., 1982b, Effect of human recombinant interferon on cytotoxic activity of natural killer (NK) cells and monocytes, Cell. Immunol. 67:160–167.

    Article  PubMed  CAS  Google Scholar 

  • Hersey, P., Edwards, A., Edwards, J., Adams, E., Milton, G. W., and Nelson, D. S., 1975. Specificity of cell-mediated cytotoxicity against human melanoma lines: Evidence for “nonspecific” killing by activated T-cells, Int. J. Cancer 16:173–183.

    Article  PubMed  CAS  Google Scholar 

  • Hiserodt, J. C., Britvan, L. J., and Targan, S. R., 1982, Characterization of the cytolytic reaction mechanism of the human natural killer (NK) lymphocyte: Resolution into binding, programming, and killer cell-independent steps, J. Immunol. 129:1782–1787.

    PubMed  CAS  Google Scholar 

  • Hochman, P. S., and Cudkowicz, G., 1979, Suppression of natural cytotoxicity by spleen cells of hydrocortisone-treated mice, J. Immunol. 123:968–976.

    PubMed  CAS  Google Scholar 

  • Hochman, P. S., Cudkowicz, G., and Dausset, J., 1978, Decline of natural killer cell activity in sublethally irradiated mice, J. Natl. Cancer Inst. 61:265–268.

    PubMed  CAS  Google Scholar 

  • Hochman, P. S., Cudkowicz, G., and Evans, P. D., 1981, Carrageenan-induced decline of natural killer activity. II. Inhibition of cytolysis by adherent non-T la-negative suppressor cells activated in vivo, Cell. Immunol. 61:200–212.

    Article  PubMed  CAS  Google Scholar 

  • Hostetter, R. K., and Cooper, E. L., 1972, Coelomocytes as effector cells in earthworm immunity, Immunol. Commun. 1:155–183.

    PubMed  CAS  Google Scholar 

  • Ito, M., Ralph, P., and Moore, M. A. S., 1980, Suppression of spleen natural killing activity induced by BCG, Clin. Immunol. Immunopathol. 16:30–38.

    Article  PubMed  CAS  Google Scholar 

  • Kay, H. D., Fagnani, R., and Bonnard, G. D., 1979, Cytotoxicity against the K562 erythroleukemia cell line by human natural killer (NK) cells which do not bear free Fc receptors for IgG, Int. J. Cancer 42:141–150.

    Article  Google Scholar 

  • Keller, R., 1979, Suppression of natural antitumor defence mechanisms by phorbol esters, Nature 282:729–731.

    Article  PubMed  CAS  Google Scholar 

  • Kendall, R. A., and Targan, S., 1980, The dual effect of prostaglandin (PGE2) and ethanol in the natural killer cytolytic process: Effector activation and NK-target cell conjugate lytic inhibition, J. Immunol. 125:2770–2777.

    PubMed  CAS  Google Scholar 

  • Kiessling, R., Klein, E., and Wigzell, H., 1975a, “Natural” killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype, Eur. J. Immunol. 5:112–117.

    Article  PubMed  CAS  Google Scholar 

  • Kiessling, R., Klein, E., Pross, H., and Wigzell, H., 1975b, “Natural” killer cells in the mouse. II. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Characterization of the killer cell, Eur. J. Immunol. 5:117–121.

    Article  PubMed  CAS  Google Scholar 

  • Kim, Y. B., Huh, N. D., Koren, H. S., and Amos, D. B., 1980, Natural killing (NK) and antibodydependent cellular cytotoxicity (ADCC) in specific pathogen-free (SPF) miniature swine and germfree piglets. I. Comparison of NK and ADCC, J. Immunol. 125:755–762.

    PubMed  CAS  Google Scholar 

  • Koren, H. S., and Jensen, P. J., 1980, Natural killing and antibody-dependent cellular cytotoxicity: Independent mechanisms mediated by overlapping cell populations, in: Natural Cell-Mediated Immunity Against Tumors (R. B. Herberman, ed.), Academic Press, New York, pp. 347–363.

    Google Scholar 

  • Koren, H. S., Anderson, S. J., Fischer, D. G., Copeland, C. S., and Jensen, P. J., 1981, Regulation of human natural killing. I. The role of monocytes, interferon, and prostaglandins, J. Immunol. 127:2007–2012.

    PubMed  CAS  Google Scholar 

  • Kumagai, K., Itoh, K., Suzuki, R., Hinuma, S., and Saitoh, F., 1982, Studies of murine large granular lymphocytes. I. Identification as effector cells in NK and K cytotoxicities, J. Immunol. 129:388–394.

    PubMed  CAS  Google Scholar 

  • Kuribayashi, K., Gillis, S., Kern, D. E., and Henney, C. S., 1981, Murine NK cell cultures: Effects of interleukin-2 and interferon on cell growth and cytotoxic reactivity, J. Immunol. 126:2321–2327.

    PubMed  CAS  Google Scholar 

  • Lang, N. P., Ortaldo, J. R., Bonnard, G. D., and Herberman, R. B., 1982, Interferon and prostaglandins: Effects on human natural and lectin-induced cytotoxicity, J. Natl. Cancer Inst. 69:339–343.

    PubMed  CAS  Google Scholar 

  • Lanza, E., and Djeu, J. Y., 1982, Age-independent natural killer cell activity in murine peripheral blood, in: NK Cells and Other Natural Effector Cells (R. B. Herberman, ed.), Academic Press, New York, pp. 335–340.

    Chapter  Google Scholar 

  • Lattime, E. C., Pecoraro, G. A., Cuttito, M., and Stutman, O., 1982, Solid tumors are killed by NK and NC cell populations: Interferon inducing agents do not augment NC cell activity under NK activating conditions, in: NK Cells and Other Natural Effector Cells (R. B. Herberman, ed.), Academic Press, New York, pp. 179–186.

    Chapter  Google Scholar 

  • Leung, K. H., and Koren H. S., 1982, Regulation of human natural killing. II. Protective effect of interferon on NK cells from suppression of PGE2, J. Immunol. 129:1742–1747.

    PubMed  CAS  Google Scholar 

  • Lotzová, E., 1980, C. parvum-mediated suppression of the phenomenon of natural killing and its analysis, in: Natural Cell-Mediated Immunity Against Tumors (R. B. Herberman, ed.), Academic Press, New York, pp. 735–752.

    Google Scholar 

  • Lotzová, E., and Gutterman, J. V., 1979, Effect of glucan on natural killer (NK) cells: Further comparison between NK cell and bone marrow effector cell activities, J. Immunol. 123:607–612.

    Google Scholar 

  • Luini, W., Boraschi, D., Alberti, S., Aleotti, A., and Tagliabue, A., 1981, Morphological characterization of a cell population responsible for natural killer activity, Immunology 43:663–670.

    PubMed  CAS  Google Scholar 

  • Maluish, A. E., Ortaldo, J. R., and Herberman, R. B., 1982, Modulation of NK activity by recombinant leukocyte interferon in advanced cancer patients, in: NK Cells and Other Natural Effector Cells (R. B. Herberman, ed.), Academic Press, New York, pp. 1279–1283.

    Chapter  Google Scholar 

  • Metzger, Z., Hoffeld, J. T., and Oppenheim, J. J., 1980, Macrophage-mediated suppression. I. Evidence for participation of both hydrogen peroxide and prostaglandin in suppression of murine lymphocyte proliferation, J. Immunol. 124:983–988.

    CAS  Google Scholar 

  • Minato, M., Reid, L., and Bloom, B., 1981, On the heterogeneity of murine natural killer (NK) cells, J. Exp. Med. 154:750–762.

    Article  PubMed  CAS  Google Scholar 

  • Nair, M. P. N., Schwartz, S. A., Fernandes, G., Pahwa, R., Ikehara, S., and Good, R. A., 1981, Suppression of natural killer (NK) cell activity of spleen cells by thymocytes, Cell. Immunol. 58:9–18.

    Article  PubMed  CAS  Google Scholar 

  • Nathan, C. F., Bruckner, L. H., Silverstein, S. C., and Cohn, Z. A., 1979, Extracellular cytolysis by activated macrophages and granulocytes. I. Pharmacologic triggering of effector cells and the release of hydrogen peroxide, J. Exp. Med. 149:84–99.

    Article  PubMed  CAS  Google Scholar 

  • Nunn, M. E., Djeu, J. Y., Glaser, M., Lavrin, D. H., and Herberman, R. B., 1976, Natural cytotoxic reactivity of rat lymphocytes against syngeneic gross virus-induced lymphoma, J. Natl. Cancer Inst. 56:393–399.

    PubMed  CAS  Google Scholar 

  • Oehler, J. R., Lindsay, L. R., Nunn, M. E., and Herberman, R. B., 1978a, Natural cell-mediated cytotoxicity in rats. I. Tissue and strain distribution, and demonstration of a membrane receptor for the Fc portion of IgG, Int. J. Cancer 21:204–209.

    Article  PubMed  CAS  Google Scholar 

  • Oehler, J. R., Lindsay, L. R., Nunn, M. E., Holden, H. T., and Herberman, R. B., 1978b, Natural cell-mediated cytotoxicity in rats. II. In vivo augmentation of NK-cell activity, Int. J. Cancer 21:210–220.

    Article  PubMed  CAS  Google Scholar 

  • Ojo, E., and Wigzell, H., 1978, Natural killer cells may be the only cells in normal mouse lymphoid populations endorsed with cytolytic ability for antibody-coated tumor target cell, Scand. J. Immunol. 7:297–306.

    Article  PubMed  CAS  Google Scholar 

  • Ortaldo, J. R., Mantovani, A., Hobbs, D., Rubinstein, M., Pestka, S., and Herberman, R. B., 1983, Effects of several species of human leukocyte interferon on cytotoxic activity of NK cells and monocytes, Int. J. Cancer 31:285–289.

    Article  PubMed  CAS  Google Scholar 

  • Ortaldo, J. R., Timonen, T. T., and Herberman, R. B., 1984, Inhibition of activity of human NK cells by simple sugars: Discrimination between binding and post-binding events, Clin. Immunol. Immunopathol. (in press).

    Google Scholar 

  • Pandolfi, F., Strong, D. M., Slease, R. B., Smith, M. L., Ortaldo, J. R., and Herberman, R. B., 1980, Characterization of a suppressor T-cell chronic lymphocytic leukemia with ADCC but not NK activity, Blood 56:653–660.

    PubMed  CAS  Google Scholar 

  • Peter, H. H., Pauie-Fischer, J., Fridman, W. H., Aubert, C., Cesarini, J., Roubin, R., and Kourilsky, F. M., 1975, Cell-mediated cytotoxicity in vitro of human lymphocytes against a tissue culture melanoma cell line (IGR3), J. Immunol. 115:539–548.

    PubMed  CAS  Google Scholar 

  • Pollack, S. B., and Emmons, S. L., 1981, Cell—cell interactions suppress ADCC to tumor targets, in: Mediation of Cellular Immunity in Cancer by Immune Modifiers (M. A. Chirigos, M. Mitchell, M. J. Mastrangelo, and M. Krim, eds.), Raven Press, New York, pp. 225–235.

    Google Scholar 

  • Pross, H. F., and Jondal, M., 1975, Cytotoxic lymphocytes from normal donors. A functional marker of human non-T lymphocytes, Clin. Exp. Immunol. 21:226–235.

    PubMed  CAS  Google Scholar 

  • Renoux, C., Bardos, P., and Degenne, D., 1982, Sodium diethylthiocarbamate (DTC)-induced modifications of NK activity in the mouse, in: NK Cells and Other Natural Effector Cells (R. B. Herberman, ed.), Academic Press, New York, pp. 443–448.

    Chapter  Google Scholar 

  • Reynolds, C. W., and Herberman, R. B., 1981, In vitro augmentation of rat natural killer (NK) cell activity, J. Immunol. 126:1581–1585.

    PubMed  CAS  Google Scholar 

  • Reynolds, C. W., Timonen, T., and Herberman, R. B., 1981, Natural killer (NK) cell activity in the rat. I. Isolation and characterization of the effector cells, J. Immunol. 127:282–287.

    PubMed  CAS  Google Scholar 

  • Reynolds, C. W., Rees, R., Timonen, T., and Herberman, R. B., 1982a, Identification and characterization of the natural killer (NK) cells in rats, in: NK Cells and Other Natural Effector Cells (R. B. Herberman, ed.), Academic Press, New York, pp. 17–23.

    Chapter  Google Scholar 

  • Reynolds, C. W., Timonen, T. T., Holden, H. T., Hansen, C. T., and Herberman, R. B., 1982b, Natural killer (NK) cell activity in the rat. Analysis of effector cell morphology and effects of interferon on NK cell function in the athymic (nude) rat, Eur. J. Immunol. 12:577–582.

    Article  PubMed  CAS  Google Scholar 

  • Riccardi, C., Santoni, A., Barlozzari, T., Cesarini, C., and Herberman, R. B., 1981, Suppression of natural killer (NK) activity by splenic adherent cells of low NK-reactive mice, Int. J. Cancer 28:811–818.

    Article  PubMed  CAS  Google Scholar 

  • Riccardi, C., Barlozzari, T., Santoni, A., Cesarini, C., and Herberman, R. B., 1982a, Regulation of in vivo reactivity of natural killer (NK) cells, in: NK Cells and Other Natural Effector Cells (R. B. Herberman, ed.), Academic Press, New York, pp. 549–556.

    Chapter  Google Scholar 

  • Riccardi, C., Vose, B. M., and Herberman, R. B., 1982b, Regulation by interferon and T cells of IL-2 dependent growth of NK progenitor cells: A limiting dilution analysis, in: NK Cells and Other Natural Effector Cells (R. B. Herberman, ed.), Academic Press, New York, pp. 909–915.

    Chapter  Google Scholar 

  • Riccardi, C., Vose, B. M, and Herberman, R. B., 1983, Modulation of IL-2 dependent growth of mouse NK cells by interferon and T-lymphocytes, J. Immunol. 130:228–232.

    PubMed  CAS  Google Scholar 

  • Rosenberg, E. B., Herberman, R. B., Levine, P. H., Halterman, R. H., McCoy, J. L., and Wunderlich, J. R., 1972, Lymphocyte cytotoxicity reactions to leukemia-associated antigens in identical twins, Int. J. Cancer 9:648–658.

    Article  PubMed  CAS  Google Scholar 

  • Santoli, D., Trinchieri, G., Zmijewski, C. M., and Koprowski, H., 1976, HLA-related control of spontaneous and antibody-dependent cell-mediated cytotoxic activity in humans, J. Immunol. 117:765–770.

    PubMed  CAS  Google Scholar 

  • Santoni, A., Herberman, R. B., and Holden, H. T., 1979, Correlation between natural and antibody-dependent cell-mediated cytotoxicity against tumor targets in the mouse. II. Characterization of the effector cells, J. Natl. Cancer Inst. 63:995–1003.

    PubMed  CAS  Google Scholar 

  • Santoni, A., Riccardi, C., Barlozzari, T., and Herberman, R. B., 1980a, Suppression of activity of mouse natural killer (NK) cells by activated macrophages from mice treated with pyran copolymer, Int. J. Cancer 26:837–843.

    Article  PubMed  CAS  Google Scholar 

  • Santoni, A., Riccardi, C., Sorci, V., and Herberman, R. B., 1980b, Effects of adriamycin on the activity of mouse natural killer cells, J. Immunol. 124:2329–2335.

    PubMed  CAS  Google Scholar 

  • Santoni, A., Riccardi, C., Barlozzari, T., and Herberman, R. B., 1982a, C. parvum-induced suppressor cells for mouse NK activity, in: NK Cells and Other Natural Effector Cells (R. B. Herberman, ed.), Academic Press, New York, pp. 519–526.

    Chapter  Google Scholar 

  • Santoni, A., Riccardi, C., Barlozzari, T., and Herberman, R. B., 1982b, Natural suppressor cells for murine NK activity, in: NK Cells and Other Natural Effector Cells (R. B. Herberman, ed.), Academic Press, New York, pp. 527–533.

    Chapter  Google Scholar 

  • Saxena, Q. B., Saxena, R. K., and Adler, W. H., 1982, Ethanol and natural killer activity, in: NK Cells and Other Natural Effector Cells (R. B. Herberman, ed.), Academic Press, New York, pp. 651–656.

    Chapter  Google Scholar 

  • Saxena, R. K., 1982, Augmentation of mouse natural killer cell activity by alloantibody: A reverse ADCC reaction, in: NK Cells and Other Natural Elector Cells (R. B. Herberman, ed.), Academic Press, New York, pp. 449–454.

    Chapter  Google Scholar 

  • Seaman, W. E., Gindhart, T. D., Blackman, M. A., Dalai, B., Talal, N., and Werb, Z., 1981, Natural killing of tumor cells by human peripheral blood cells. Suppression of killing in vitro by tumor-promoting phorbol diesters, J. Clin. Invest. 67:1324–1333.

    Article  PubMed  CAS  Google Scholar 

  • Seaman, W. E., Gindhart, T. D., Blackman, M. A., Dalai, B., Talal, N., and Werb, Z., 1982, Suppression of natural killing in vitro by monocytes and polymorphonuclear leukocytes, J. Clin. Invest. 69:876–888.

    Article  PubMed  CAS  Google Scholar 

  • Seeley, J. K., and Karre, K., 1980, MLC-induced cytotoxicity against NK-sensitive targets, in: Natural Cell-Mediated Immunity Against Tumors (R. B. Herberman, ed.), Academic Press, New York, pp. 477–497.

    Google Scholar 

  • Senik, A., and Kolb, J. P., 1982, Differences between phorbol esters and interferon induced activations of mouse NK cells, in: NK Cells and Other Natural Effector Cells (R. B. Herberman, ed.), Academic Press, New York, pp. 437–442.

    Chapter  Google Scholar 

  • Stringfellow, D. A., 1978, Prostaglandin restoration of the interferon response of hyporeactive animals, Science 201:376–378.

    Article  PubMed  CAS  Google Scholar 

  • Stutman, O., 1978, Natural cytotoxic cells against solid tumors in mice. II. Some characteristics of the effector cells, J. Immunol. 121:1827–1834.

    PubMed  Google Scholar 

  • Stutman, O., Figarella, E. F., Paige, C. J., and Lattime, E. C., 1980, Natural cytotoxic (NC) cells against solid tumors in mice: General characteristics and comparison to natural killer (NK) cells, in: Natural Cell-Mediated Immunity Against Tumors (R. B. Herberman, ed.), Academic Press, New York, pp. 187–229.

    Google Scholar 

  • Sulica, A., Gherman, M., Galatiuc, C., Manciulea, M., and Herberman, R. B., 1982, Inhibition of human natural killer cell activity by cytophilic immunoglobulin G, J. Immunol. 128:1031–1036.

    PubMed  CAS  Google Scholar 

  • Tarkkanen, J., and Saksela, E., 1982, Umbilical cord blood-derived suppressor cells of human natural killer cell activity are inhibited by interferon, Scand. J. Immunol. 15:149–157.

    Article  PubMed  CAS  Google Scholar 

  • Timonen, T., Saksela, E., Ranki, A., and Hayry, P., 1979, Fractionation, morphological and functional characterization of effector cells responsible for human natural killer activity against cell-line targets, Cell. Immunol. 48:133–148.

    Article  PubMed  CAS  Google Scholar 

  • Timonen, T., Ortaldo, J. R., and Herberman, R. B., 1981, Characteristics of human large granular lymphocytes and relationship to natural killer and K cells, J. Exp. Med. 153:569–582.

    Article  PubMed  CAS  Google Scholar 

  • Timonen, T., Ortaldo, J. R., and Herberman, R. B., 1982, Analysis by a single cell cytotoxicity assay of natural killer (NK) cell frequencies among human large granular lymphocytes and of the effects of interferon on their activity, J. Immunol. 128:2514–2521.

    PubMed  CAS  Google Scholar 

  • Trinchieri, G., and Santoli, D., 1978, Anti-viral activity induced by culturing lymphocytes with tumor-derived or virus-transformed cells. Enhancement of human natural killer cell activity by interferon and antagonistic inhibition of susceptibility of target cells to lysis, J. Exp. Med. 147:1314–1333.

    Article  PubMed  CAS  Google Scholar 

  • Uchida, A., and Micksche, M., 1982a, Suppression of NK cell activity by adherent cells from malignant pleural effusions of cancer patients, in: NK Cells and Other Natural Effector Cells (R. B. Herberman, ed.), Academic Press, New York, pp. 589–594.

    Chapter  Google Scholar 

  • Uchida, A., and Micksche, M., 1982b, Augmentation of NK cell activity in cancer patients by OK432: Activation of NK cells and induction of suppressor cells, in: NK Cells and Other Natural Effector Cells (R. B. Herberman, ed.), Academic Press, New York, pp. 1303–1308.

    Chapter  Google Scholar 

  • Vose, B. M., and Moore, M., 1979, Suppressor cell activity of lymphocytes infiltrating human lung and breast tumors, Int. J. Cancer 24:579–585.

    Article  PubMed  CAS  Google Scholar 

  • Vose, B. M., Riccardi, C., Marchmont, R. J., and Bonnard, G. D., 1982, Clonal analysis of human natural killer cells, in: NK Cells and Other Natural Effector Cells (R. B. Herberman, ed.), Academic Press, New York, pp. 879–885.

    Chapter  Google Scholar 

  • West, W. H., Cannon, G. B., Kay, H. D., Bonnard, G. D., and Herberman, R. B., 1977, Natural cytotoxic reactivity of human lymphocytes against a myeloid cell line: Characterization of effector cells, J. Immunol. 118:355–361.

    PubMed  CAS  Google Scholar 

  • Wolfe, S. A., Tracey, D. E., and Henney, C. S., 1976, Induction of “natural killer” cells by BCG, Nature 262:584–586.

    Article  PubMed  CAS  Google Scholar 

  • Zarling, J. M., Kung, P. C., and Bach, F. H., 1982, In vitro stimulation of lymphocytes with allogeneic normal cells and autologous EB virus transformed lymphoblastoid cell lines: Distinction between NK-like cells and cytotoxic T lymphocytes by monoclonal antibodies, in: NK Cells and Other Natural Effector Cells (R. B. Herberman, ed.), Academic Press, New York, pp. 791–797.

    Chapter  Google Scholar 

Download references

Author information

Author notes

  1. Angela Santoni

    Present address: III Cattedra, Istituto di Patologia Generale, 00161, Rome, Italy

Authors and Affiliations

  1. Biological Therapeutics Branch, Biological Response Modifiers Program, Division of Cancer Treatment, National Cancer Institute, Frederick, Maryland, 21701, USA

    Ronald B. Herberman & Angela Santoni

Authors
  1. Ronald B. Herberman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Angela Santoni
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Grace Cancer Drug Center, Roswell Park Memorial Institute, Buffalo, New York, USA

    Enrico Mihich

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Plenum Press, New York

About this chapter

Cite this chapter

Herberman, R.B., Santoni, A. (1984). Regulation of Natural Killer Cell Activity. In: Mihich, E. (eds) Biological Responses in Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4682-1_5

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-4682-1_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4684-5

  • Online ISBN: 978-1-4684-4682-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation