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Genetic Disorders of Granulocyte Function: What they Tell Us about Normal Mechanisms

  • Conference paper
Host Defenses to Intracellular Pathogens

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 162))

Abstract

Clinically significant genetic defects of phagocyte function have been most clearly defined for polymorphonuclear leukocytes (PMN). Several important lessons have been learned from an analysis of these defects. These include:

  1. 1)

    Defining the role of oxidative metabolism in the microbicidal activity of PMNs;

  2. 2)

    determining the existence and activity of “back-up” killing mechanisms when deletions in normal pathways occur, and;

  3. 3)

    discerning the importance of PMNs relative to other cells in host defense against different microorganisms.

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Author information

Authors and Affiliations

  1. Department of Internal Medicine, Yale University, New Haven, Connecticut, 06510, USA

    Richard K. Root

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  1. Richard K. Root
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Editor information

Editors and Affiliations

  1. Temple University School of Medicine, Philadelphia, Pennsylvania, USA

    Toby K. Eisenstein

  2. Smith, Kline, and French Laboratories, Philadelphia, Pennsylvania, USA

    Paul Actor

  3. College of Medicine, University of South Florida, Tampa, Florida, USA

    Herman Friedman

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© 1983 Plenum Press, New York

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Root, R.K. (1983). Genetic Disorders of Granulocyte Function: What they Tell Us about Normal Mechanisms. In: Eisenstein, T.K., Actor, P., Friedman, H. (eds) Host Defenses to Intracellular Pathogens. Advances in Experimental Medicine and Biology, vol 162. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4481-0_5

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  • DOI: https://doi.org/10.1007/978-1-4684-4481-0_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4483-4

  • Online ISBN: 978-1-4684-4481-0

  • eBook Packages: Springer Book Archive

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