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A Note on Quantitation of14C Radioactivity in HPLC Eluates

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Drug Metabolite Isolation and Determination

Part of the book series: Methodological Surveys in Biochemistry and Analysis ((ANAY,volume 12))

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Abstract

The main advantage associated with the use of radiolabelled compounds in HPLC, as extensively practised in our Section’s studies of potential drugs, is that a simple non-specific method of detection applies to all labelled components derived from the drug without interference from sample-associated impurities.

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Relevant literature

  1. Mackey, L.N., Rodriguez, P.A. & Schroeder, F.B. (1981)J. Chromatog. 208, 1–8.

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© 1983 Plenum Press, New York

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Roberts, D.W. (1983). A Note on Quantitation of14C Radioactivity in HPLC Eluates. In: Reid, E., Leppard, J.P. (eds) Drug Metabolite Isolation and Determination. Methodological Surveys in Biochemistry and Analysis, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4484-1_12

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  • DOI: https://doi.org/10.1007/978-1-4684-4484-1_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4486-5

  • Online ISBN: 978-1-4684-4484-1

  • eBook Packages: Springer Book Archive

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