Abstract
Analysis of the state of tissue water in brain parenchyma is essential for studying the pathogenesis of brain edema. However, due to technological problems the state of water in tissue remains difficult to assess. Ambo1 attempted in 1951 to measure bound water by the cobalt chloride method applied to formalin-fixed brain. Utilizing NMR, Go and Edzes5 studied in 1975 the state of protons of fresh brain tissue and found an increase in relaxation time of edematous brain tissue compared to controls. An increase of relaxation time is considered to result from an increase of free water. However, absolute values of free and bound water have not been determined yet.
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References
Ambo H: Experimental swelling of the brain and its bound water, Acta Pathol Japon 1, 63–71 (1951).
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© 1984 Plenum Press, New York
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Furuse, M., Gonda, T., Kuchiwaki, H., Hirai, N., Inao, S., Kageyama, N. (1984). Thermal Analysis on the State of Free and Bound Water in Normal and Edematous Brains. In: Go, K.G., Baethmann, A. (eds) Recent Progress in the Study and Therapy of Brain Edema. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4616-6_28
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DOI: https://doi.org/10.1007/978-1-4684-4616-6_28
Publisher Name: Springer, Boston, MA
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