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Proliferation and Differentiation Control Mechanisms in Myeloid Leukemia

  • Chapter
Biological Responses in Cancer

Abstract

Studies of myeloid leukemic cell lines and primary cultures of leukemic bone marrow have yielded information on humoral regulation of growth and differentiation of myeloid cells and have revealed specific abnormalities in regulatory control that would appear to play important roles in the development and progression of hematopoietic neoplasia. Already considerable in vitro data have been accumulated to document the feasibility of the clinical application of such biological response modifiers as retinoic acid, interferon, tumor necrosis factor, prostaglandin E, and differentiation-inducing proteins in a strategy designed to revert malignant hematopoietic cells to a pattern of normal proliferation and differentiation, or to mediate their selective ablation.

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  1. Department of Developmental Hematopoiesis, Sloan-Kettering Institute for Cancer Research, New York, New York, 10021, USA

    Malcolm A. S. Moore

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  1. Malcolm A. S. Moore
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  1. Grace Cancer Drug Center, Roswell Park Memorial Institute, Buffalo, New York, USA

    Enrico Mihich

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© 1984 Plenum Press, New York

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Moore, M.A.S. (1984). Proliferation and Differentiation Control Mechanisms in Myeloid Leukemia. In: Mihich, E. (eds) Biological Responses in Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4682-1_4

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  • DOI: https://doi.org/10.1007/978-1-4684-4682-1_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4684-5

  • Online ISBN: 978-1-4684-4682-1

  • eBook Packages: Springer Book Archive

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