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The Aging Cell Surface

Structural and Biochemical Alterations Associated with Progressive Subcultivation of Human Diploid Fibroblasts

  • Chapter
Aging and Cell Structure

Abstract

The cell membrane is a complex fluid mosaic of lipid and protein (Bretscher, 1973; Singer and Nicolson, 1972; Steck, 1974; Shinitzky and Henkart, 1979) between the cellular interior and the immediate extracellular environment. It provides the foundation for the structural and molecular mechanisms that govern cell-to-cell interaction, external signal reception, cell adhesion and motility, and establishment and maintenance of cell shape. Signal reception and intercellular communication play important roles in the control of cell cycle kinetics and proliferation (Clarkson and Baserga, 1974). Proteins which effect cell shape and motility also participate in mitotic events and the interphase stages of G1, S, and G2 (Baserga, 1968), in addition to establishing and maintaining contact with other cells and/or their normal or artificial substrates (Adelstein et al., 1979; Weihing, 1979).

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Authors and Affiliations

  1. Department of Anatomy, The University of New Mexico School of Medicine, Albuquerque, New Mexico, 87131, USA

    Robert O. Kelley

  2. Department of Biology, The University of New Mexico College of Arts and Sciences, Albuquerque, New Mexico, 87131, USA

    Kathryn G. Vogel

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  1. Robert O. Kelley
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Editors and Affiliations

  1. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    John E. Johnson Jr.

  2. National Institute on Aging, NIH Baltimore City Hospital, Baltimore, Maryland, USA

    John E. Johnson Jr.

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Kelley, R.O., Vogel, K.G. (1984). The Aging Cell Surface. In: Johnson, J.E. (eds) Aging and Cell Structure. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4607-4_1

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  • DOI: https://doi.org/10.1007/978-1-4684-4607-4_1

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