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Handbook of Neurochemistry pp 527–539Cite as

Phospholipid Methylation

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Abstract

Phospholipid methylation is a reaction in which phosphatidylethanolamine (PtdEth) is converted to phosphatidylcholine (PtdCho). This reaction was first described by Bremer et al.1 However, the enzyme activity of phospholipid methylation is quite low compared with CDP-choline transferese activity in PdtCho synthesis. For long time, this enzyme activity had not been detected in tissues other than lung and liver. Recently, many laboratories have reported the existence of PtdEth methyltransferase activity in a variety of organs and tissues of mammals. This enzyme activity in many tissues if not all, has now been connected to certain biological functions such as receptor-mediated signal transduction.2 In this chapter, recent studies on phospholipid methylation and its role in biological functions are described.

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Authors and Affiliations

  1. Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, Maryland, 20205, USA

    Fusao Hirata

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  1. Fusao Hirata
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Editors and Affiliations

  1. Center for Neurochemistry, Wards Island, New York, USA

    Abel Lajtha

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Hirata, F. (1984). Phospholipid Methylation. In: Lajtha, A. (eds) Handbook of Neurochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4568-8_19

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  • DOI: https://doi.org/10.1007/978-1-4684-4568-8_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4570-1

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