Abstract
The small-animal model of focal cerebral ischemia produced by occluding a middle cerebral (MCA) of the rat has already proved useful in the studies of pathophysiology of this type of cerebro-vascular disease12,13. Even though there are several other models of cerebral ischemia in small animals, such as mongolian gerbils or rats, occlusion of the middle cerebral artery has the advantage of producing focal incomplete ischemia, such as is most commonly encountered in human stroke. Because of the reproducibility of the MCA occlusion model (in respect of the distribution of irreversible ischemic cell changes and the topography and magnitude of alterations in local cerebral blood flow) this experimental approach is particularly suited for investigations with the range of autoradio-graphic techniques, now available to assess blood-brain barrier (BBB) permeability and local cerebral blood flow (CBF).
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© 1984 Plenum Press, New York
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Shigeno, T., Teasdale, G.M., McCulloch, J., Mandelow, D., Graham, D.I. (1984). Brain Edema Following Focal Cerebral Ischemia in the Rat. In: Go, K.G., Baethmann, A. (eds) Recent Progress in the Study and Therapy of Brain Edema. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4616-6_44
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DOI: https://doi.org/10.1007/978-1-4684-4616-6_44
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