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Endogenous Pools of Arachidonic Acid-Enriched Membrane Lipids in Cryogenic Brain Edema

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Recent Progress in the Study and Therapy of Brain Edema

Abstract

The understanding of neurochemical changes associated with the evolution of brain edema is a prerequisite to the development of newer and more effective treatments of this condition. During brain edema, phospholipids and their long-chain highly unsaturated acyl groups, especially arachidonic and docosahexaenoic acids, have been postulated to be the earliest membrane components altered17. This is based on the finding that there is an increase in free fatty acid pool size at the onset of ischemia7,10,13,15,21,30,36,37,39,44, carotid artery ligation , and hypoxia . This lipid effect has been seen in several animals, including primates’. Arachidonic, stearic, docosahexaenoic, palmitic, and oleic acids are produced rapidly at the onset of ischemia”. Using head-focus microwave irradiation, it has been shown that rapid brain fixation reduces the free fatty acid pool size to trace levels and that accumulation of these free fatty acids already can be measured during the first few seconds of oxygen deprivation21.

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Author information

Authors and Affiliations

  1. LSU Eye Center, Louisiana State University Medical Center, School of Medicine, 136 S. Roman St., New Orleans, LA, 70112, USA

    Dr. Nicolas G. Bazan

  2. Instituto de Investigaciones Bioquimicas, Universidad Nacional de Sur-Consejo Nacional de Investigaciones Cientificas y Tecnicas, Bahia Bianca, Argentina

    Enrique Politi & Elena B. de Rodriguez Turco

Authors
  1. Dr. Nicolas G. Bazan
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  2. Enrique Politi
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  3. Elena B. de Rodriguez Turco
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Editor information

Editors and Affiliations

  1. University of Groningen, Groningen, The Netherlands

    K. G. Go

  2. Institute of Surgical Research Grosshadern Clinic H, University of Munich, Munich, Federal Republic of Germany

    A. Baethmann

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© 1984 Plenum Press, New York

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Bazan, N.G., Politi, E., de Rodriguez Turco, E.B. (1984). Endogenous Pools of Arachidonic Acid-Enriched Membrane Lipids in Cryogenic Brain Edema. In: Go, K.G., Baethmann, A. (eds) Recent Progress in the Study and Therapy of Brain Edema. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4616-6_19

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  • DOI: https://doi.org/10.1007/978-1-4684-4616-6_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4618-0

  • Online ISBN: 978-1-4684-4616-6

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