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Kinetics of Vascular Clearance of Particles by Phagocytes

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Physiology

Abstract

There are several good reasons for studying the kinetics of vascular clearance of intravenously administered particles. The primary objectives are to identify those parameters which limit the rate of vascular clearance, show how these parameters interact, and determine at which points control of vascular clearance occurs. At present, the kinetics of phagocytosis are best studied in vivo and the descriptions of the process have been largely achieved based on in vivo measurements. In vivo, there is an adequate number of cells to ensure measurable uptake over a sustained period of time, cell-associated particles are readily separable from those in the fluid phase, measurement of removal is readily achieved, and the conditions of flow, particle availability, and media are biologically relevant. The insights gained from the study of vascular clearance with model particles are presumably relevant to the basic issues of how macrophages recognize nonself and of how things get into cells.

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  1. Department of Pathology, College of Medicine, University of Florida, Gainesville, Florida, 32610, USA

    Sigurd J. Normann

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  1. Medical College of Georgia, Augusta, Georgia, USA

    Sherwood M. Reichard

  2. Loyola University Medical Center, Maywood, Illinois, USA

    James P. Filkins

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Normann, S.J. (1984). Kinetics of Vascular Clearance of Particles by Phagocytes. In: Reichard, S.M., Filkins, J.P. (eds) Physiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4574-9_4

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