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Ethanol Induced Alterations of Uric Acid Metabolism

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Purine Metabolism in Man-IV

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 165))

Abstract

Early studies by Lieber and MacLachlan presented evidence suggesting that ethanol led to hyperlactic acidemia and decreased the excretion of uric acid.1,2 Delbarre indicated the possibility of increased urate production3 and a study by Grunst, et al. suggested that ethanol infusion lead to increased release of uric acid from the liver.4 We have reexamined whether ethanol-induced hyperuricemia may be related to decreased renal excretion of uric acid, increased urate production by either accelerated degradation of nucleotides or increased de novo synthesis or both mechanisms together.

Supported by USPHS grant AM19674 and 5 MO1 RR00042 from Michigan Heart Association and Warner/Lambert-Parke/Davis.

Dr. Faller is supported by an Arthritis Foundation Postdoctoral Fellowship.

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References

  1. C.S. Lieber, D.P. Jones, M.S. Losowsky and C.S. Davidson, J. Clin. Invest. 41: 1863 (1962).

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  2. M.J. MacLachlan, G.P. Rodnan, Am. J. Med. 42: 38 (1967).

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  3. F. Delbarre, C. Auscher, H. Brouilhet and A. deGery, Sem. Hop. Paris 43: 659–664 (1967).

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  4. J. Grunst, G. Dietze and M. Wicklmayr, Nutr. Metab. 21 (Suppl. 1) 138 (1977).

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  5. R.L. Veech, R. Guyinn and D. Veloso, Biochem. J. 127: 387 (1972).

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  6. J. Grunst, G. Dietze and M. Wickimayr, Leber. Verh. Dt. Ges. inn Med. 79: 941–917 (1973).

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Author information

Authors and Affiliations

  1. The Human Purine Research Center Departments of Internal Medicine and Biological Chemistry, University Hospitals, Ann Arbor, Michigan, USA

    Jason Faller & Irving H. Fox

Authors
  1. Jason Faller
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  2. Irving H. Fox
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Editor information

Editors and Affiliations

  1. University of Nijmegen Faculty of Medicine, Nijmegen, The Netherlands

    Chris H. M. M. De Bruyn

  2. Guy’s Hospital Medical School, London, UK

    H. Anne Simmonds

  3. University of Vienna, Vienna, Austria

    Mathias M. Müller

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© 1984 Plenum Press, New York

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Faller, J., Fox, I.H. (1984). Ethanol Induced Alterations of Uric Acid Metabolism. In: De Bruyn, C.H.M.M., Simmonds, H.A., Müller, M.M. (eds) Purine Metabolism in Man-IV. Advances in Experimental Medicine and Biology, vol 165. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4553-4_90

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  • DOI: https://doi.org/10.1007/978-1-4684-4553-4_90

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4555-8

  • Online ISBN: 978-1-4684-4553-4

  • eBook Packages: Springer Book Archive

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