Skip to main content
SpringerLink
Log in
Book cover

The Enzymes of Biological Membranes pp 449–495Cite as

H+-Translocating ATPase and Other Membrane Enzymes Involved in the Accumulation and Storage of Biological Amines in Chromaffin Granules

  • Chapter

Abstract

Within the adrenal medulla, catecholamines accumulate into and are stored within a highly specialized subcellular organelle, the chromaffin granule. Since their isolation almost 30 years ago, an interdisciplinary approach from pharmacologists, transport and cellular physiologists, electron microscopists, and anatomists has helped to delineate the salient aspects of the structure, composition, and function of these granules. One of the reasons for such profound interest is that the adrenal chromaffin granule has a common embryologic origin with the adrenergic neurotransmitter granules of the central and peripheral nervous system, suggesting that the two amine storage organelles may have functional properties in common.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abbs, M. T., and Phillips, J. H., 1980, Organization of the proteins of the chromaffin granule membrane, Biochim. Biophys. Acta 595: 200–221.

    PubMed  CAS  Google Scholar 

  • Aberer, W. H., Kostron, H., Huber, E., and Winkler, H., 1978, A characterization of the nucleotide uptake by chromaffin granules of bovine adrenal medulla, Biochem. J. 172: 353–360.

    PubMed  CAS  Google Scholar 

  • Apps, D. K., and Glover, L. A., 1978, Isolation and characterization of magnesium adenosinetriphosphatase from the chromaffin granule membrane, FEBS Lett. 85: 254–257.

    PubMed  CAS  Google Scholar 

  • Apps, D. K., and Schatz, G., 1979, An adenosine triphosphatase isolated from chromaffin granule membranes is closely similar to F1-adenosine triphosphatase of mitochondria, Eur. J. Biochem. 100: 411–419.

    PubMed  CAS  Google Scholar 

  • Apps, D. K., Pryde, J. G., and Phillips, J. H., 1980a, Both the transmembrane pH gradient and the membrane potential are important in the accumulation of amines by resealed chromaffin-granule “ghosts,” FEBS Lett. 111: 386–390.

    PubMed  CAS  Google Scholar 

  • Apps, D. K., Pryde, J. G., Sutton, R., and Phillips, J. H., 1980b, Inhibition of adenosine triphosphatase, 5-hydroxytryptamine transport, and proton translocation activities of resealed chromaffin granule ghosts, Biochem. J. 190: 273–282.

    PubMed  CAS  Google Scholar 

  • Bank, S. P., 1965, The adenosine-triphosphatase activity of adrenal chromaffin granules, Biochem. J. 95: 490.

    Google Scholar 

  • Bashford, C. L., Radda, G. K., and Ritchie, G. A., 1975, Energy-linked activities of the chromaffin granule membrane, FEBS Lett. 50: 21–24.

    PubMed  CAS  Google Scholar 

  • Bashford, C. L., Cassey, R. P., Radda, G. K., and Ritchie, G. A., 1976, Energy coupling in adrenal chromaffin granules, Neuroscience 1: 399–412.

    PubMed  CAS  Google Scholar 

  • Bock, E., and Helle, K. B., 1977, Localization of synoptin on synaptic vesicle membranes, synaptosomal plasma membranes, and chromaffin granule membranes, FEBS Len. 82: 175–178.

    CAS  Google Scholar 

  • Borowitz, J. L., 1967, Calcium binding by subcellular fractions of bovine adrenal medulla, J. Cell. Comp. Physiol. 69: 305–310.

    Google Scholar 

  • Borowitz, J. L., 1969, Effect of acetylcholine on the subcellular distribution of 45Ca~ * on bovine adrenal medulla, Biochem. Pharmacol. 18: 715–723.

    PubMed  CAS  Google Scholar 

  • Borowitz, J. L., Fuiva, K., and Weiner, N., 1965, Distribution of metals and catecholamines in bovine adrenal medulla sub-cellular fractions, Nature 205: 42–43.

    PubMed  CAS  Google Scholar 

  • Buckland, R. M., Radda, G. K., and Shennon, K. D., 1978, Accessibility of phospholipids in the chromaffin granule membrane, Biochim. Biophys. Acta 513: 321–337.

    PubMed  CAS  Google Scholar 

  • Buckland, R. M., Radda, G. K., and Wakefield, E. M., 1979, Reconstitution of the MgATPase of the chromaffin granule membrane, FEBS Leu. 103: 323–327.

    CAS  Google Scholar 

  • Buckley, J. T., Lefebre, Y. A., and Hawthorne, J. A., 1971, Identification of an actively phosphorylated component of adrenal medulla chromaffin granules, Biochim. Biophys. Acta 239: 517–519.

    PubMed  CAS  Google Scholar 

  • Cahill, A. L., and Morris, S. J., 1979, Soluble and membrane lectin-binding glycoproteins of the chromaffingranule, J. Neurochem. 32:855–867.

    Google Scholar 

  • Carty, S. E., Johnson, R. G., and Scarpa, A., 1980, The isolation of intact chromaffin granules using isotonic Percoll density gradients, Anal. Biochem. 106: 438–445.

    PubMed  CAS  Google Scholar 

  • Carty, S. E., Johnson, R. G., and Scarpa, A., 1981, Serotonin transport in isolated platelet granules: Coupling to the electrochemical proton gradient, J. Biol. Chem. 256: 11244–11250.

    PubMed  CAS  Google Scholar 

  • Carty, S. E., Johnson, R. G., and Scarpa, A., 1982, Electrochemical proton gradient in dense granules isolated from anterior pituitary, J. Biol. Chem. 257: 7269–7273.

    PubMed  CAS  Google Scholar 

  • Carty, S. E., Johnson, R. G., Vaugh T., Pallant, A., and Scarpa, A., 1984, Kinetic parameters of amine accumulation into chromaffin ghosts, Eur. J. Biochem. (submitted).

    Google Scholar 

  • Casey, R. P., Njus, D., Radda, G. K., and Sehr, P. A., 1976, Adenosine triphosphate-evoked catecholamine release in chromaffin granules, Biochem. J. 158: 583–588.

    PubMed  CAS  Google Scholar 

  • Casey, R. P., Njus, D., Radda, G. K., and Sehr, P. A., 1977a, Active proton uptake by chromaffin granules: Observation by amine distribution and phosphorus-31 nuclear magnetic resonance techniques, Biochemistry 16: 972–977.

    PubMed  CAS  Google Scholar 

  • Casey, R. P., Njus, D., Radda, G. K., and Sehr, P. A., 1977b, Adenosine triphosphate-evoked catecholamine release in chromaffin granules. Osmotic lysis as a consequence of proton translocation, Biochem. J. 158: 583–588.

    Google Scholar 

  • Coupland, R. E., and Hopwood, D., 1966, The mechanism for differential staining reaction for adrenaline-and noradrenaline-storing granules in tissue fixed in gluteraldehyde, J. Anat. 100: 227–243.

    PubMed  CAS  Google Scholar 

  • Craine, J. E., Daniels, G. H., and Kaufman, S., 1973, Dopamine-3-hydroxylase, the subunit structure and anion activation of the bovine adrenal enzyme, J. Biol. Chem. 248: 7838–7844.

    PubMed  CAS  Google Scholar 

  • Cross, R. L., 1981, The mechanism and regulation of ATP synthesis by F1 -ATPases, Annu. Rev. Biochem. 50: 681–714.

    PubMed  CAS  Google Scholar 

  • DaPrada, M., Obrist, R., and Pletscher, A., 1975, Discrimination of monoamine uptake by membranes of adrenal chromaffin granules, Br. J. Pharmacol. 53: 257–265.

    CAS  Google Scholar 

  • Deamer, D. N., Prince, R., and Crofts, A. R., 1972, The response of fluorescent amines to pH gradients across liposome membranes, Biochim. Biophys. Acta 274: 323–335.

    PubMed  CAS  Google Scholar 

  • DeOliveira-Filgueiras, O. M., van den Bosch, H., Johnson, R. G., Carty, S. E., and Scarpa, A., 1981, Phospholipid composition of some amine containing storage granules, FEBS Lett. 129: 309–313.

    CAS  Google Scholar 

  • Deupree, J. D., Weaver, J. A., and Downs, D. A., 1982, Catecholamine content of chromaffin granule “ghosts” isolated from bovine adrenal glands, Biochim. Biophys. Acta 714: 471–478.

    PubMed  CAS  Google Scholar 

  • Dolais-Kitabgi, J., and Perlman, R. L., 1975, The stimulation of catecholamine release from chromaffin granules by valinomycin, Mol. Pharmacol. 11: 745–750.

    PubMed  CAS  Google Scholar 

  • Duong, L. T., and Fleming, P. J., 1982, Isolation and properties of cytochrome 6561 from bovine adrenal chromaffin granules, J. Biol. Chem. 257: 8561–8564.

    PubMed  CAS  Google Scholar 

  • Eagles, P. A. M., Johnson, L. N., and van Horn, C., 1975, The distribution of concanavaline A receptor sites on the membrane of chromaffin granules, J. Cell Soc. 19: 33–34.

    CAS  Google Scholar 

  • Flatmark, T., and Gronberg, M., 1981, Cytochrome 6561 of the bovine adrenal chromaffin granules, Biochem. Biophys. Res. Commun. 99: 292–301.

    PubMed  CAS  Google Scholar 

  • Flatmark, T., and Ingebretsen, O. C., 1977, ATP dependent proton translocation in resealed chromaffin granule ghosts, FEBS Lett. 78: 53–56.

    PubMed  CAS  Google Scholar 

  • Flatmark, T., and Terland, O., 1971, Cytochrome b561 of the bovine adrenal chromaffin granule: A high potential b-type cytochrome, Biochim. Biophys. Acta 253: 487–491.

    PubMed  CAS  Google Scholar 

  • Gabizon, R., Yetinson, T., and Schuldiner, S., 1982, Photoinactivation and identification of the biogenic amine transporter in chromaffin granules from bovine adrenal medulla, J. Biol. Chem. 257: 15145–15150.

    PubMed  CAS  Google Scholar 

  • Geissler, D., Martinek, A., Margolis, R. U., Margolis, R. K., Shrivanek, J. A., Ledeen, R., Konig, P., and Winkler, H., 1977, Composition and biogenesis of complex carbohydrates of ox adrenal chromaffin granules, Neuroscience 2: 685–693.

    PubMed  CAS  Google Scholar 

  • Giraudat, J., Roisin, M., and Henry, J-P., 1980, Solubilization and reconstitution of the adenosine 5’-triphosphate dependent proton translocase of bovine chromaffin granule membrane, Biochemistry 19: 4499–4505.

    PubMed  CAS  Google Scholar 

  • Goldstein, M., Joh, T. H., and Gravey, T. Q., 1968, Kinetic studies of the enzyme dopamine-3 hydroxylation reaction, Biochemistry 7: 2724–2730.

    PubMed  CAS  Google Scholar 

  • Grouselle, M., and Phillips, J. H., 1982, Reduction of membrane bound dopamine-ß-hydroxylase from the cytoplasmic surface of the chromaffin granule membrane, Biochem. J. 202: 759–770.

    PubMed  CAS  Google Scholar 

  • Hausler, R., Burger, A., and Niedermaier, W., 1981, Evidence for an inherent, ATP-stimulated uptake of calcium into chromaffin granules, Naunyn-Schmiedeberg’s Arch. Pharmacol. 315: 255–267.

    PubMed  CAS  Google Scholar 

  • Hayflick, S., Johnson, R. G., Carty, S. E., and Scarpa, A., 1981, Kinetic and quantitative measurements of catecholamine transport in chromaffin ghosts using a catecholamine electrode, Anal. Biochem. 126: 58–66.

    Google Scholar 

  • Helle, K. B., Serck-Hanssen, G., and Boch, E., 1978, Complexes of chromogranin A and dopamine-ß-hydroxylase among the chromogranins of the bovine adrenal medulla, Biochim. Biophys. Acta 533: 396–407.

    PubMed  CAS  Google Scholar 

  • Holz, R. W., 1978, Evidence that catecholamine transport into chromaffin vesicles is coupled to vesicle membrane potential, Proc. Natl. Acad. Sci. USA 75: 5190–5194.

    PubMed  CAS  Google Scholar 

  • Holz, R. W., 1979, Measurement of membrane potential of chromaffin granules by the accumulation of triphenyl methylphosphonium cations, J. Biol. Chem. 254: 6703–6709.

    PubMed  CAS  Google Scholar 

  • Hornig, D., 1975, Distribution of ascorbic acid, metabolites, and analogs in man and animals, Ann. N.Y. Acad. Sci. 258: 103–118.

    PubMed  CAS  Google Scholar 

  • Hortnagl, H., Winkler, H., and Lochs, H., 1973, Membrane proteins of chromaffin granules. Dopaminebeta-hydroxylase, a major constituent, Biochem. J. 129: 187–195.

    Google Scholar 

  • Huber, E., Konig, P., Schuler, G., Aberer, W., Plattner, H., and Winkler, H., 1979, Characterization and topography of the glycoproteins of adrenal chromaffin granules, J. Neurochem. 32: 35–417.

    PubMed  CAS  Google Scholar 

  • Hughes, R. E., and Maton, S. C., 1968, The passage of vitamin C across the erythrocyte membrane, Br. J. Haematol. 14: 247–253.

    PubMed  CAS  Google Scholar 

  • Hutton, J. C., 1982, The internal pH and membrane potential of the insulin-secretory granule, Biochem. J. 204: 171–178.

    PubMed  CAS  Google Scholar 

  • Hutton, J. C., and Peshavaria, M., 1982, Proton-translocating Mg’-dependent ATPase activity in insulin-secretory granules, Biochem. J. 204: 161–170.

    PubMed  CAS  Google Scholar 

  • Ingebretsen, O. C., and Flatmark, T., 1979, Active and passive transport of dopamine in chromaffin granule ghosts isolated from bovine adrenal medulla, J. Biol. Chem. 254: 3833–3839.

    PubMed  CAS  Google Scholar 

  • Ingebretsen, O. C., Terland, O., and Flatmark, T., 1980, Subcellular distribution of ascorbate in bovine adrenal medulla. Evidence for accumulation in chromaffin granules against a concentration gradient, Biochim. Biophys. Acta 628: 182–189.

    PubMed  CAS  Google Scholar 

  • Izumi, F., Oka, M., Morita, K., and Azuma, H., 1975, Catecholamine releasing factor in bovine adrenal medulla, FEBS Lett. 56: 73–76.

    PubMed  CAS  Google Scholar 

  • Jockusch, B. M., Burger, M. M., DaPrada, M., Richards, J. G., Chaponnier, C., and Gabbiani, G., 1977, Alpha-actin attached to membranes of secretory vesicles, Nature 270: 628–629.

    PubMed  CAS  Google Scholar 

  • Johnson, R. G., and Scarpa, A., 1976, Ion permeability of isolated chromaffin granules, J. Gen. Physiol. 68: 601–631.

    PubMed  CAS  Google Scholar 

  • Johnson, R. G., and Scarpa, A., 1979, Protonmotive force and catecholamine transport in isolated chromaffin granules, J. Biol. Chem. 254: 3750–3760.

    PubMed  CAS  Google Scholar 

  • Johnson, R. G., and Scarpa, A., 1981, The electron transport chain of serotonin dense granules of platelets, J. Biol. Chem. 256: 11966–11969.

    PubMed  CAS  Google Scholar 

  • Johnson, R. G., Carlson, N., and Scarpa, A., 1978, ApH and catecholamine distribution in isolated chromaffin granules, J. Biol. Chem. 253: 15120–15121.

    Google Scholar 

  • Johnson, R. G., Pfister, D., Carty, S. E., and Scarpa, A., 1979, Biological amine transport in chromaffin ghosts, J. Biol. Chem. 254: 10963–10972.

    PubMed  CAS  Google Scholar 

  • Johnson, R. G., Carty, S. E., Fingerhood, B., and Scarpa, A., 1980, The internal pH of mast cell granules, FEBS Lett. 120: 75–79.

    PubMed  CAS  Google Scholar 

  • Johnson, R. G., Carty, S. E., and Scarpa, A., 1981, Proton: substrate stoichiometries during active transport of biogenic amines in chromaffin ghosts, J. Biol. Chem. 256: 5773–5780.

    PubMed  CAS  Google Scholar 

  • Johnson, R. G., Beers, M. F., and Scarpa, A., 1982a, H+ ATPase of chromaffin granules: Kinetics, regulation, and stoichiometry, J. Biol. Chem. 257: 10701–10707.

    PubMed  CAS  Google Scholar 

  • Johnson, R. G., Carty, S. E., and Scarpa, A., 1982b, Catecholamine transport and energy-linked function

    Google Scholar 

  • of chromaffin granules isolated from a human pheochromocytoma, Biochim. Biophys. Acta 716:366–376.

    Google Scholar 

  • Johnson, R. G., Hayflick, S., Carty, S. E., and Scarpa, A., 1982c, Net uptake of catecholamines into isolated chromaffin granules demonstrated by a novel polarographic technique, FEBS Lett. 141: 63–67.

    PubMed  CAS  Google Scholar 

  • Johnson, R. G., Carty, S. E., and Scarpa, A., 1982d, The electrochemical proton gradient and catecholamine accumulation into isolated chromaffin granules and ghosts, in: Membranes and Transport: A Critical Review ( A. Martonosi, ed.), Plenum, New York, pp. 237–244.

    Google Scholar 

  • Johnson, R. G., Carty, S. E., and Scarpa, A., 1984, Kinetic parameters of uptake of various biological amines in isolated chromaffin granules, manuscript in preparation.

    Google Scholar 

  • Jonasson, J., Rosengren, E., and Waldeck, B., 1964, Effects of some pharmacologically active amines on the uptake of arylalkylamines by adrenal medullary granules, Acta Physiol. Scand. 60: 136–140.

    PubMed  CAS  Google Scholar 

  • Kanner, B. I., Fishkes, H., Maron, R., Sharon, I., and Schuldiner, S., 1979, Reserpine as a competitive and reversible inhibitor of the catecholamine transporter of bovine chromaffin granules, FEBS Lett. 100: 175–178.

    PubMed  CAS  Google Scholar 

  • Kanner, B. I., Sharon, I., Maron, R., and Schuldiner, S., 1980, Electrogenic transport of biogenic amines in chromaffin granule membrane vesicles, FEBS Leu. 111: 83–86.

    CAS  Google Scholar 

  • Kirshner, N., 1962, Uptake of catecholamines by a particulate fraction of the adrenal medulla, J. Biol. Chem. 237: 2311–2317.

    PubMed  CAS  Google Scholar 

  • Knoth, J., Handloser, K., and Njus, D., 1980, Electrogenic epinephrine transport in chromaffin granule ghosts, Biochemistry 19: 2938–2942.

    PubMed  CAS  Google Scholar 

  • Knoth, J., Isaacs, J. M., and Njus, D., 1981, Amine transport in chromaffin granule ghosts, J. Biol. Chem. 256: 6541–6543.

    PubMed  CAS  Google Scholar 

  • Kostron, H., Winkler, H., Geissler, D., and Konig, P., 1977a, Uptake of calcium by chromaffin granules in vitro, J. Neurochem. 23: 487–493.

    Google Scholar 

  • Kostron, H., Winkler, H., Peer, L. J., and Konig, P., 1977b, Uptake of adenosine triphosphate by isolated adrenal chromaffin granules: A carrier-mediated transport, Neuroscience 2: 159–166.

    PubMed  CAS  Google Scholar 

  • Krieger-Brauer, H., and Gratzl, M., 1982, Uptake of Ca++ by isolated secretory vesicles from adrenal medulla, Biochim. Biophys. Acta 691: 61–70.

    PubMed  CAS  Google Scholar 

  • Lishajko, F., 1971, Studies on catecholamine release and uptake in adreno-medullary storage granules, Acta Physiol. Scand. 362 (Suppl.): 3–39.

    Google Scholar 

  • Livett, B. G., Dean, D. M., Whelan, L. G., Udenfriend, S., and Bossier, J., 1981, Co-release of enkephalin and catecholamine from cultured adrenal chromaffin cells, Nature 289: 317–319.

    PubMed  CAS  Google Scholar 

  • Lundborg, P., 1966, Uptake of metaraminol by the adrenal medullary granules, Acta Physiol. Scand. 67: 423–429.

    PubMed  CAS  Google Scholar 

  • Margolis, R. U., and Margolis, R. K., 1973, Isolation of chondroitin sulfate and glycopeptides from chromaffin granules of adrenal medulla, Biochem. Pharmacol. 22: 2195–2197.

    PubMed  CAS  Google Scholar 

  • Maron, R., Fishkes, H., Kanner, B. I., and Schuldiner, S., 1979, Solubilization and reconstitution of the catecholamine transporter from bovine chromaffin granules, Biochemistry 18: 4781–4785.

    PubMed  CAS  Google Scholar 

  • Michaelson, D. M., and Angel, I., 1980, Determination of ApH in cholinergic synaptic vesicles: Its effect on storage and release of acetylcholine, Life Sci. 27: 39–44.

    PubMed  CAS  Google Scholar 

  • Mitchell, P., 1961, Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism, Nature 191: 144–148.

    PubMed  CAS  Google Scholar 

  • Mitchell, P., 1968, Chemiosmotic Coupling and Energy Transduction, Glynn Research, Bodmin, Cornwall.

    Google Scholar 

  • Morris, S. J., and Schovanka, I., 1977, Some physical properties of adrenal medulla chromaffin granules isolated by a new continuous iso-osmotic density gradient method, Biochim. Biophys. Acta 464: 53–64.

    Google Scholar 

  • Muller, T. W., and Kirshner, N., 1975, ATPase and phosphatidylinositol kinase activities of adrenal chromaffin vesicles, J. Neurochem. 24: 1155–1161.

    PubMed  CAS  Google Scholar 

  • Nichols, J. W., and Deamer, D. W., 1976, Catecholamine uptake and concentration by liposomes maintaining pH gradients, Biochim. Biophys. Acta 455: 269–271.

    PubMed  CAS  Google Scholar 

  • Niedermaier, W., and Burger, A., 1981, Two different ATP-dependent mechanisms for calcium uptake into chromaffin granules and mitochondria, Naunyn-Schmiedeberg’s Arch. Pharmacol. 316 (1): 69–80.

    PubMed  CAS  Google Scholar 

  • Njus, D., and Radda, G. K., 1978, Bioenergetic processes in chromaffin granules: A new perspective on some old problems, Biochim. Biophys. Acta 219–244.

    Google Scholar 

  • Njus, D., and Radda, G. K., 1979, A potassium ion diffusion potential causes adrenaline uptake into chromaffin granule “ghosts,” Biochem. J. 180: 579–585.

    PubMed  CAS  Google Scholar 

  • Njus, D., Sehr, P. A., Radda, G. K., Ritchie, G. M., and Seeling, R. J., 1978, Phosphorous-31 nuclear magnetic resonance studies of active proton translocation in chromaffin granules, Biochemistry 17: 4337–4343.

    PubMed  CAS  Google Scholar 

  • Njus, D., Knoth, J., and Zallakian, M., 1981, Proton-linked transport in chromaffin granules, Curr. Top. Bioenerg. 13: 107–145.

    Google Scholar 

  • Njus, D., Knoth, J., Cook, C., and Kelly, P. M., 1983, Electron transfer across the chromaffin granule membrane, J. Biol. Chem. 258: 27–30.

    PubMed  CAS  Google Scholar 

  • Parsons, S. M., and Koenigsberger, R., 1980, Specific stimulated uptake of acetylcholine by Torpedo electric organ synaptic vesicles, Proc. Natl. Acad. Sci. USA 77: 6234–6238.

    PubMed  CAS  Google Scholar 

  • Pazoles, C. J., Creutz, C. E., Ramu, A. and Pollard, H. B., 1980, Permeant anion activation of Mg, ATPase activity in chromaffin granules, J. Biol. Chem. 255: 7863–7869.

    PubMed  CAS  Google Scholar 

  • Perlman, R. L., and Sheard, B. E., 1982, Estimation of the cytoplasmic catecholamine concentration in pheochromocytoma cells, Biochim. Biophys. Acta 719: 334–340.

    PubMed  CAS  Google Scholar 

  • Phillips, J. H., 1973, Phosphatidyl kinase, a component of the chromaffin granule membrane, Biochem. J. 136: 579–587.

    PubMed  CAS  Google Scholar 

  • Phillips, J. H., 1974a, Transport of catecholamines by resealed chromaffin-granule “ghosts,” Biochem. J. 144: 311–318.

    PubMed  CAS  Google Scholar 

  • Phillips, J. H., 1974b, Steady-state kinetics of catecholamine transport by chromaffin granule “ghosts,” Biochem. J. 144: 319–325.

    PubMed  CAS  Google Scholar 

  • Phillips, J. H., 1977a, 5-Hydroxytryptamine transport by the bovine chromaffin granule membrane, Biochem. J. 170:673–679.

    Google Scholar 

  • Phillips, J. H., 1977b, Passive ion permeability of the chromaffin granule membrane, Biochem. J. 186: 289–297.

    Google Scholar 

  • Phillips, J. H., 1981, Transport of Cam ~ and Na across the chromaffin granule membrane, Biochem. J. 200: 99–107.

    PubMed  CAS  Google Scholar 

  • Phillips, J. H., 1982, Dynamic aspects of chromaffin granule structure, Neuroscience 7: 1595–1609.

    PubMed  CAS  Google Scholar 

  • Phillips, J. H., and Allison, Y. P., 1977, The distribution of calcium, magnesium, copper, and iron in the bovine adrenal medulla, Neuroscience 2: 147–152.

    PubMed  CAS  Google Scholar 

  • Phillips, J. H., and Allison, Y. P., 1978, Proton translocation by the bovine chromaffin-granule membrane, Biochem. J. 170: 661–672.

    PubMed  CAS  Google Scholar 

  • Pletscher, A., DaPrada, M., Steffen, H., Lutold, B., and Berneis, K. H., 1973, Mechanism of catecholamine accumulation in adrenal chromaffin granules, Brain Res. 62: 317–326.

    PubMed  CAS  Google Scholar 

  • Pletscher, A., DaPrada, M., Berneis, K. H., Steffen, H., Lutold, B., and Weder, H. G., 1974, Molecular organization of amine storage organelles of blood platelets and adrenal medulla, Adv. Cytol. Pharmacol. 2: 257–264.

    CAS  Google Scholar 

  • Pollard, H. B., Miller, A., and Cox, G. C., 1973, Synaptic vesicles: Structure of chromaffin granule membranes, J. Supramol. Struct. 1: 295–306.

    PubMed  CAS  Google Scholar 

  • Pollard, H. B., Zinder, O., Hoffman, P. G., and Nikodejevic, O., 1976, Regulation of the transmembrane potential of isolated chromaffin granules by ATP, ATP analogs, and external pH, J. Biol. Chem. 251: 4544–4550.

    PubMed  CAS  Google Scholar 

  • Pollard, H. B., Shindo, H., Creutz, C. E., Pazoles, C. T., and Cohen, J. S., 1979, Internal pH and state of ATP in adrenergic chromaffin granules determined by 31P nuclear magnetic resonance spectroscopy, J. Biol. Chem. 254: 1170–1177.

    PubMed  CAS  Google Scholar 

  • Price, H., Kinder, S., and Ledeen, R., 1975, Structure of gangliosides from bovine adrenal medulla, Biochemistry 14: 1512–1518.

    PubMed  CAS  Google Scholar 

  • Ramu, A., Levine, M., and Pollard, H., 1983, Proc. Natl. Acad. Sci. USA 80: 2107–2111.

    PubMed  CAS  Google Scholar 

  • Reed, P. W., and Lardy, H. A., 1972, A23187: A divalent cation ionophore, J. Biol. Chem. 247: 6970–6977.

    PubMed  CAS  Google Scholar 

  • Ritchie, G. A., 1975, Ph.D. thesis, University of Oxford, Oxford, England.

    Google Scholar 

  • Roda, L. G., and Hogue-Angeletti, R. A., 1979, Peptides in the adrenal medulla chromaffin granule, FEBS Lett. 107: 393–397.

    PubMed  CAS  Google Scholar 

  • Roisin, M. P., Scherman, D., and Henry, J.-P., 1980, Synthesis of ATP by an artificially imposed electrochemical proton gradient in chromaffin granule ghosts, FEBS Lett. 115: 143–146.

    PubMed  CAS  Google Scholar 

  • Rosenberg, R. C., and Lovenberg, W., 1980, Dopamine-3-hydroxylase, Essays Neurochem. Neuropharmacol. 4: 163–209.

    PubMed  CAS  Google Scholar 

  • Rottenberg, H., 1980, The measurement of membrane potential and ApH in cells, organelles, and vesicles, Meth. Enzymol. 5: 547–569.

    Google Scholar 

  • Rudnick, G., Fishkes, H., Nelson, P. J., and Schuldine, S., 1980, Evidence for two distinct serotonin transport systems in platelets, J. Biol. Chem. 255: 3638–3641.

    PubMed  CAS  Google Scholar 

  • Russell, J. T., and Holz, R. W., 1981, Measurement of OpH and membrane potential in isolated neurosecretory vesicles from bovine neurohypophyses, J. Biol. Chem. 256: 5950–5953.

    PubMed  CAS  Google Scholar 

  • Salama, G., Johnson, R. G., and Scarpa, A., 1979, Spectrophotometric measurements of transmembrane potential and pH gradients in chromaffin granules, J. Gen. Physiol. 75: 109–140.

    Google Scholar 

  • Scherman, D., and Henry, J.-P., 1979, Effet du potential trans-membranaire sur le transport de la noradrenaline par les granules chromaffines, C. R. Acad. Sci. (Paris) 289: 911–914.

    CAS  Google Scholar 

  • Scherman, D., and Henry, J.-P., 1980, Oxonol-V as a probe of chromaffin granule membrane potentials, Biochim. Biophys. Acta 599: 150–166.

    PubMed  CAS  Google Scholar 

  • Scherman, D., and Henry, J.-P., 1981, pH-dependence of the ATP-driven uptake of noradrenaline by bovine chromaffin-granule ghosts, Eur. J. Biochem. 116:535–539.

    Google Scholar 

  • Schmidt, W., Winkler, H., and Plattner, H., 1982, Adrenal chromaffin granules: Evidence for an ultra-structural equivalent of the proton pumping ATPase, Eur. J. Cell Biol. 27: 96–104.

    PubMed  CAS  Google Scholar 

  • Schuldiner, S., Fishkes, H., and Kanner, B. L., 1978, Role of a transmembrane pH gradient in epinephrine transport by chromaffin granule membrane vesicles, Proc. Natl. Acad. Sci. USA 75: 3713–3716.

    PubMed  CAS  Google Scholar 

  • Sen, R., and Sharp, R. R., 1980, The soluble components of chromaffin granules, a carbon-13 NMR survey, Biochim. Biophys. Acta 630: 447–458.

    PubMed  CAS  Google Scholar 

  • Serck-Hannsen, G., and Christiansen, E. N., 1973, Uptake of calcium in chromaffin granules of bovine adrenal medulla stimulated in vitro, Biochim. Biophys. Acta 307: 404–414.

    Google Scholar 

  • Silsand, T., and Flatmark, T., 1974, Purification of cytochrome b561, an integral heure protein of the adrenal chromaffin granule membrane, Biochim. Biophys. Acta 395: 257–266.

    Google Scholar 

  • Skotland, T., and Flatmark, T., 1979, On the amphiphilic and hydrophobic forms of dopamine-ß-monooxygenase in bovine adrenal medulla, J. Neurochem. 31:1861–1863.

    Google Scholar 

  • Skotland, T., and Ljones, T., 1979, Dopamine-3-hydroxylase: Structure, mechanism, and properties of the enzyme bound copper, Inorg. Perspect. Biol. Med. 2: 151–180.

    CAS  Google Scholar 

  • Slotkin, T. A., 1975a, Maturation of the adrenal medulla. III. Practical and theoretical considerations of the age-dependent alterations in kinetics of incorporation of catecholamines and non-catecholamines, Biochem. Pharmacol. 24: 89–97.

    PubMed  CAS  Google Scholar 

  • Slotkin, T. A., 1975b, Structure-activity relationships for the reserpine-like actions of derivatives of 3carboline in vitro, Life Sci. 15: 439–454.

    Google Scholar 

  • Slotkin, T. A., and Kirshner, N., 1971, Uptake, storage, and distribution of amines in bovine adrenal medullary vesicles, Mol. Pharmacol. 7: 581–592.

    PubMed  CAS  Google Scholar 

  • Smith, A. D., and Winkler, H., 1967, A simple method for the isolation of adrenal chromaffin granules on a large scale, Biochem. J. 103: 480–482.

    PubMed  CAS  Google Scholar 

  • Spiro, M. J., and Ball, E. G., 1961, Studies on the respiratory enzymes of the adrenal gland, J. Biol. Chem. 236: 225–229.

    PubMed  CAS  Google Scholar 

  • Stern, A. S., Lewis, R. V., Kimura, S., Rossier, J., Gerber, L. D., Brink, L., Stern, S., and Udenfriend, S., 1979, Isolation of the opioid heptopeptide Met-enkephalin (Arg6Phe7) from the bovine adrenal medullary granules and striatum, Proc. Natl. Acad. Sci. USA 76: 6680–6683.

    PubMed  CAS  Google Scholar 

  • Stern, A. S., Jones, B. N., Shively, J. E., Stern, S., and Udenfriend, S., 1981, Two adrenal opioid polypeptides: Proposed intermediates in the processing of proenkephalin, Proc. Natl. Acad. Sci. USA 78: 1962–1966.

    PubMed  CAS  Google Scholar 

  • Stitzel, R., 1977, The biological fate of reserpine, Pharmacol. Rev. 28: 179–205.

    Google Scholar 

  • Sutton, R., and Apps, D. K., 1981, Isolation of a DCCD binding protein from bovine chromaffin granule membranes, FEBS Leu. 130: 103–106.

    CAS  Google Scholar 

  • Taugner, G., 1971, The membrane of catecholamine storage vesicles of adrenal medulla. Catecholamine fluxes and ATPase activity, Naunyn-Schmiedeberg’s Arch. Pharmacol. 270: 392–406.

    PubMed  CAS  Google Scholar 

  • Taugner, G., 1972, The membrane of catecholamine storage vesicles of adrenal medulla. Uptake and release of noradrenaline in relation to the pH and the concentration of steric configuration of the amine present in medium, Naunyn-Schmiedeberg’s Arch. Pharmacol. 274: 299–314.

    PubMed  CAS  Google Scholar 

  • Terland, O., and Flatmark, T., 1973, NADH (NADPH) acceptor oxidoreductase activities of the bovine adrenal chromaffin granules, Biochim. Biophys. Acta 305: 206–218.

    PubMed  CAS  Google Scholar 

  • Terland, O., and Flatmark, T., 1975, Ascorbate as a natural constituent of chromaffin granules from the bovine adrenal medulla, FEBS Lett. 59: 52–56.

    PubMed  CAS  Google Scholar 

  • Terland, O., and Flatmark, T., 1980, Oxidoreductase activities of chromaffin granule ghosts isolated from the bovine adrenal medulla, Biochim. Biophys. Acta 597: 318–330.

    PubMed  CAS  Google Scholar 

  • Terland, O., Silsand, T., and Flatmark, T., 1974, Cytochrome 6561 as the single heme protein of the bovine adrenal chromaffin granule membrane, Biochim. Biophys. Acta 359: 253–256.

    PubMed  CAS  Google Scholar 

  • Terland, O., Flatmark, T., and Kryvi, H., 1979, Isolation and characterization of noradrenaline storage granules of bovine adrenal medulla, Biochim. Biophys. Acta 553: 460–468.

    PubMed  CAS  Google Scholar 

  • Tirrell, J. G., and Westhead, E. W., 1978, Ascorbate uptake and metabolism by adrenal medullary granules, in: Catecholamines: Basic and Clinical Frontiers ( E. Usdine, I. H. Kopin, and J. Barchas, eds.), Pergamon Press, New York, pp. 181–186.

    Google Scholar 

  • Tirrell, J. G., and Westhead, E., 1979, The uptake of ascorbic acid and dehydroascorbic acid by chromaffin granules of the adrenal medulla, Neuroscience 4: 181–186.

    PubMed  CAS  Google Scholar 

  • Toll, L., and Howard, B. D., 1980, Evidence that an ATPase and a protonmotive force function in the transport of acetylcholine into storage vesicles, J. Biol. Chem. 255: 1787–1789.

    PubMed  CAS  Google Scholar 

  • Trifaro, J. M., and Dworkind, J., 1970, A new and simple method for the isolation of adrenal chromaffin granules by means of an isotonic density gradient, Anal. Biochem. 34: 403–412.

    PubMed  CAS  Google Scholar 

  • Trifaro, J. M., and Poisner, A. M., 1967, The role of ATP and ATPase in the release of catecholamines from the adrenal medulla. II. ATP evoked fall in optical density of isolated chromaffin granules, Mol. Pharmacol. 3: 572–580.

    PubMed  CAS  Google Scholar 

  • Viveros, O. H., Diliberto, E. J., Hazum, E., and Chang, K. J., 1979, Opiate like materials in the adrenal medulla: Evidence for storage and secretion with catecholamines, Mol. Pharmacol. 16: 1101–1108.

    PubMed  CAS  Google Scholar 

  • Viveros, O. H., Diliberto, E. J., Hazum, E., and Chany, K. J., 1980, Enkephalin as possible adrenomedullary hormones: Storage, secretion, and regulation of synthesis, in: Advances in Biochemical Psychopharmacology, Vol. 22 ( E. Costa and M. Trabucchi, eds.), Raven Press, New York, pp. 191–204.

    Google Scholar 

  • Voyta, J. C., Slakey, L. L., and Westhead, E. W., 1978, Accessibility of lysolecithin in catecholamine secretory vesicles to acyl CoA: lysolecithin acyl transferase. Biochem. Biophys. Res. Commun. 80: 413–417.

    PubMed  CAS  Google Scholar 

  • Wallace, E. G., Krantz, M. J., and Lovenberg, W., 1973, Dopamine-3-hydroxylase: A tetrameric glycoprotein, Proc. Natl. Acad. Sci. USA 70: 2253–2255.

    PubMed  CAS  Google Scholar 

  • Weber, A., and Winkler, H., 1981, Specificity and mechanisms of nucleotide uptake by adrenal chromaffin granules, Neuroscience 6: 2269–2276.

    PubMed  CAS  Google Scholar 

  • Weber, A., Westhead, E. W., and Winkler, H., 1983, Specificity and properties of the nucleotide carrier in chromaffin granules from bovine adrenal medulla, Biochem. J. 210: 789–794.

    PubMed  CAS  Google Scholar 

  • Wilkins, J. A., and Salgonicoff, L., 1981, Participation of a transmembrane proton gradient in 5-hydrox-ytryptamine transport by platelet dense granules and dense-granule ghosts, Biochem. J. 198 (1): 113–123.

    PubMed  CAS  Google Scholar 

  • Winkler, H., 1969, Isolierung and Charakterisierung von chromaffinen Noradrenalin-Granula aus SchweineNebennierenmark, Naunyn-Schmiedebergs Arch. Pharmakol. 263: 340–357.

    CAS  Google Scholar 

  • Winkler, H., 1976, The composition of adrenal chromaffin granules: An assessment of controversial results, Neuroscience 1: 65–80.

    PubMed  CAS  Google Scholar 

  • Winkler, H., 1977, The biogenesis of adrenal chromaffin granules, Neuroscience 2: 657–683.

    PubMed  CAS  Google Scholar 

  • Winkler, H., 1982, The proteins of catecholamine-storing organelles, Scand. J. Lmmunol. 15 (Suppl. 9): 75–96.

    Google Scholar 

  • Winkler, H., and Carmichael, S. W., 1982, The Secretory Granule (E. Poisner and J. Trifaro, eds.), Elsevier Biomedical Press, Amsterdam.

    Google Scholar 

  • Winkler, H., and Westhead, E., 1980, The molecular organization of adrenal chromaffin granules, Neuroscience 5: 1803–1823.

    PubMed  CAS  Google Scholar 

  • Zaremba, S., and Hogue-Angelleti, R. A., 1981, Transmembrane nature of chromaffin granule dopamine0-monooxygenase, J. Biol. Chem. 256: 12310–12315.

    PubMed  CAS  Google Scholar 

  • Zaremba, S., and Hogue-Angelleti, R. A., 1982, NADH: (acceptor) oxidoreductase from bovine adrenal medulla chromaffin granules, Arch. Biochem. Biophys. 219: 297–305.

    PubMed  CAS  Google Scholar 

  • Zinder, O., Hoffman, P. G., Bonner, W. M., and Pollard, H. B., 1978, Comparison of chemical properties of purified plasma membranes and secretory vesicle membranes from the bovine adrenal medulla, Cell Tissue Res. 188: 153–170.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104, USA

    Sally E. Carty, Robert G. Johnson & Antonio Scarpa

Authors
  1. Sally E. Carty
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Robert G. Johnson
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Antonio Scarpa
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. State University of New York, Syracuse, New York, USA

    Anthony N. Martonosi

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Plenum Press, New York

About this chapter

Cite this chapter

Carty, S.E., Johnson, R.G., Scarpa, A. (1985). H+-Translocating ATPase and Other Membrane Enzymes Involved in the Accumulation and Storage of Biological Amines in Chromaffin Granules. In: Martonosi, A.N. (eds) The Enzymes of Biological Membranes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4601-2_13

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-4601-2_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4603-6

  • Online ISBN: 978-1-4684-4601-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation