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Intestinal Phosphate Transport

  • Chapter
The Enzymes of Biological Membranes

Abstract

Functions of inorganic phosphate (Pi) differ widely in the vertebrate organism. This can be illustrated, e.g., by the role of phosphate in soft tissue on the one hand, where it serves mainly as an inorganic precursor of a large variety of essential organic phosphocompounds (phospholipids, nucleotides, metabolic intermediates, phosphoproteins, etc.), and by its occurrence in the skeletal system on the other hand, where it exists in crystalline form as hydroxyapatite together with calcium. Pi in mineralized bone, makes up as much as 85% of total body phosphate. The remaining 15% is accounted for by soft-tissue Pi and is about equally distributed between muscle and other nonosseous tissue (Bringhurst and Potts, 1979).

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References

  • Avioli, L. V.. and Birge. S. J., 1977, Controversies regarding intestinal phosphate transport and absorption,in: Phosphate Metabolism S. G. Massry and E. Ritz, Plenum Press. New York. pp. 507— 513.

    Google Scholar 

  • Avioli. R. C., Miller. R. A., and Birge, S. J., 1981,Characterization of phosphate uptake in isolated chick intestinal cells, Min.Electrolyte Metabol. 5:287–295.

    CAS  Google Scholar 

  • Bachelet. M. Lacour. B.and Ulmann, A., 1982, Early effects of la,25-dihydroxy-vitamin D3 on phosphate absorption. A role for alkaline phosphataseMin. Electrolyte Metabol. 8: 261–266.

    CAS  Google Scholar 

  • Ben-Ghadalia, D.. Tagari. H., Zamwel, S., and Bondi, A., 1975, Solubility and net exchange of calcium,magnesium and phosphorus in digesta flowing along the gut of the sheep. Brit. J. Nutr. 33: 87–94.

    Google Scholar 

  • Berner, W.Kinne, R., and Murer, H., 1976, Phosphate transport into brush-border membrane vesicles isolated from rat small intestine. Biochem. J. 160: 467–474.

    PubMed  CAS  Google Scholar 

  • Birge, S. J., and Avioli. R. C., 1981, Intestinal phosphate transport and alkaline phosphatase activity in the chick, Am. J. Physiol. 240: E384 — E390.

    PubMed  CAS  Google Scholar 

  • Birge, S. J., and Miller, R., 1977, Role of phosphate in the action of vitamin D on the intestine, J. Clin. Invest. 60: 980–988.

    PubMed  CAS  Google Scholar 

  • Blahos, J., and Care, A. D., 1981, The jejunum is the site of maximal rate of intestinal absorption of phosphate in chicks. Physiol. Bohemoslov. 30: 157–159.

    PubMed  CAS  Google Scholar 

  • Bringhurst, F. R., and Potts, J. T., 1979, Calcium and phosphate distribution, turnover, and metabolic actions, in: Endocrinology, Vol. 2 (L. J. DeGroot, G. F. Cahill, Jr., L. Martini, D. H. Nelson, W. D. Odell, J. T. Potts, Jr., E. Steinberger, and A. I. Winegrad, eds.), Grune & Stratton, New York, pp. 551–592.

    Google Scholar 

  • Bronner, F., 1976, Vitamin D deficiency and rickets, Am. J. Clin. Nutr. 29: 1307–1314.

    PubMed  CAS  Google Scholar 

  • Bronner, F., and Peterlik, M. (eds), 1981, Calcium and Phosphate Transport Across Biomembranes, Academic Press, New York.

    Google Scholar 

  • Chen, T. C., Castillo, L., Korycka-Dahl, M., and DeLuca, H. F., 1974, Role of vitamin D metabolites in phosphate transport of rat intestine, J. Nutr. 104: 1056–1060.

    PubMed  CAS  Google Scholar 

  • Cheng, H., and Leblond, C. P., 1974, Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine, Am. J. Anat. 141: 461–562.

    PubMed  CAS  Google Scholar 

  • Coburn, J. W., Brickman, A. S., Hartenbower, D. L., and Norman, A. W., 1977, Intestinal phosphate absorption in normal and uremic man: Effects of 1,25(OH)2-vitamin D3 and la(OH)-vitamin D3. in: Phosphate Metabolism ( S. G. Massry and E. Ritz, eds.), Plenum Press, New York, pp. 549–557.

    Google Scholar 

  • Corman, B., Touvay, C., Poujeol, P., and deRouffignac, C., 1978, Glucose-mediated inhibition of phosphate reabsorption in rat kidney, Am. J. Physiol. 235: F430 — F439.

    PubMed  CAS  Google Scholar 

  • Corradino, R. A., 1973a, Embryonic chick intestine in organ culture: A unique system for the study of the intestinal calcium absorptive mechanism, J. Cell. Biol. 58: 64–78.

    PubMed  CAS  Google Scholar 

  • Corradino, R. A., 1973b, Embryonic chick intestine in organ culture: Response to vitamin D3 and its metabolites, Science 179: 402–405.

    PubMed  CAS  Google Scholar 

  • Corradino, R. A., 1974, Embryonic chick intestine in organ culture: Interaction of adenylate cyclase and vitamin D3-mediated calcium absorptive mechanism, Endocrinology 94: 1607–1614.

    PubMed  CAS  Google Scholar 

  • Corradino, R. A., 1979a, Embryonic chick intestine in organ culture: Hydrocortisone and vitamin D-mediated processes, Arch. Biochem. Biophys. 192: 302–310.

    PubMed  CAS  Google Scholar 

  • Corradino, R. A., 1979b, Hydrocortisone and vitamin D3 stimulation of 3213,-phosphate accumulation by organ-cultured chick embryo duodenum, Horm. Metabol. Res. 11: 519–523.

    CAS  Google Scholar 

  • Cremaschi, D., James, P. S., Meyer, G., Peacock, M. A., and Smith, M. W., 1982, Membrane potentials of differentiating enterocytes, Biochim. Biophys. Acta 688: 271–274.

    PubMed  CAS  Google Scholar 

  • Cross, H. S., and Peterlik, M., 1980, Role of differentiation and hormonal effectors (vitamin D3, insulin, cyclic nucleotides) in phosphate transport by embryonic intestine, Hoppe Seyler’s Z. Physiol. Chem. 361: 1275.

    Google Scholar 

  • Cross, H. S., and Peterlik, M., 1981, Effects of vitamin D and insulin on phosphate transport in the differentiating chick small intestine, in: Calcium and Phosphate Transport Across Biomembranes ( F. Bronner and M. Peterlik, eds.), Academic Press, New York,,pp. 293–296.

    Google Scholar 

  • Cross, H. S., and Peterlik, M., 1982a, Hormonal regulation of phosphate transport in the differentiating chick small intestine, in: Regulation of Phosphate and Mineral Metabolism ( S. G. Massry, J. M. Letteri, and E. Ritz, eds.), Plenum Press, New York, pp. 127–135.

    Google Scholar 

  • Cross, H. S., and Peterlik, M., 1982b, Differential response of enterocytes to vitamin D during embryonic development: Induction of intestinal inorganic phosphate, D-glucose and calcium uptake, Horm. Metabol. Res. 14: 649–652.

    CAS  Google Scholar 

  • Cross, H. S., and Peterlik, M., 1983, Vitamin D stimulates (Na+-K+)ATPase activity in chick small intestine, FEBS Lett. 153: 141–145.

    PubMed  CAS  Google Scholar 

  • Danisi, G., and Straub, R. W., 1980, Unidirectional influx of phosphate across the mucosal membrane of rabbit small intestine, Pfluegers Arch. 385: 117–122.

    CAS  Google Scholar 

  • Danisi, G., Bonjour, J.-Ph., and Straub, R. W., 1980, Regulation of Na-dependent phosphate influx across the mucosal border of duodenum by 1,25-dihydroxycholecalciferol, Pfluegers Arch. 388: 227–232.

    CAS  Google Scholar 

  • Danisi, G., Murer, H., and Straub, R. W., 1982, Effect of pH on rabbit intestinal phosphate transport,Experientia 38: 712.

    Google Scholar 

  • DeFronzo, R. A., Goldberg, M., and Agus, Y., 1976, The effects of glucose and insulin on renal electrolyte transport, J. Clin. Invest. 58: 83–90.

    PubMed  CAS  Google Scholar 

  • Demand, H. A., Weichmann, K., and Berg, G., 1968, Some effects of epinephrine on histamine-induced human gastric secretion, Gastroenterology 55: 272–276.

    PubMed  CAS  Google Scholar 

  • Farrington, K., Epstein, O., Varghese, Z., Newman, S. P., Moorhead, J. F., and Sherlock, S., 1979, Effect of oral 1,25-dihydroxycholecalciferol on calcium and phosphate malabsorption in primary biliary cirrhosis, Gut 20: 616–619.

    PubMed  CAS  Google Scholar 

  • Ferraro, C., Ladizesky, M., Cabrejas, M., Montoreano, R., and Mautalen, C., 1976, Intestinal absorption of phosphate: Action of protein synthesis inhibitors and glucocorticoids in the rat, J. Nutr. 106: 1752–1756.

    PubMed  CAS  Google Scholar 

  • Fontaine, O., Matsumoto, T., Goodman, D. B. P., and Rasmussen, H., 1981, Liponomic control of Ca’ transport: Relationship to mechanism of action of 1,25-dihydroxyvitamin D3, Proc. Natl. Acad. Sci. USA 78: 1751–1754.

    PubMed  CAS  Google Scholar 

  • Fox, J., Bunnett, N. W., Farrar, A. R., and Care, A. D., 1981, Stimulation by low phosphorus and low calcium diets of duodenal absorption of phosphate in betamethasone-treated chicks, J. Endocrinol. 88: 147–153.

    PubMed  CAS  Google Scholar 

  • Fraser, D. R., 1980, Regulation of the metabolism of vitamin D, Physiol. Rev. 60: 551–613.

    PubMed  CAS  Google Scholar 

  • Fraser, D. R., and Kodicek, E., 1970, Unique biosynthesis by kidney of a biologically active vitamin D metabolite, Nature 228: 764–766.

    PubMed  CAS  Google Scholar 

  • Fuchs, R., and Peterlik, M., 1979a, Vitamin D-induced transepithelial phosphate and calcium transport by chick jejunum: Effect of microfilamentous and microtubular inhibitors, FEBS Lett. 100: 357–359.

    PubMed  CAS  Google Scholar 

  • Fuchs, R., and Peterlik, M., 1979b, Pathways of phosphate transport in chick jejunum: Influence of vitamin D and extracellular sodium, Pfluegers Arch. 381: 217–222.

    CAS  Google Scholar 

  • Fuchs, R., and Peterlik, M., 1983, Effect of vitamin D on transmucosal sodium fluxes, Calc. Tissue Int. 35 (Suppl.): A50.

    Google Scholar 

  • Fuchs, R., Cross, H. S., and Peterlik, M., 1982, Effect of vitamin D on intestinal sodium and sodium-dependent transport, in: Vitamin D: Chemical, Biochemical and Clinical Endocrinology of Calcium Metabolism ( A. W. Norman, K. Schaefer, D. V. Herrath, and H.-G. Grigoleit, eds.), Walter de Gruyter Verlag, Berlin and New York, pp. 305–307.

    Google Scholar 

  • Goodman, D. B. P., Haussier, M. R., and Rasmussen, H., 1972, Vitamin D3 induced alteration of microvillar membrane lipid composition, Biochem. Biophys. Res. Commun. 46: 80–86.

    PubMed  CAS  Google Scholar 

  • Hammerman, M. R., and Hruska, K. A., 1982, Cyclic AMP-dependent protein phosphorylation in canine renal brush-border membrane vesicles is associated with decreased phosphate transport, J. Biol. Chem. 257: 992–999.

    PubMed  CAS  Google Scholar 

  • Harrison, H. E., and Harrison, H. C., 1961, Intestinal transport of phosphate: Action of vitamin D, calcium and potassium. Am. J. Physiol. 201: 1007–1012.

    PubMed  CAS  Google Scholar 

  • Harrison, H. E., and Harrison, H. C., 1963, Sodium, potassium, and intestinal transport of glucose, 1-tyrosine, phosphate and calcium, Am. J. Physiol. 205: 107–111.

    PubMed  CAS  Google Scholar 

  • Harter, H. R., Mercado, A., Rutherford, W. E., Rodriguez, H., Slatopolsky, E., and Klahr, S., 1974, Effects of phosphate depletion and parathyroid hormone on renal glucose absorption. Am. J. Phsyiol. 227: 1422–1427.

    CAS  Google Scholar 

  • Haussler, M. R., and McCain, T. A., 1977, Basic and clinical concepts related to vitamin D metabolism and action, New Engl. J. Med. 297: 1041–1050.

    PubMed  CAS  Google Scholar 

  • Haussier, M. R., Baylink, D. J., Hughes, M. R., Brumbaugh, P. F., Wergedal, J. E., Shen, F. H., Nielsen, R. L., Counts, S. J., Bursac, K. M., and McCain, T. A., 1976, The assay of la,25dihydroxyvitamin D3: Physiology and pathologic modulation of circulating hormone levels, Clin. Endocrinol. 5:151 s-165s.

    Google Scholar 

  • Hildmann, B., Storelli, C., Danisi, G., and Murer, H., 1982, Regulation of Na+-P; cotransport by 1,25-dihydroxyvitamin D3 in rabbit duodenal brush-border membrane, Am. J. Physiol. 242: G533 — G539.

    PubMed  CAS  Google Scholar 

  • Hirsch, P. F., and Munson, P. L., 1969, Thyrocalcitonin, Physiol. Rev. 49: 548–622.

    PubMed  CAS  Google Scholar 

  • Hoffmann, N., Thees, M., and Kinne, R., 1976, Phosphate transport by isolated renal brush border vesicles, Pflügers Arch. 362: 147–156.

    PubMed  CAS  Google Scholar 

  • Hughes, M. R., Brumbaugh, P. F., Haussier, M. R., Wergedal, J. E., and Baylink, D. J., 1975, Regulation of serum la,25-dihydroxyvitamin D3 by calcium and phosphate in the rat, Science 190: 578–580.

    PubMed  CAS  Google Scholar 

  • Hurwitz, S., and Bar, A., 1972, Site of vitamin D action in chick intestine, Am. J. Physiol. 222: 761–767.

    PubMed  CAS  Google Scholar 

  • Innes, J. R. M., and Nicolaysen, R.,1937, The assimilation of the Steenblock-Black diet in normal and itamin D-deficient rats with and without caecum, Biochem. J. 31:101–104.Jackson, M. J., and Kutcher, L. M., 1977, The three-compartment system for transport of weak electrolytes in the small intestine, in: Intestine Permeation (M. Kramer, and F. Lankbach, eds.), Excerpta Medica, Amsterdam and Oxford, pp. 65–73..

    Google Scholar 

  • Jacobi, H., Rummel, W., and Pfleger, K., 1958, Die Beziehungen zwischen Phosphatdurchtritt und Glu-coseresorption, Naunyn-Schmiedeberg’s Arch. Exp. Pathol. Pharmakol. 234: 404–413.

    PubMed  CAS  Google Scholar 

  • Juan, D., Liptak, P., and Gray, T. K., 1976, Absorption of inorganic phosphate in human jejunum and its inhibition by salmon calcitonin, J. Clin. Endocrinol. Metabol. 43: 517–522.

    CAS  Google Scholar 

  • Karsenty, G., Ulmann, A., Lacour, B., Pierandrei, E., and Drueke, T., 1982, Early stimulation by 1,25(OH)2D3 of 33P, uptake by isolated enterocytes, in: Vitamin D: Chemical, Biochemical and Clinical Endocrinology of Calcium Metabolism ( A. W. Norman, K. Schaefer, D. v. Herrath, and H.-G. Grigoleit, eds.), Walter de Gruyter Verlag, Berlin and New York, pp. 345–347.

    Google Scholar 

  • Kessler, R. J., and Fanestil, D. D., 1981, Identification of a phosphate-binding proteolipid in kidney brush border, in: Calcium and Phosphate Transport Across Biomembranes ( F. Bronner and M. Peterlik, eds.), Academic Press, New York, pp. 123–126.

    Google Scholar 

  • Kessler, R. J., Vaughn, D. A., and Fanestil, D. D., 1982, Phosphate binding proteolipid from brush-border, J. Biol. Chem. 257: 14311–14317.

    PubMed  CAS  Google Scholar 

  • Kinne, R., 1982, Calcium and phosphate transport across renal plasma membranes: Concepts, problems and future developments, in: Calcium and Phosphate Transport Across Biomembranes ( F. Bronner and M. Peterlik, eds.), Academic Press, New York, pp. 105–110.

    Google Scholar 

  • Knight, T. F., Senekjian, H. O., Sansom, S., and Weinman, E. J., 1980, Influence of D-glucose on phosphate absorption in the rat proximal tubule, Min. Electrolyte Metabol. 4: 37–42

    CAS  Google Scholar 

  • Kowarski, S., and Schachter, D. 1969, Effects of vitamin D on phosphate transport and incorporation into mucosal constituents of rat intestinal mucosa, J. Biol. Chem. 244: 211–217.

    PubMed  CAS  Google Scholar 

  • Lawson, D. E. M., 1978, Biochemical responses of the intestine to vitamin D, in: Vitamin D ( D. E. M. Lawson, ed.), Academic Press, London, pp. 167–200.

    Google Scholar 

  • Lee, D. B. N., Walling, M. W., Gafter, U., Silis, V., and Coburn, J. W., 1980, Calcium and inorganic phosphate transport in rat colon. Dissociated response to 1,25-dihydroxyvitamin D3, J. Clin. Invest. 65: 1326–1331.

    PubMed  CAS  Google Scholar 

  • Letellier, M., Plante, G. E., Briere, N., and PetitClerc, C., 1982, Participation of alkaline phosphatase in the active transport of phosphates in brush border membrane vesicles, Biochem. Biophys. Res. Commun. 108: 1394–1400.

    PubMed  CAS  Google Scholar 

  • Lewis, K. 0., 1973, The nature of the copper complexes in bile and their relationship to the absorption and excretion of copper in normal subjects and in Wilson’s disease, Gut 14: 221–232.

    PubMed  CAS  Google Scholar 

  • Liedtke, C. M., and Hopfer, U., 1977, Anion transport in brush border membranes isolated from rat small intestine, Biochem. Biophys. Res. Commun. 76: 579–585.

    CAS  Google Scholar 

  • Lifshitz, F., Harrison, H. C., and Harrison, H. E., 1969, Influence of parathyroid function upon the in vitro transport of calcium and phosphate by the rat intestine, Endocrinology 84: 912–917.

    PubMed  CAS  Google Scholar 

  • Lobao, A. O., Vitti Marcondes, D. M. S. S., Lemos, J. W., Peixoto Escubedo, M. I. B., de Oliveira, A. A. D., and Binnerts, W. T., 1982, The use of phosphorus-32 in the diagnosis of phosphorus deficiency in sheep, in: The Use of Isotopes to Detect Moderate Mineral Imbalances in Farm Animals, IAEATECDOC-267 (A Technical Document issued by the International Atomic Energy Agency), Vienna, 1982, pp. 33–48.

    Google Scholar 

  • Long, R. G., Varghese, Z., Skinner, R. K., Wills, M. R., and Sherlock, S., 1978, Phosphate metabolism in chronic liver disease, Clin. Chim. Acta 87: 353–358.

    PubMed  CAS  Google Scholar 

  • Lücke, H., Stange, G., and Murer, H., 1981, Sulfate-sodium cotransport by brush-border membrane vesicles isolated from rat ileum, Gastroenterology 80: 22–30.

    PubMed  Google Scholar 

  • MacHardy, G. J. R., and Parsons, D. S., 1956, The absorption of inorganic phosphate from the small intestine of the rat, Quart. J. Exp. Physiol. 41: 398–409.

    Google Scholar 

  • Marcinowska-Suchowierska, E., Lorenc, R. S., and Gray, T. K., 1981, Deal calcium and phosphate absorption in chronic renal failure, in: Calcium and Phosphate Transport across Biomembranes ( F. Bronner and M. Peterlik, eds.), Academic Press, New York, pp. 167–170.

    Google Scholar 

  • Massry, S. G., 1978, The clinical syndrome of phosphate depletion, in: Homeostasis of Phosphate and Other Minerals ( S. G. Massry, E. Ritz, and A. Rapado, eds.), Plenum Press, New York, pp. 301–312.

    Google Scholar 

  • Matsumoto, T., Fontaine, 0., and Rasmussen, H., 1980, Effect of 1,25-dihydroxyvitamin D-3 on phosphate uptake into chick intestinal brush border membrane vesicles, Biochim. Biophys. Acta 599: 13–23.

    CAS  Google Scholar 

  • Max, E. E., Goodman, D. B. P., and Rasmussen, H., 1978, Purification and characterization of chick intestine brush border membrane. Effects of la(OH)vitamin D3 treatment, Biochim. Biophys. Acta 511: 224–239.

    PubMed  CAS  Google Scholar 

  • Moog, F., and Glazier, H. S., 1972, Phosphate absorption and alkaline phosphatase activity in the small intestine of the adult mouse and of the chick embryo and hatched chick, Comp. Biochem. Physiol. 42A: 321–336.

    CAS  Google Scholar 

  • Morgan, D. B., 1969, Calcium and phosphorus transport across the intestine, in: Malabsorption ( R. H. Girdwood and A. N. Smith, eds.), Williams and Wilkins, Baltimore, pp. 74–91.

    Google Scholar 

  • Nicolaysen, R., 1937a, A note on the calcium and phosphate requirement of rachitic rats, Biochem. J. 31: 105–106.

    PubMed  CAS  Google Scholar 

  • Nicolaysen, R., 1937b, Studies upon the mode of action of vitamin D. II. The influence on the faecal output of endogenous calcium and phosphorus in the rat, Biochem. J. 31: 107–121.

    PubMed  CAS  Google Scholar 

  • Nicolaysen, R., 1937c, Studies on the mode of action of vitamin D. V. The absorption of phosphates from isolated loops of the small intestine in the rat, Biochem. J. 31: 1086–1088.

    PubMed  CAS  Google Scholar 

  • Norman, A. W., Mircheff, A. K., Adams, T. H., and Spielvogel, A., 1970, Studies on the mechanism of action of calciferol. III. Vitamin D-mediated increase of intestinal brush border alkaline phosphatase activity, Biochim. Biophys. Acta 215: 348–359.

    PubMed  CAS  Google Scholar 

  • Norman, A. W., Putkey, J. A., and Nemere, I., 1981, Vitamin D-mediated intestinal calcium transport: Analysis of the complexity of the process, in: Calcium and Phosphate Transport across Biomembranes ( F. Bronner and M. Peterlik, eds.), Academic Press, New York, p. 263–268.

    Google Scholar 

  • O’Doherty, P. J. A., DeLuca, H. F., and Eicher, E. M., 1977, Lack of effect of vitamin D and its metabolites on intestinal phosphate transport in familial hypophosphatemia of mice, Endocrinology 101: 1325–1330.

    Google Scholar 

  • Peterlik, M., 1978a, Vitamin D-dependent phosphate transport by chick intestine: Inhibition by low sodium and N-ethylmaleimide, in: Homeostasis of Phosphate and Other Minerals ( S. G. Massry, E. Ritz, and A. Rapado, eds.), Plenum Press, New York, pp. 149–159.

    Google Scholar 

  • Peterlik, M., 1978b, Phosphate transport by embryonic chick duodenum: Stimulation by vitamin D3, Biochim. Biophys. Acta 514: 164–171.

    PubMed  CAS  Google Scholar 

  • Peterlik, M., and Wasserman, R. H., 1975, Basic features of the vitamin D-dependent phosphate transport by chick jejunum in vitro, Fed. Proc. 34: 887.

    Google Scholar 

  • Peterlik, M., and Wasserman, R. H., 1977, Effect of vitamin D3 and 1,25-dihydroxyvitamin D3 on intestinal transport of phosphate, in: Phosphate Metabolism ( S. G. Massry and E. Ritz, eds.), Plenum Press, New York, pp. 323–332.

    Google Scholar 

  • Peterlik, M., and Wasserman, R. H., 1978a, Effect of vitamin D on transepithelial phosphate transport in chick intestine, Am. J. Phvsiol. 234: E379–388.

    CAS  Google Scholar 

  • Peterlik, M., and Wasserman, R. H., 1978b, Stimulatory effect of 1,25-dihydroxycholecalciferol-like substances from Solanum malacoxylon and Cestrum diurnum on phosphate transport in chick jejunum, J. Nutr. 108: 1673–1679.

    PubMed  CAS  Google Scholar 

  • Peterlik, M., and Wasserman, R. H., 1980, Regulation by vitamin D of intestinal phosphate absorption. Horm. Metabol. Res. 12: 216–219.

    CAS  Google Scholar 

  • Peterlik, M., Fuchs, R., and Cross, H. S., 1981a, Phosphate transport in intestine: Cellular pathways and hormonal regulation, in: Calcium and Phosphate Transport across Biomembranes F. Bronner and M. Peterlik, Academic Press, New York, pp. 173–179.

    Google Scholar 

  • Peterlik, M., Cross, H. S., and Fuchs, R., 1982a, Vitamin D and intestinal transport of phosphate, D-glucose and sodium, in: Electrolyte and Water Transport Across Gastrointestinal Epithelia (M. R. Case, A. Garner, L. A. Turnberg and J. A. Young, eds.), Raven Press, New York, pp. 305–308.

    Google Scholar 

  • Peterlik, M., Cross, H. S., and Fuchs, R., 1982b, Effects of vitamin D on pathways of epithelial sodium transport in chick small intestine, Naunyn-Schmiedeberg’s Arch. Pharmacol. 321 (Suppl.): R57.

    Google Scholar 

  • Pfleger, K., Rummel, W., and Jacobi, H., 1958, Phosphatdurchtritt am isolierten Darm unter Dinitrophenol und Thyroxin, Biochem. Z. 330: 303–309.

    CAS  Google Scholar 

  • Rizzoli, R., Fleisch, H., and Bonjour, J.-P., 1977, Role of 1,25-dihydroxyvitamin D3 on intestinal phosphate absorption in rats with a normal vitamin D supply, J. Clin. Invest. 60: 639–647.

    PubMed  CAS  Google Scholar 

  • Rose, R. C., and Schultz, S. G., 1971, Studies on the electrical potential profile across rabbit ileum, J. Gen. Phvsiol. 57: 639–663.

    CAS  Google Scholar 

  • Schultz, S. G., 1979, Transport across small intestine, in: Membrane Transport in Biology ( G. Giebisch, D. C. Tosteson, and H. H. Ussing, eds.), Springer-Verlag, Berlin, Heidelberg, New York, pp. 749–780.

    Google Scholar 

  • Short, E. M., Binder, H. J., and Rosenberg, L. E., 1973, Familial hypophosphatemic rickets: Defective transport of inorganic phosphate by intestinal mucosa, Science 179: 700–702.

    PubMed  CAS  Google Scholar 

  • Skadhauge, E., and Thomas, D. H., 1979, Transepithelial transport of K’, NH4’, inorganic phosphate and water by hen (Gallus domesticus) lower intestine (colon and coprodeum) perfused luminally in vivo, Pfluegers Arch. 379: 237–243.

    CAS  Google Scholar 

  • Soergel, K. H. and Hofmann, A. F., 1972, Absorption, in: Pathophysiology (E. D. Frohlich, ed.), J. B. Lippincott, Philadelphia and Toronto, pp. 423–453.

    Google Scholar 

  • Sonnenberg, A.,v. Lilienfeld-Toal, H., Sonnenberg, G. E., Rohner, H. G., and Strohmeyer, G., 1977, Serum 25-hydroxyvitamin D3 levels in patients with liver disease, Acta Hepato-Gastroenterol. 24: 256–258.

    CAS  Google Scholar 

  • Steele, T. H. 1977, Independence of phosphate homeostasis from parathyroid function in the phosphate-depleted rat, in: Phosphate Metabolism (S. G. Massry and E. Ritz, eds.), Plenum Press, New York, pp. 183–192.

    Google Scholar 

  • Tanzer, F. S., and Navia, J. M., 1973, Calcitonin inhibition of intestinal phosphate absorption, Nature 242: 221–222.

    CAS  Google Scholar 

  • Taylor, A. N., 1974, In vitro phosphate transport in chick ileum: Effect of cholecalciferol, calcium, sodium and metabolic inhibitors, J. Nutr. 104: 489–494.

    CAS  Google Scholar 

  • Tenenhouse, H.S., and Scriver, C. R., 1978, The defect in transcellular transport of phosphate in the nephron is located in brush-border membranes in X-linked hypophosphatemia (Hyp mouse model), Can. J. Biochem. 56:640–646.

    PubMed  CAS  Google Scholar 

  • Tenenhouse, H. S., and Scriver, C. R., 1979, Renal brush border membrane adaptation to phosphorus deprivation in the Hyp/Y mouse, Nature 281: 225–227.

    PubMed  CAS  Google Scholar 

  • Tenenhouse, H. S., Fast, D. K., and Scriver, C. R., 1981, Effect of 1,25(OH)2D3 on renal and intestinal transport of phosphate anion in Hyp mouse, in: Calcium and Phosphate Transport across Biomembranes ( F. Bronner and M. Peterlik, eds.), Academic Press, New York, pp. 221–224.

    Google Scholar 

  • Tsuchiya, W., and Okada, Y., 1982, Membrane potential changes associated with differentiation of enterocytes in the rat intestinal villi in culture, Dev. Biol. 94: 284–290.

    PubMed  CAS  Google Scholar 

  • Walling, M. W., 1977, Intestinal Ca and phosphate transport: Differential response to vitamin D3 metabolites, Am. J. Physiol. 233: E488–494.

    PubMed  CAS  Google Scholar 

  • Walling, M. W., 1978, Intestinal inorganic phosphate transport, in: Homeostasis of Phosphate and Other Minerals ( S. G. Massry, E. Ritz, and A. Rapado, eds.), Plenum Press, New York, pp. 131–147.

    Google Scholar 

  • Walling, M. W., and Kimberg, D. V., 1975, Effects of la,25-dihydroxyvitamin D3 and Solanum glaucophyllum on intestinal calcium and phosphate transport and on plasma, Ca, Mg, and P levels in the rat, Endocrinology 97: 1567–1576.

    PubMed  CAS  Google Scholar 

  • Walling, M. W., Kimberg, D. V., Wasserman, R. H., and Feinberg, R. R., 1976, Duodenal active transport of calcium and phosphate in vitamin D-deficient rats: Effect of nephrectomy, Cestrum diurnum, and Ia,25-dihydroxyvitamin D3, Endocrinology 98: 1130–1134

    PubMed  CAS  Google Scholar 

  • Walser, M., 1961, Ion association. VI. Interactions between calcium,magnesium,inorganic phosphate,citrate and protein in normal human plasma, J. Clin. Invest. 40: 723–730.

    PubMed  CAS  Google Scholar 

  • Walton, J., and Gray, T. K., 1979, Absorption of inorganic phosphate in the human small intestine, Clin. Sci. Mol. Med. 56: 407–412.

    CAS  Google Scholar 

  • Wasserman, R. H., and Brindak, M. E., 1979, The effect of cholecalciferol on the phosphorylation of intestinal membrane proteins, in: Vitamin D. Basic Research and Its Clinical Application ( A. W. Norman, K. Schaefer, D.v. Herrath, H.-G. Grigoleit, J. W. Coburn, H. F. DeLuca, E. B. Mawer, and T. Suda, eds.), Walter de Gruyter Verlag, Berlin and New York, pp. 703–710.

    Google Scholar 

  • Wasserman, R. H., and Taylor, A. N., 1966, Vitamin D3-induced calcium-binding protein in chick intestine mucosa, Science 152: 791–793.

    PubMed  CAS  Google Scholar 

  • Wasserman, R. H., and Taylor, A. N., 1973, Intestinal absorption of phosphate in the chick: Effect of vitamin D3 and other parameters, J. Nutr. 103: 586–599.

    PubMed  CAS  Google Scholar 

  • Wasserman, R. H., Kallfelz, F. A., and Comar, C. L., 1961, Active transport of calcium by rat duodenum in vivo, Science 133: 883–884.

    PubMed  CAS  Google Scholar 

  • Wasserman, R. H., Taylor, A. N., and Kallfelz, F. A., 1966, Vitamin D and transfer of plasma calcium to intestinal lumen in chicks and rats, Am. J. Physiol. 211: 419–423.

    PubMed  CAS  Google Scholar 

  • Wasserman, R. H., Brindak, M. E., and Fullmer, C. S., 1981, Calcium-binding protein (CaBP) and other vitamin D-responsive proteins, in: Calcium and Phosphate Transport across Biomembranes ( F. Bronner and M. Peterlik, eds.), Academic Press, New York, pp. 279–287.

    Google Scholar 

  • Wertheim, A. R., Eurman, G. H., and Kalinsky, H. J., 1954, Changes in serum inorganic phosphorus during intravenous glucose tolerance tests: In patients with primary (essential) hypertension, other disease states, and in normal man, J. Clin. Invest. 33: 565–571.

    PubMed  CAS  Google Scholar 

  • Wilson, T. H., and Wiseman, G., 1954, The use of sacs of everted small intestine for the study of the transference of substances from the mucosal to the serosal surface, J. Physiol. 123: 116–125.

    PubMed  CAS  Google Scholar 

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© 1985 Plenum Press, New York

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Peterlik, M. (1985). Intestinal Phosphate Transport. In: Martonosi, A.N. (eds) The Enzymes of Biological Membranes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4601-2_8

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