Abstract
Cerebral edema resulting from cerebral ischemia continues to be one of the most frustrating and least understood problems of contemporary medicine. Not only is ischemia an important primary phenomenon, it is becoming increasingly recognized as an important secondary phenomenon in many forms of brain insult. Pharmacological agents utilized clinically to treat the condition have varying degrees of efficacy and in general represent only partial solutions to the problem. Numerous clinical and experimental investigations have been done in an attempt to pinpoint the mechanisms leading to edema but none has provided a definite cause-effect sequence. Although biochemical mechanisms have received much attention, we feel that inorganic ion homeostasis appears to be one of the essentials in preventing cerebral edema following ischemia. One of the essentials in unraveling the pathophysiology of ionic disturbances is a precise understanding of electrolyte distribution in the cells and regions of the brain before and after the onset of ischemia as well as after restitution of blood flow.
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References
Chandler JA: Principles of x-ray microanalysis in biology, Scanning Microscopy II, AMF O’Hare, Illinois, 595–606 (1979).
Chang JJ, Walter CA, Dubocket J: The observation of frozen hydrated sections by CTEM and STEM, Proc Electron Micros Soc Amer, Bailey GW, (Ed) Claitors Pub Div, Baton Rouge, LA, 642–643 (1981).
Coleman SE, Duggan J, Hackett RL: Changes in freeze-fractured nuclei after renal ischemia and reflow in the rat. Exptl Mol Pathol 23: 59–69 (1975).
Dorge A, Rick R, Gehring K, Mason J, Thomas K: Preparation and applicability of freeze-dried sections in the microprobe analysis of biological soft tissue. J. Microscopie Biol Cell 22: 205–214 (1975).
Eccles JC: In: The Physiology of Nerve Cells, Johns Hopkins Press Baltimore, (1957).
Gupta BL, Hall TL: Ions and water in cells and tissues studied by microprobe analysis of frozen hydrated sections in the SEM: Proc Electron Micros Soc Amer; Bailey GW, (Ed): Claitors Pub Div, Baton Rouge, La, 654–657 (1980).
Hossman KA, Kleihues P: Reversibility of ischemic brain damage. Arch Neurol 29: 375–384 (1973).
Hren JJ, Goldstein J, Joy DC: Introduction to analytical electron microscopy Plenum Press, New York, (1979).
Hutchinson TE: Determination of subcellular elemental concentration through ultrahigh resolution electron microprobe analysis. International Rev Cytol 58: 115–158 (1979).
Ignelzi RJ: Cerebral edema: Present perspectives. Neuro-surgery 4: 338–342 (1979a).
Ignelzi RJ: Pathophysiology of the nucleus in brain edema. In: Brain Edema, Cervos-Navarro J, Ferszt R (Eds), Raven Press, New York, Adv Neurol 28: 281–289 (1980b).
Ignelzi RJ: Sodium potassium and metabolic studies of glial, liver and kidney nuclei under anoxie ischemic conditions. Neurological Research 2: 35–46 (1980c).
Ignelzi RJ: Cerebral edema. The status of the science — the state of the art. Progress of Neurological Surgery (1980d).
Ignelzi RJ, Wickham MG: Light element abdundance in brain nuclei using energy dispersive x-ray analysis and atomic absorption spectrophotometry. Neurological Res 1: 341–348 (1980).
Isaacson M, Ohtsuki M, Utlaut M: Electron microscopy of individual atoms. In: Introduction to Analytical Electron Microscopy. Hren J, Goldstein J, Joy DC (Eds) Plenum Press, New York, 343–368 (1979).
Joy DC: Progress in the quantitation of electron energy-loss spectra, Scanning Electron Microscopy II. SEM, Inc., AMF O’Hare, Illinois, 817–826 (1978).
Katzman R: Electrolyte distribution in the mammalian central nervous system. Are glia high sodium cells? Neurology Minneap 11: 27–36 (1961).
Kirsch WM, Ignelzi RJ: Cerebral Edema: The role of astroglia. In: Current Controversies in Neurosurgery, T Morley (Ed), W.B. Saunders, Philadelphia, 595–604 (1976).
Koch A, Ranch JB Jr, Newman B: Ionic content of the neuro-glia, Exp. Neurol 6: 186–200 (1962).
Korenbrut JI: Ion transport in membranes: Incorporation of biological ion-translocating proteins in model membrane systems. Ann Rev Physiol 39: 19–49 (1977).
Lechene CP: Electron probe microanalysis: its present, its future. Am J Physiol 232: 391–396 (1977).
Lifshin E, Ciccarelli MF: Present trends in x-ray analysis with the SEM. In: Scanning Electron Microscopy I, Johari O, Corvin I, (Eds.) Chicago: IITRI, 89–96 (1973).
Litvan GG: Mechanism of cryoinjury in biological systems. Cryobiol. 9: 182–191 (1977).
Marshall AT: Electron probe x-ray microanalysis. In: Principles and Techniques of Scanning Electron Microscopy, Hayat MA (Ed), Van Nostrand Reinhold Co., New York, 4: 103–173 (1975).
Masters SK, Bell SW, Ingram P, Adams DO, Shelburne JD: Preparative techniques for freezing and freeze-sectioning macrophages for energy dispersive x-ray microanalysis. Scanning Electron Microscopy III, SEM Inc., AMF O’Hare, Illinois, 97–110 (1979).
Mehard CW, Akers GD, Breeze R, Ignelzi RJ: Element Fluxes in Ischemic Mouse Brain Nuclei In: 39th Ann Proc Electron Microscopy Soc Amer., Bailey GW, (Ed) Atlanta, GA, 652–53 (1981).
Mehard CW, Ignelzi RJ: Cryoultramicrotomy in Biology and Brain tissue in Analytical Electron Microscopy, Geiss RH, (Ed) San Francisco Press, Inc. San Francisco, CA, 257–264 (1981).
Rich R, Dorge A, Von Armin E, Thurau K: Electron microprobe analysis of frog skin epithelium: Evidence for a syncytial sodium transport compartment J Membrane Biol 39: 313–331 (1978).
Robards AW: Utrastructural methods for looking at frozen cells. Sci Prog Oxf 61: 1–40 (1974).
Russ JC: Resolution and sensitivity of x-ray microanalysis in biological sections by scanning and conventional transmission electron microscopy. In: Scanning Electron Microscopy I, Johari O, Corvin I (Eds) Chicago: IITRI, 73–80 (1972).
Shuman H, Somlyo AV, Somlyo AP: Quantitative electron probe microanalysis of biological thin sections: methods and validity. Utramicros 1: 317–339 (1976).
Siebert G, Humphrey GB: Enzymology of the nucleus. In: Advances in Enzymology, Nord FF (Ed) Interscience New York, 27: 239–288 (1965).
Thurau K, Dorge RR, Roloff CH, Beck F, Mason R, Bauer R: Intracellular electrolyte concentrations in epithelial tissue during various functional states. Scanning Electron Micros II, SEM Inc., AMF O’Hare, Illinois (1979).
Trump BF, Arstila AU: Cell injury and cell death. In: Principle of Pathobiology, LaVia MF, Hull RB (Eds) Oxford Univ Press New York: 8995 (1971).
Woodward DL, Reed DJ, Woodbury DM: Extracellular space of rat cerebral cortex. Am J Physiol 212: 367–370 (1967).
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© 1984 Plenum Press, New York
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Ignelzi, R.J., Mehard, C.W., Srull, A. (1984). Element Fluxes in Ischemic Brain Nuclei and Their Possible Relationship to Brain Edema as Studied by Energy Dispersive X-Ray Analysis. In: Go, K.G., Baethmann, A. (eds) Recent Progress in the Study and Therapy of Brain Edema. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4616-6_54
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DOI: https://doi.org/10.1007/978-1-4684-4616-6_54
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