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Norepinephrine

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Handbook of Neurochemistry

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Abstract

Ramon y Cajal’s neurohistological studies demonstrated that the nervous sys tem consists of an interlacing network of nerve cells with specialized contact areas between their processes. Although the specialized area of contact, the synapse, was recognized as being the site of transmission between nerve cells, nothing was known of the mechanism of this transmission. Scott1 in 1905 was the first to put forward a general theory of chemical transmission. He emphasized that the process of conduction to the synapse and the stimulation of the next cell were entirely different properties of the neuron. On the basis of histological resemblances between gland cells and nerve cells, he suggested that the latter are also secretory and that the arrival of the impulse at the synapse causes the discharge of a chemical substance. Furthermore, he wrote

Since the discharge means the using up of formed material, it must be an exhaustible process, and the process of complete recovery at the synapse must depend on the integrity of the connection of the synapse with the nucleus and cell body which are the original seats of formation of the material involved in the activity.

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References

  1. Scott, F. H., 1905, Brain 28:506–526.

    Google Scholar 

  2. Langley, J. N., 1901, J. Physiol. (Lond.) 27:237–256.

    CAS  Google Scholar 

  3. Elliott, T. R., 1905, J. Physiol. (Lond.) 32:401–467.

    Google Scholar 

  4. Katz, B., 1969, The Release of Neural Transmitter Substances. The Sherrington Lectures X , Liverpool University Press, Liverpool.

    Google Scholar 

  5. Eränkö, O., 1955, Acta Endocrinol. (Kbh.) 18:174–179.

    Google Scholar 

  6. Falck, B., Hillarp, N. A., Thieme, G., and Torp, A., 1962, J. Histochem. Cytochem. 10:348–354.

    CAS  Google Scholar 

  7. Jonsson, G., 1969, J. Histochem. Cytochem. 17:714–723.

    PubMed  CAS  Google Scholar 

  8. von Euler, V. S., and Hillarp, N.-A., 1956, Nature 177:44–45.

    Google Scholar 

  9. Roth, R. H., Stjarne, L., Bloom, F. E., and Giarman, N. J., 1968, J. Pharmacol. Exp. Ther. 162:185–194.

    Google Scholar 

  10. Tranzer, J. P., 1972, Nature (New Biol.) 237:57–58.

    CAS  Google Scholar 

  11. Descarries, L., and Droz, B., 1970, J. Cell. Biol. 44:385–399.

    PubMed  CAS  Google Scholar 

  12. Lagercrantz, H., Klein, R. L., and Stjarne, L., 1970, Life Sci. 9:639–650.

    CAS  Google Scholar 

  13. Bisby, M. A., 1971, D.Phil. Thesis, Oxford.

    Google Scholar 

  14. Lagercrantz, H., 1976, Neuroscience 1:81–92.

    PubMed  CAS  Google Scholar 

  15. Tranzer, J. P., and Richards, J. G., 1976, J. Histochem. Cytochem. 24:1178–1193.

    PubMed  CAS  Google Scholar 

  16. Lagercrantz, H., and Thureson-Klein, A., 1975, Histochemistry 43:173–183.

    PubMed  CAS  Google Scholar 

  17. Klein, R. L., and Thureson-Klein, A., 1974, Fed. Proc. 33:2195–2206.

    CAS  Google Scholar 

  18. Klein, R. L., Kirksey, D. F., Rush, R. A., and Goldstein, M., 1977, J. Neurochem. 28:81–86.

    PubMed  CAS  Google Scholar 

  19. Kirksey, D. F., Klein, R. L., Baggett, J. McC., and Gasparis, M. S., 1978, Neuroscience 2:621–634.

    Google Scholar 

  20. Wilson, S. P., Klein, R. L., Chang, K.-J., Gasparis, M. S., Viveros, O. H., and Yang, N. H., 1980, Nature 288:707–709.

    PubMed  CAS  Google Scholar 

  21. Bisby, M. A., and Fillenz, M., 1971, J. Physiol. (Lond.) 215:163–179.

    CAS  Google Scholar 

  22. Thureson-Klein, A., Klein, R. L., and Stjarne, L., 1976, Neurosci. Abstr. 2.

    Google Scholar 

  23. Fillenz, M., 1971, Phil. Trans. R. Soc. [Biol.] 261:319–323.

    CAS  Google Scholar 

  24. Thureson-Klein, A., Stjarne, L., and Brundin, J., 1976, Neuroscience 1:333–337.

    PubMed  CAS  Google Scholar 

  25. Thureson-Klein, A., Stjarne, L., and Brundin, J., 1976, 34th Ann. Proc. Electron Microscopy Soc. Amer. (G. W. Bailey, ed.), Miami Beach, Florida, pp. 108–109.

    Google Scholar 

  26. Bisby, M. A., Cripps, H., and Dearneley, D. P., 1971, J. Physiol. (Lond.) 214:13–14P.

    Google Scholar 

  27. Nelson, D. L., and Molinoff, P. B., 1976, J. Pharmacol. Exp. Ther. 198:112–113.

    PubMed  CAS  Google Scholar 

  28. Basbaum, C. B., and Heuser, J. E., 1979, J. Cell Biol. 80:310–325.

    PubMed  CAS  Google Scholar 

  29. Pollard, R. M., Fillenz, M., and Kelly, P., 1982, Neuroscience 7:1623–1629.

    PubMed  CAS  Google Scholar 

  30. Kapeller, K., and Mayor, D., 1967, Proc. R. Soc. Lond. [Biol.] 167:282–292.

    CAS  Google Scholar 

  31. De Potter, N. P., Chubb, I. W., and De Schaepdryver, A. F., 1972, Arch. Int. Pharmacodyn. Ther. [Suppl.] 196:258–287.

    Google Scholar 

  32. Lagercrantz, H., Kirksey, D. F., and Klein, R. L., 1974, J. Neurochem. 23:769–773.

    PubMed  CAS  Google Scholar 

  33. Yen, S. S., Klein, R. L., Chen Yen, S. H., and Thureson-Klein, A., 1976,J. Neurobiol. 7:11–22.

    PubMed  CAS  Google Scholar 

  34. Klein, R. L., Thureson-Klein, A., Chen Yen, S. H., Baggett, J. McC., Gasparis, M. S., and Kirksey, D. F., 1979, J. Neurogiol. 10:291–307.

    CAS  Google Scholar 

  35. Yen, S. S., Klein, R. L., Chen Yen, S. H., 1973, J. Neurocytol. 2:1–12.

    PubMed  CAS  Google Scholar 

  36. Lagercrantz, H., Fried, G., and Dahlin, J., 1975, Acta Physiol. Scand. 94:136–138.

    PubMed  CAS  Google Scholar 

  37. Stjarne, L., 1972, Handbook of Experimental Pharmacology ,Volume 33 (H. Blaschko and E. Muscholl, eds.), pp. 231–261, Springer-Verlag, Berlin, Heidelberg, New York.

    Google Scholar 

  38. von Euler, V. S., 1980, Release and Uptake Functions in Adrenergic Nerve Granules. The S herrinton Lectures XV ,Liverpool University Press, Liverpool.

    Google Scholar 

  39. Klein, R. L., and Lagercrantz, H., 1971, Acta Physiol. Scand. 83:179–190.

    PubMed  CAS  Google Scholar 

  40. Richards, J. G., and Da Prada, M., 1980, Histochemistry and Cell Biology of Autonomie Neurons, SIF Cells and Paraneurons (O. Eranko, S. Soinila and H. Paivarinta, eds.), Raven Press, New York, pp. 269–278.

    Google Scholar 

  41. Fried, G., Lagercrantz, H., and Hökfelt, T., 1978, Neuroscience 3:1271–1291.

    PubMed  CAS  Google Scholar 

  42. Fried, G., 1980, Acta Physiol Scand. Suppl. 493:1–28.

    PubMed  CAS  Google Scholar 

  43. von Euler, U. S., 1970, Bayer Symposium II (H. J. Schumann and G. Kroneberg, eds.), Springer-Verlag, Berlin, Heidelberg, New York, pp. 144–159.

    Google Scholar 

  44. Fried, G., 1981, Acta Physiol. Scand. 112:41–46.

    PubMed  CAS  Google Scholar 

  45. Bareis, D. L., and Slotkin, T. A., 1979, J. Neurochem. 32:345–351.

    PubMed  CAS  Google Scholar 

  46. Fillenz, M., Howe, P. R. C., and West, D. P., 1976, J. Neurosci. 1:113–116.

    CAS  Google Scholar 

  47. West, D. P., and Fillenz, M., 1980, J. Neurochem. 35:1323–1328.

    PubMed  CAS  Google Scholar 

  48. Fillenz, M., and Stanford, S. C., 1981, Br. J. Pharmacol. 73:401–404.

    PubMed  CAS  Google Scholar 

  49. Gomez, J., and Fillenz, M., 1982, Neurochem. Int. 4:135–141.

    PubMed  CAS  Google Scholar 

  50. Fried, G., Thureson-Klein, A., and Lagercrantz, H., 1981, Neuroscience 6:787–800.

    PubMed  CAS  Google Scholar 

  51. Fillenz, M., and Pollard, R. M., 1976, Brain Res. 109:443–454.

    PubMed  CAS  Google Scholar 

  52. Chubb, I. W., De Potter, W. P., and De Schaepdryver, A. F., 1970, Nature 228:1203–1204.

    PubMed  CAS  Google Scholar 

  53. De Potter, W. P., and Chubb, I. W., 1977, Neuroscience 2:167–174.

    PubMed  Google Scholar 

  54. Nelson, D. L., and Molinoff, P. B., 1976, J. Pharmacol. Exp. Ther. 196:346–359.

    PubMed  CAS  Google Scholar 

  55. De Potter, W. P., and De Smet, F. H., 1980, Experientia 36:1282–1285.

    PubMed  Google Scholar 

  56. Rush, R. A., Millar, T. J., Chubb, I. W., and Geffen, L. B., 1978, Catecholamines: Basic and Clinical Frontiers (E. Usdin, I. Kopin, and J. Barchas eds.), Pergamon Press, London, pp. 331–333.

    Google Scholar 

  57. Fillenz, M., and Howe, P. R. C., 1975, J. Neurochem. 24:683–688.

    PubMed  CAS  Google Scholar 

  58. Coté, M. G., Palaic, D., and Panisset, J. C., 1970, Rev. Can. Biol. 29:111–114.

    PubMed  Google Scholar 

  59. Hamilton, R. C., and Robinson, P. M., 1973, J. Neurocytol. 2:465–480.

    PubMed  CAS  Google Scholar 

  60. Heuser, J., and Reese, T., 1973, J. Cell Biol. 57:315–344.

    PubMed  CAS  Google Scholar 

  61. Fillenz, M., and West, D. P., 1976, Neurosci. Lett. 2:285–287.

    PubMed  CAS  Google Scholar 

  62. Tomlinson, D., 1975, J. Physiol. (Lond.) 245:727–735.

    CAS  Google Scholar 

  63. Holtzmann, E., 1977, Neuroscience 2:327–356.

    Google Scholar 

  64. Fillenz, M., 1979, The Release of Catecholamines from Adrenergic Neurons (D. M. Paton, ed.), Pergamon Press, London, pp. 17–38.

    Google Scholar 

  65. Benedict, C. R., Fillenz, M., and Stanford, S. C., 1979, Br. J. Pharmacol. 66:521–524.

    PubMed  CAS  Google Scholar 

  66. Fillenz, M., Stanford, S. C., and Benedict, C. R., 1978, Catecholamines: Basic and Clinical Frontiers (E. Usdin, I. Kopin, and J. Barchas, eds.), Pergamon Press, London, pp. 936–938.

    Google Scholar 

  67. Brimijoin, S., 1974, J. Neurochem. 22:347–353.

    PubMed  CAS  Google Scholar 

  68. Stjarne, L., and Lischajko, F., 1966, Br. J. Pharmacol. 27:398–404.

    CAS  Google Scholar 

  69. Pickel, V. M., Joh, T. H., and Reis, D. J., 1976, J. Histochem. Cytochem. 24:792–806.

    PubMed  CAS  Google Scholar 

  70. Laduron, P., and Belpaire, F., 1968, Nature 217:1155–1156.

    PubMed  CAS  Google Scholar 

  71. Coyle, J. T., and Wooten, G. F., 1972, Brain Res. 44:701–705.

    PubMed  CAS  Google Scholar 

  72. Oesch, F., Otten, V., and Thoenen, H., 1973, J. Neurochem. 20:1691–1706.

    PubMed  CAS  Google Scholar 

  73. Fillenz, M., Gagnon, C., Stoeckel, K., and Thoenen, H., 1976, Brain Res. 114:293–304.

    PubMed  CAS  Google Scholar 

  74. Brimijoin, S., 1975, J. Neurobiol. 6:379–394.

    PubMed  CAS  Google Scholar 

  75. Brimijoin, S., and Heiland, L., 1976, Brain Res. 102:217–228.

    PubMed  CAS  Google Scholar 

  76. Nagatsu, I., Kondo, Y., Kato, T., and Nagatsu, T., 1976, Brain Res. 116:277–285.

    PubMed  CAS  Google Scholar 

  77. Livett, B. G., Geffen, L. B., and Austin, L., 1968, J. Neurochem. 15:931–939.

    PubMed  CAS  Google Scholar 

  78. De Potter, W. P., and Chubb, I. W., 1971, Biochem. J. ,125:375–376.

    PubMed  Google Scholar 

  79. Thoenen, H., Kettler, R., Burkard, W., and Saner, A., 1971, Naunyn Schmiedebergs Arch. Pharmakol. 270:146–160.

    PubMed  CAS  Google Scholar 

  80. Thoenen, H., 1972, Biochem. Soc. Symp. 36:3–15.

    PubMed  CAS  Google Scholar 

  81. Raine, A. E. G., and Chubb, I. W., 1977, Nature 267:265–267.

    PubMed  CAS  Google Scholar 

  82. Otten, U., and Thoenen, H., 1976, Naunyn Schmiedebergs Arch. Pharmakol 292:153–159.

    CAS  Google Scholar 

  83. Reis, D. J., Joh, T. H., and Ross, R. A., 1975, J. Pharmacol. Exp. Ther. 193:775–784.

    PubMed  CAS  Google Scholar 

  84. Joh, T. H., Ross, R. A., and Reis, D. J., 1976, Fed. Proc. 35:485.

    Google Scholar 

  85. Thoenen, H., and Oesch, F., 1973, New Concepts in Neurotransmitter Regulation (A. J. Mandell, ed.), Plenum Press, New York, pp. 33–51.

    Google Scholar 

  86. Reis, D. J., Ross, R. A., Pickel, V. M., and Joh, T. H., 1977, Neurotransmitter Function: Basic and Clinical Aspects (W. S. Fields, ed.), Symposia Specialists, Chicago, pp. 143–161.

    Google Scholar 

  87. Fredholm, B. B., Fried, G., and Hedqvist, P., 1981, Eur. J. Pharmacol. 79:233–243.

    Google Scholar 

  88. Smith, A. D., De Potter, W. P., Moerman, E. J., and De Schaepdryver, A. F., 1970, Tissue Cell 2:547–568.

    PubMed  CAS  Google Scholar 

  89. Weinshilboum, R. M., Thoa, N. B., Johnson, D. G., Kopin, I. J., and Axelrod, J., 1971, Science 174:1349–1351.

    PubMed  CAS  Google Scholar 

  90. Fillenz, M., and West, D. P., 1974, J. Neurochem. 23:411–416.

    PubMed  CAS  Google Scholar 

  91. Brodde, O.-E., Hubermann, K., and Schumann, H. T., 1976, J. Neurochem. 27:433–438.

    PubMed  CAS  Google Scholar 

  92. Lees, G. J., Geffen, L. B., and Rush, R. A., 1981, Neurosci. Lett. 22:115–118.

    PubMed  CAS  Google Scholar 

  93. Geffen, L. B., Hunter, C., and Rush, R. A., 1969, J. Neurochem. 16:469–474.

    PubMed  CAS  Google Scholar 

  94. Font, C., Araneda, S., Pujol, J. F., Jouvet, M., and Bobillier, P., 1980, Neurosci. Lett. [Suppl.] 5:SI92.

    Google Scholar 

  95. Weinshilboum, R., and Axelrod, J., 1971, Circ. Res. 28:307–315.

    PubMed  CAS  Google Scholar 

  96. De Potter, W. P., Chank, C. P-H., De Smet, F., and De Schaepdryver, A. F., 1976, Neu roscience 1:523–529.

    Google Scholar 

  97. Greenfield, S. A., and Smith, A. D., 1979, Brain Res. 177:445–459.

    PubMed  CAS  Google Scholar 

  98. Blakeìeytà. G. H., and Cunnane, T. C., 1979, J. Physiol. (Lond.) 296:85–96.

    Google Scholar 

  99. Raiteri, M., del Carmine, R., Bertollini, A., and Levi, G., 1977, Mol. Pharmacol. 13:746–758.

    PubMed  CAS  Google Scholar 

  100. West, D. P., and Fillenz, M., 1981, J. Neurochem. 37:1052–1053.

    PubMed  CAS  Google Scholar 

  101. De Potter, W. P., Chubb, I. W., Put, A., and De Schaepdryver, A. F., 1971, Arch. Int. Pharmacodyn. Ther. 193:191–197.

    PubMed  Google Scholar 

  102. Langer, S. Z., 1979, The Release of Catecholamines from Adrenergic Neurons (D. M. Paton, ed.), Pergamon Press, London, pp. 59–85.

    Google Scholar 

  103. Lokhandwala, M. F., 1979, Life Sci. 24:1823–1832.

    PubMed  CAS  Google Scholar 

  104. Arbilla, S., and Langer, S. Z., 1979, Naunyn Schmiedebergs Arch. Pharmacol. 306:161–168.

    PubMed  CAS  Google Scholar 

  105. Bowery, N. G., Hill, D. R., Hudson, A. L., Doble, A., Middlemiss, D. N., Shaw, J., and Turnbull, M., 1980, Nature 283:92–94.

    PubMed  CAS  Google Scholar 

  106. De Langen, C. D. J., and Mulder, A. H., 1980, Brain Res. 185:399–408.

    PubMed  Google Scholar 

  107. Hedqvist, P., 1976, Br. J. Pharmacol. 58:599–603.

    PubMed  CAS  Google Scholar 

  108. Gothert, M., and Wehking, E., 1980, Experientia 36:239–240.

    PubMed  CAS  Google Scholar 

  109. Reisine, T., 1981, Neuroscience 6:1471–1502.

    PubMed  CAS  Google Scholar 

  110. Stanford, S. C., and Nutt, D., 1982, Neuroscience 7:1753–1757.

    PubMed  CAS  Google Scholar 

  111. Salzman, P. M., and Roth, R. H., 1980, J. Pharmacol. Exp. Ther. 212:64–73.

    PubMed  CAS  Google Scholar 

  112. Lewander, T., Joh, T. H., and Reis, D. J., 1977, J. Pharmacol. Exp. Ther. 200:523–534.

    PubMed  CAS  Google Scholar 

  113. McRae Degueurce, A., 1980, Ph.D. Thesis, Lyon.

    Google Scholar 

  114. Dairman, W., and Udenfriend, S., 1970, Mol. Pharmacol. 6:350–356.

    PubMed  CAS  Google Scholar 

  115. Boarder, M. R., and Fillenz, M., 1979, Biochem. Pharmacol. 28:1675–1677.

    PubMed  CAS  Google Scholar 

  116. Abou-Donia, M. M., and Viveros, O. H., 1981, Proc. Nacl. Acad. Sci. U.S.A. 78:2703–2706.

    CAS  Google Scholar 

  117. Acheson, A. L., Zigmond, M. J., and Stricker, E. M., 1980, Science 207:537–540.

    PubMed  CAS  Google Scholar 

  118. Zigmond, M. J., Acheson, A. L., Chiodo, L. A., and Strieker, E. M., 1981, Neurosci. Abstr. 7:149.

    Google Scholar 

  119. Costa, M., and Eränkö, O., 1974, Histochem. J. 6:35–53.

    PubMed  CAS  Google Scholar 

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  1. University Laboratory of Physiology, Oxford, Oxford, OX1 3PT, England

    Marianne Fillenz

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  1. Marianne Fillenz
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  1. Center for Neurochemistry, Wards Island, New York, USA

    Abel Lajtha

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Fillenz, M. (1984). Norepinephrine. In: Lajtha, A. (eds) Handbook of Neurochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4568-8_4

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