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The Identification of Amitriptyline and Benzodiazepine Metabolites

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Drug Metabolite Isolation and Determination

Part of the book series: Methodological Surveys in Biochemistry and Analysis ((ANAY,volume 12))

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Abstract

HPLC peaks in an assay developed for amitriptyline and its metabolites were of unclear identity, elucidated by certain approaches. The accuracy of a semi-quantitative EMIT procedure for benzodiazepines was validated. Determining the contribution of metabolites to a drug assay poses problems to a clinically oriented laboratory, as these studies illustrate.

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References

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Author information

Authors and Affiliations

  1. Department of Biochemistry, Royal Infirmary, Glasgow, G4 0SF, UK

    Ian D. Watson, David R. Jarvie, Anne Chambers & Michael J. Stewart

  2. Department of Clinical Chemistry, Royal Infirmary, Edinburgh, EH3 9YW, UK

    David R. Jarvie

Authors
  1. Ian D. Watson
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  2. David R. Jarvie
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  3. Anne Chambers
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  4. Michael J. Stewart
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Editor information

Editors and Affiliations

  1. University of Surrey, UK

    Eric Reid  & J. P. Leppard  & 

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© 1983 Plenum Press, New York

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Watson, I.D., Jarvie, D.R., Chambers, A., Stewart, M.J. (1983). The Identification of Amitriptyline and Benzodiazepine Metabolites. In: Reid, E., Leppard, J.P. (eds) Drug Metabolite Isolation and Determination. Methodological Surveys in Biochemistry and Analysis, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4484-1_14

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  • DOI: https://doi.org/10.1007/978-1-4684-4484-1_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4486-5

  • Online ISBN: 978-1-4684-4484-1

  • eBook Packages: Springer Book Archive

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