Abstract
The membrane receptor is a site at which specific chemicals can regulate cell ular function; in turn, cells can regulate their sensitivity to many chemicals to compensate for persistent changes in agonist supply. The terms up- and down-regulation are used to describe shifts in receptor responsivity to drugs or to endogenous transmitters. Chronic antagonist administration, for example, can lead to a proliferation of receptor sites, a change viewed as an attempt by the cell to compensate for the loss of agonist resulting from the blockade by antagonist. In similar fashion, down-regulation can take place with chronic agonist oversupply. Thus, the receptor can act as both a regulated and regulatory unit. In this chapter an attempt is made to identify specific neuronal receptors that are acted on and ultimately altered by neuroleptics, antidepressants, and anxiolytic benzodiazepines and to discuss the application of receptor sensitivity modification (RSM) as a new approach to treatment of disorders that are responsive to alterations of CNS monoaminergic activity.
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Seeman, P., 1980, Pharmacol. Rev. 32:229–313.
Burt, D. R., Creese, I., and Snyder, S. H., 1977, Science 196:326–328.
Clow, A., Jenner, P., Marsden, C. D., Murugaiah, K., and Theodorou, A., 1980, Proc. Br. Psychiatr. Soc. 242P.
Friedhoff, A. J., Bonnet, K., and Rosengarten, H., 1977, Res. Commun. Chem. Pathol. Pharmacol. 16:411–423.
Hyttel, J., 1978, Life Sci. 23:551–556.
Faustman, W., Fowler, S., and Walker, C., 1981, Eur. J. Pharmacol. 70:65–70.
Kobayashi, R. M., Fields, J. Z., Hruska, R. E., Beaumont, K., and Yamamura, H. I., 1977, Animal Models in Psychiatry and Neurology (I. Hanin and E. Usdin, eds.), Pergamon Press, New York, pp. 405–409.
Bacopoulos, N. G., 1981, Biochem. Pharmacol. 30:2037–2040.
Leysen, J. E., and Gommeren, W., 1981, J. Neurochem. 36:201–219.
Blaschke, E., and Hertting, G., 1971, Biochem. Pharmacol. 20:1363–1370.
Kayaalp, S. O., Rubenstein, J. S., and Neff, N. H., 1981, Neuropharmacology 20:409–410.
Zahniser, N. R., and Molinoff, P. B., 1978, Nature 275:453–455.
Scatchard, G., 1949, Ann. N.Y. Acad. Sci. 53:660–672.
Feldman, H. A., 1972, Anal. Biochem. 48:317–338.
Williams, L. T., and Lefkowitz, R. J., 1978, Receptor Binding Studies in Adrenergic Phar macology ,Raven Press, New York.
Yamamura, H. I., Enna, S. J., and Kuhar, M. J., 1978, Neurotransmitter Receptor Binding ,Raven Press, New York.
Sibley, D. R., and Creese, I., 1980, Eur. J. Pharmacol. 65:131–133.
Wehr, T. A., Wirz-Justice, A., Goodwin, F. K., Duncan, W., and Gillin, J. C., 1979, Science 206:710–713.
Cools, A. R., 1978, Life Sci. 23:2475–2484.
Naber, D., Wirz-Justice, A., Kafka, M. S., and Wehr, T. A., 1980, Psychopharmacology 68:1–5.
Naber, D., Wirz-Justice, A., Kafka, M. S., Tobler, I., and Borbely, A. A., 1981, Biol. Psychiatry 16:831–835.
Wirz-Justice, A., Kafka, M. S., Naber, D., and Wehr, T. A., 1980, Life Sci. 27:341–347.
Kafka, M. S., Wirz-Justice, A., Naber, D., and Wehr, T. A., 1981, Neuropharmacology 20:421–425.
Kafka, M. S., Wirz-Justice, A., and Naber, D., 1981, Brain Res. 207:409–419.
Codd, E. E., and Byrne, W. L., 1981, Life Sci. 28:2577–2583.
Schwartz, J.-C., Baudry, M., Martres, M.-P., Costentin, J., and Protais, P., 1978, Life Sci. 23:1785–1790.
Christensen, A. V., Fjalland, B., and Moller-Nielsen, I., 1976, Psychopharmacology 48:1–6.
Chiodo, L. A., and Antelman, S. M., 1980, Science 210:799–801.
Muller, P., and Seeman, P., 1978, Psychopharmacology 60:1–11.
Baldessarini, R. J., and Tarsy, D., 1978, Psychopharmacology: A Generation of Progress (M. A. Lipton, A. DiMascio, and K. F. Killam, eds.), Raven Press, New York, pp. 993–1004.
Waddington, J. L., and Gamble, S. J., 1980, Eur. J. Pharmacol. 68:387–388.
Waddington, J. L., and Gamble, S. J., 1981, Lancet 1:1375.
Weiss, B., and Santelli, S., 1978, Science 200:799–801.
Weiss, B., Santelli, S., and Lusink, G., 1977, Psychopharmacologia 53:289.
Clow, A., Theodorou, A., Jenner, P., and Marsden, C. D., 1980, Eur. J. Pharmacol. 63:135–144.
Clow, A., Jenner, P., Theodorou, A., and Marsden, C. D., 1979, Nature 278:59–61.
Clow, A., Theodorou, A., Jenner, P., and Marsden, C. D., 1980, Eur. J. Pharmacol. 63:145–157.
Theodorou, A., Gommeren, W., Clow, A., Leysen, J., Jenner, P., and Marsden, C. D., 1981, Life Sci. 28:1621–1627.
Waddington, J. L., and Gamble, S. J., 1980, Psychopharmacology 71:75–77.
Waddington, J. L., Gamble, S. J., and Bourne, R. C., 1981, Eur. J. Pharmacol. 69:511–513.
Westerlink, B. H. C., and Horn, A. S., 1979, Eur. J. Pharmacol. 58:39–48.
Dawbarn, D., Long, S. K., and Pycock, C. J., 1980, Proc. Br. Psychiatr. Soc. 240P.
Kebabian, J. W., Chen, T. C., and Cote, T. E., 1979, Comm. Psychopharmacol. 3:421–428.
Gamble, S. J., and Waddington, J. L., 1980, Proc. Br. Psychiatr. Soc. 240P.
Dyer, R. G., Murugaiah, K., Theodorou, A., Clow, A., Jenner, P., and Marsden, C. D., mi, Life Sci. 28:167–174.
Owen, F., Cross, A. J., Waddington, J. L., Poulter, M., Gamble, S. J. and Crow, T. J., 1980, Life Sci. 26:55–59.
Cross, A. J., and Waddington, J. L., 1981, Eur. J. Pharmacol. 71:327–332.
Schwarcz, R., Creese, I., Coyle, J. T., and Snyder, S. H., 1978, Nature 271:766–768.
Euvrard, C., Premont, J., Oberlander, C., Boissier, J. R., and Bockaert, J., 1979, Naunyn Schmiedebergs Arch. Pharmacol. 309:241–245.
Marchais, D., and Bockaert, J., 1980, Biochem. Pharmacol. 29:1331–1336.
Stoof, J. C. and Kebabian, J. W., 1981, Nature 294:366–368.
Tsuruta, K., Frey, E. A., Grewe, C. W., Cote, T. E., Eskay, R. L., and Kebabian, J. W., 1981, Nature 292:463–465.
Pert, A., Rosenblatt, J. E., Sivit, C., Pert, C. B., Bunney, W. E. Jr., 1978, Science 201:171–173.
Gallager, D. W., Pert, A., and Bunney, W. E. Jr., 1978, Nature 273:309–312.
Meiler, E., and Friedman, E., 1981, Eur. J. Pharmacol. 76:25–29.
Staunton, D. A., Magistretti, P. J., Deyo, S. N., Shoemaker, W. J., and Bloom, F. E., 1981, Soc. Neurosci. Abstr. 7:163.
Ezrin-Waters, C., and Seeman, P., 1978, Life Sci. 22:1027–1032.
Tolis, C., Hickey, J., and Guyda, H., 1975, J. Clin. Endocrinol. Metab. 41:797.
Clemens, J. A., and Sawyer, B. D., 1974, Endocrine Res. Commun. 1:373.
Rossier, J., French, E., Rivier, C., Shibasaki, T., Guillemin, R., and Blood, F. E., 1980, Proc. Natl. Acad. Sci. U.S.A. 77:666–669.
Login, I. S., and MacLeod, R. M., 1979, Eur. J. Pharmacol. 60:253–255.
Belluzzi, J., and Stein, L., 1977, Nature 266:556–558.
Hong, J. S., Yang, H.-Y. T., Fratta, W., and Costa, E., 1978, J. Pharmacol. Exp. Ther. 205:141–147.
Moroni, F., Cheney, D. L., and Costa, E., 1977, Nature 267:267.
Risch, S. C., Cohen, R. M., Janowsky, D. S., Kalin, N. H., and Murphy, D. I., 1980, Science 209:1545–1546.
Hoffman, P. L., and Tabakoff, B., 1977, Nature 268:551–553.
Creese, I., and Sibley, D. R., 1981, Annu. Rev. Pharmacol. Toxicol. 21:357–391.
Puri, S. K., Spaulding, T. C., and Montione, C. R., 1978, Life Sci. 23:637–642.
Baume, S., Patey, G., Marcois, H., Protais, P., Costentin, J., and Schwartz, J.-C., 1979, Life Sci. 24:2333–2342.
Hruska, R. E., and Silbergeld, E. K., 1980, Eur. J. Pharmacol. 61:397–400.
Lozovsky, D., Sailer, C. F., and Kopin, I. J., 1981, Science 214:1031–1033.
Taylor, D. L., Ho, B. T., and Fagan, J. D., 1979, Commun. Psychopharmacol. 3:137–142.
Quik, M., and Iversen, L. L., 1979, Naunyn Schmiedebergs Arch. Pharmacol. 304:141–145.
Howlett, D. R., and Nahorski, S. R., 1979, Brain Res. 161:173–178.
Robertson, H. A., 1979, Soc. Neurosci. Abstr. 5:570.
Chiu, S., Paulose, C. S., and Mishra, R. K., 1981, Science 214:1261–1262.
Ritzmann, R. F., Walter, R., Bhargava, H. N., and Flexner, L. B., 1979, Proc. Natl. Acad. Sci. U.S.A. 76:5997–5998.
List, S., and Seeman, P., 1979, Life Sci. 24:1447–1452.
Vetulani, J., and Sulser, F., 1975, Nature 257:495–497.
Wolfe, B., Harden, T., Sporn, I., and Molinoff, P. B., 1978, J. Pharmacol. Exp. Ther. 207:446–457.
Mishra, R., Janowsky, A., and Sulser, F., 1979, Eur. J. Pharmacol. 60:379–382.
Baudry, M., Martres, M. P., and Schwartz, J.-C., 1976, Brain Res. 116:111–124.
Schmidt, M. J., and Thornberry, J. F., 1977, Arch. Int. Pharmacodyn. Ther. 229:42–51.
Leonard, B. E., 1978, Br. J. Pharmacol. 5:115–125.
Zis, A. P., and Goodwin, A. P., 1979, Arch. Gen. Psychiatry 36:1097.
Svensson, T., and Usdin, T., 1979, Catecholamine: Basic and Clinical Frontiers (E. Usdin, I. Kopir, and J. Barchas, eds.), Pergamon Press, New York, pp. 672–674.
Reisine, T. D., U’Prichard, D. C., Wiech, N., Ursillo, R., and Yamamura, H. I., 1980, Brain Res. 188:587–592.
Crews, F. T., and Smith, C. B., 1978, Science 202:322–324.
Reisine, T., 1981, Neuroscience 6:1471–1502.
Charney, D. S., Menkes, D. B., and Heninger, G. R., 1981, Arch. Gen. Psychiatry 38:1160–1180.
Mann, E., and Enna, S. J., 1980, Soc. Neurosci. Abstr. 6:800.
Tang, S. W., Seeman, P., and Kwan, S., 1980, Soc. Neurosci. Abstr. 6:861.
Blackshear, M. A., Steranke, R., and Sanders-Bush, E., 1980, Soc. Neurosci. Abstr. 6:860.
Bertilsson, L., Asberg, M., and Thoren, P., 1976, Eur. J. Clin. Pharmacol. 21:194–200.
Post, R. M., and Goodwin, F. K., 1974, Arch. Gen. Psychiatry 30:234–239.
Bowers, M. B., 1974, Clin. Pharmacol. Ther. 15:167–170.
Abrams, R., Essman, W. B., and Taylor, N. A., 1970, Biol. Psychiatry 11:85–90.
Kellar, K. J., Cascio, C. S., Butler, J. A., and Kurtzke, R. N., 1981, Eur. J. Pharmacol. 69:515–518.
Langer, S. Z., Moret, C., Raisman, R., Dubocovich, M. L., and Briley, M., 1980, Science 210:1133–1135.
Raisman, R., Briley, M., and Langer, S. Z., 1979, Eur. J. Pharmacol. 61:373–380.
Briley, M., Langer, S. Z., Raisman, R., Sechter, D., and Zarijian, E., 1980, Science 209:303–304.
Asarch, K. B., Shih, J. C., and Kulcsar, A., 1981, Soc. Neurosci. Abstr. 7:712.
Stanley, M., Virgilio, J., and Gershon, S., 1982, Science 216:1337–1339.
Dunbrille-Ross, A., and Tang, S. W., 1981, Soc. Neurosci. Abstr. 7:8.
Crews, F. T., Paul, S. M., and Goodwin, F. K., 1981, Nature 290:787–789.
Ursillo, R., Wiech, N., Reisine, T., and Yamamura, H. I., 1980, Psychopharmacology and Biochemistry of Neurotransmitter Receptors (H. I. Yamamura, R. W. Olson, and E. Usdin, eds.), Elsevier, Amsterdam, p. 189.
Schweitzer, J. W., Schwartz, R., and Friedhoff, A. J., 1979, J. Neurochem. 33:377–379.
Sarai, K., Frazer, A., Brunswick, D., and Mendels, J., 1978, Biochem. Pharmacol. 27:2179–2181.
Duman, R., Slopis, J., Kendall, D., and Enna, S. J., 1981, Soc. Neurosci. Abstr. 7:104.
Reinhard, J. F., and Roth, R. H., 1981, Soc. Neurosci. Abstr. 7:151.
Mobley, P. L., and Sulser, F., 1980, Nature 286:608–609.
Roberts, D. C. S., and Bloom, F. E., 1981, Eur. J. Pharmacol. 74:37–41.
Stone, E. A., 1979, Res. Commun. Psychol. Psychiatry Behav. 4:241–255.
Taylor, D. P., Allen, L. E., Ashworth, E. M., Becker, J. A., Hyslop, D. K., and Riblet, L. A., 1981, Neuropharmacology 20:513–516.
Johnson, R. W., Reisine, T., Spotnitz, S., Wiech, N., Ursillo, R., and Yamamura, H. I., 1980, Eur. J. Pharmacol. 67:123–127.
Basmann, H. B., 1978, FEBS. Lett. 87:199–202.
Mackerer, C., 1978, J. Pharmacol. Exp. Ther. 206:405–411.
Mohler, H., and Okada, T., 1978, Life Science 20:2101–2110.
Mohler, H., and Okada, T., 1977, Science 198:849–851.
Nielson, M., Braestrup, C., and Squires, R. F., 1978, Brain Res. 141:342–346.
Speth, R. C., and Wester, H., 1978, Life Sci. 22:859.
Speth, R. C., Wastek, C. J., and Yamamura, H. I., 1979, Life Sci. 24:351–358.
Lippa, A. S., Sano, M. C., Coupet, J., Kiepner, C. A., and Beer, B., 1978, Life Sci. 23:2213–2218.
Mallorga, P., Hamburg, M., Tallman, J. F., and Gallager, D. W., 1980, Neuropharmacology 19:405–408.
Thomas, J., Yousufi, M., and Tallman, J., 1979, Soc. Neurosci. Abstr. 5:2269.
Gavish, M., and Snyder, S. H., 1980, Life Sci. 26:579–582.
Sieghart, W., and Karobath, M., 1980, Nature 286:285–287.
Squires, R., Benson, D. I., Braestrup, C., Coupet, J., and Kiepner, C. A., 1979, Pharm. Biochem. Behav. 10:825–839.
Lippa, A. S., Critchett, D. J., Sano, M. C., Kiepner, C. A., Greenblatt, E. N., Coupet, J., and Beer, B., 1979, Pharmacol. Biochem. Behav. 10:831–843.
Skolnick, P., Marangos, P., Syapin, P., Goodwin, F., and Paul, S., 1979, Pharmacol. Biochem. Behav. 10:815–823.
Meyerson, L. R., Sano, M. C., Critchett, D. J., Beer, B., and Lippa, A. S., 1981, Eur. J. Pharmacol. 71:147–150.
Biggio, G., Corda, M. G., and Gessa, G. L., 1981, Brain Res. 220:344–349.
Lloyd, K. G., Shemen, L., and Hornykiewicz, O., 1977, Brain Res. 127:269–275.
Rinne, U. K., Koskinen, V., Laaksonen, H., Lonnberg, P., and Sonninen, V., 1978, Life Sci. 22:2225–2228.
Lloyd, K. G., Dreksler, S., and Bird, E. D., 1977, Life Sci. 21:747–754.
Olsen, R. W., Van Ness, P. C., Napias, C., Bergman, M., and Tourtellette, W. W., 1980, Adv. Biochem. Psychopharmacol. 21:451–460.
Enna, S. J., Bennett, J. P., Bylund, D. B., Snyder, S. H., Bird, E. D., and Iversen, L. L., 1976, Brain Res. 116:531–537.
Waddington, J. L., Cross, A. J., 1980, Brain Res. Bull. 5(Suppl. 2):825–828.
Davis, L. G., and Cohen, R. K., 1980, Biochem. Biophys. Res. Commun. 92:141–148.
Marangos, P. J., Paul, S. M., Goodwin, F. S., Syapin, P., and Skolnick, P., 1979, Life Sci. 24:851–858.
Marangos, P. J., Martino, A. M., Paul, S., and Skolnick, P., 1981, Psychopharmacology 72:269–273.
Anderson, L. T., David, R., Bonnet, K. A., and Dancis, J., 1979, Life Sci. 24:905–910.
Chiu, T. H., and Rosenberg, H. C., 1979, Eur. J. Pharmacol. 56:337–345.
Schlosger, W., and Franco, S., 1979, J. Pharmacol. Exp. Ther. 21:290–295.
Hunkeler, W., 1981, Nature 290:514–516.
Guidotti, A., Massotti, M., and Costa, E., 1980, Psychopharmacology and Biochemistry of Neurotransmitter Receptors ,(H. I. Yamamura, R. W. Olsen, and E. Usdin, eds.), Elsevier, Amsterdam, New York, pp. 655–660.
Saano, V., Urtti, A., and Airaksinen, M. M., 1981, Pharmacol. Res. Commun. 13:75–85.
Simantov, R., Oster-Granite, M. L., Herndon, R. M., and Snyder, S. H., 1976, Brain Res. 105:365–371.
Shibuya, H., Gale, K., and Pert, C. B., 1980, Eur. J. Pharmacol. 62:243–244.
Kellogg, C., Tervo, D., Ison, J., and Parisi, T., 1980, Science 207:205–207.
Rosengarten, H., and Friedhoff, A. J., 1979, Science 203:1133–1135.
Friedhoff, A. J., 1977, Comp. Psychiatry 18:309–317.
Friedhoff, A. J., and Alpert, M., 1978, Psychopharmacology: A Generation of Progress (M. Lipton, A. DiMascio and K. F. Killam, eds.), Raven Press, New York, pp. 797–801.
Alpert, M., and Friedhoff, A. J., 1980, Tardive Dyskinesia: Research and Treatment (W. E. Fann, J. M. Davis, R. C. Smith, and E. F. Domino, eds.), Spectrum, New York, pp. 471– 474.
Alpert, M., Friedhoff, A. J., Marcos, L. R., and Diamond, F., 1978, Am. J. Psychiatry 135:1329–1332.
Yaryura-Tobias, J. A., Wolpert, A., Dana, L., and Merlis, S., 1970, Dis. Nerv. Syst. 31:60–63.
Beramendi, V., Alpert, M., Guimon, J., Friedhoff, A. J., and Gutierrez, M., 1980, Arch. Neurobiol. 43:107–124.
Gutierrez, M., Alpert, M., Guimon, M., Friedhoff, A. J., and Bermendi, V., 1979, Infor maciones Psiquiatricas 2º-Trimestre ,No. 75, Barcelona, pp. 99–107.
Alpert, M., Friedhoff, A. J., and Diamond, F., 1983, in Advances in Neurology, Vol. 37: Experimental Therapeutics of Movement Disorders (S. Fahn, D. B. Calne, and I. Shoulson, eds.), Raven Press, New York, pp. 253–258.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Springer Science+Business Media New York
About this chapter
Cite this chapter
Schweitzer, J.W., Bonnet, K.A., Friedhoff, A.J. (1984). Receptor Adaptation to Psychotropic Drugs. In: Lajtha, A. (eds) Handbook of Neurochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4568-8_24
Download citation
DOI: https://doi.org/10.1007/978-1-4684-4568-8_24
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-4570-1
Online ISBN: 978-1-4684-4568-8
eBook Packages: Springer Book Archive