Abstract
Traumatic or ischemic injury to the brain causes focal tissue necrosis together with an opening of the blood-brain barrier leading to an influx of vasogenic edema into the cerebral parenchyma. Clinical and experimental observations suggest an involvement of chemical factors, or compounds mediating secondary brain damage, such as vasogenic brain edema. Mediators may enhance the primary damage inflicted to the blood brain barrier, induce derangements of the cerebral microcirculation, and cause formation of secondary cytotoxic necrosis, or cell swelling in focal and perifocal areas. Many systems and compounds have been studied in this context2. A great number of reports, including those of ourselves demonstrate glutamate and free fatty acids to exhibit powerful neurotoxic properties. These findings together with the occurrence of glutamate and free fatty acids either in the intra-cellular compartment, or the lipid moiety in vast amounts in normal brain render both substances excellent candidates as mediators of secondary brain damage. Exposure of brain tissue to glutamate by iontophoretic administration to cerebral cortex, or by ventriculo-cisternal perfusion in-vivo was found to induce swelling and destruction of cellular elements, or gross brain edema, respective-ly14,l,9,13.
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References
Baethmann A, Oettinger W, Rothenfuszer W, Geiger R: Biochemical aspects of cerebral edema. In: Pathophysiology of Cerebral Energy Metabolism, Mrsulja BB, Rakic L, Klatzo I, Spatz M (Eds): Plenum Press New York 189–209 (1979).
Baethmann A, Oettinger W, Rothenfuszer W, Kempski O, Unterberg A, Geiger R: Brain edema factors: Current state with particular reference to plasma constituents and glutamate. In: Brain edema, Pathology, Diagnosis and Therapy”, Cervos-Navarro J, Ferszt R (Eds): Adv Neurol 28. Raven Press New York 171–195 (1980).
Bazan NS, Rodriguez de Turco EB: Membrane lipids in the patho-genesis of brain edema: Phospholipids and arachidonic acids, the earliest membrane components changes at the onset of ischemia. In: Brain Edema, Pathology, Diagnosis and Therapy. Cervos-Navarro J, Ferszt R (Eds): Adv Neurol 28. Raven Press New York 179–205 (1980).
Chan PH, Fishman RA: Brain edema: Induction in cortical slices by polyunsaturated fatty acids. Science 201: 358–360 (1978).
Gazendam J, Go KG, Van Zanten AK: Composition of isolated edema fluid in cold-induced brain edema. J Neurosurg 51: 70–77 (1979).
Go KG, Patberg WR, Teelken AW, Gazendam J: The starling hypothesis of capillary fluid exchange in relation to brain edema. In: Dynamics of Brain Edema. Pappius HM, Feindel W (Eds): Springer Berlin-Heidelberg-New York 63–67 (1976).
Harvey JA, McIlwain H: Excitatory acidic aminoacids and the cation content and sodium ionflux of isolated tissues from the brain. Biochem J 108: 269–276 (1968).
Henn FA, Goldstein MN Hamberger A: Uptake of the neurotransmitter candidate glutamate by glia Nature 249: 663–664 (1974).
Kempski O, Baethmann A: Localization of cerebral edema induced by glutamate by measurement of tissue impedance. Proc Internat Conf Electr Bio-Impedance, 113–116 Tokyo (1981).
Kontos HA, Wei EP, Povlishock JT, Dietrich WD, Magiera CJ, Ellis EF: Cerebral arteriolar damage by arachidonic acid and prostaglandin G2. Science 109: 1242–1245 (1980).
Lowry OH, Passonneau JV: A Flexible System of Enzymatic Analysis Academic press New York 184 (1972).
Reulen HJ, Graham R, Spatz M, Klatzo I: Role of pressure gradients and bulk flow in dynamics of vasogenic brain edema. J Neurosurgery 46: 24–35 (1977).
Rothenfuszer W: Die Bedeutung von Glutamat als Hirnödemfaktor. Thesis, München (1982).
Van Harreveld A, Fifkova E: Light-and electronmicroscopic changes in central nervous tissue after electrophoretic injection of glutamate. Experiment Molec Pathology 15: 61–81 (1971).
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© 1984 Plenum Press, New York
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Hauff, K.M. et al. (1984). Glutamate and Free Fatty Acid Concentrations in Extracellular Vasogenic Edema Fluid. In: Go, K.G., Baethmann, A. (eds) Recent Progress in the Study and Therapy of Brain Edema. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4616-6_17
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DOI: https://doi.org/10.1007/978-1-4684-4616-6_17
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