Skip to main content
SpringerLink
Log in
Book cover

Host Defenses to Intracellular Pathogens pp 441–447Cite as

Virus-Immune T Cells and Monoclonal Antibodies in the Mouse Influenza Model

  • Conference paper

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 162))

Abstract

Evidence has been accumulating over the past 10 years that a major factor in recovery from most acute virus infections is the cellular immune response mediated by T cells which are, when tested in vitro, cytotoxic for virus-infected target cells (reviewed in 1 and 2). The recent development of techniques for producing theoretically unlimited amounts of virus-specific monoclonal antibodies has raised the possibility that such reagents may prove to be of great therapeutic value (3,4). We wish to summarize here our current understanding of the possible interactions between monoclonal antibodies and virus-immune T cells in the influenza model. It will be obvious to the reader that these experiments are still at a very early stage, though some useful insights are emerging.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Zinkernagel, R.M. and Doherty, P.C. (1977) Adv. Immunol. 27, 51.

    Article  Google Scholar 

  2. Doherty, P.C. (1970) Prog. Immunol. 4, 563.

    Google Scholar 

  3. Koprowski, H., Gerhard, W., and Croce, C.M. (1977) Proc. Natl. Acad. Sci. (USA) 74, 2985.

    Article  CAS  Google Scholar 

  4. Gerhard, W.U., Yewdell, J., Frankel, M.E., Lopes, A.D. and Staudt, L. (1980) in “Monoclonal antibodies”, R.H. Kennett, T.J. McKearn and K.B. Bechtol, eds., Plenum Press, New York, p. 317.

    Google Scholar 

  5. Doherty, P.C., and Bennink, J.R. (1981) Fed. Proc. 40, 218.

    PubMed  CAS  Google Scholar 

  6. Blanden, R.V. (1974) Transplant, Rev. 19, 56.

    CAS  Google Scholar 

  7. Yap, K.L., Ada, G.L. and McKenzie, I.F.C. (1978) Nature 273, 238.

    Article  PubMed  CAS  Google Scholar 

  8. Finberg, R., Mescher, M. and Burakoff, S.J. (1978) J. Exp. Med. 148, 1620.

    Article  PubMed  CAS  Google Scholar 

  9. Hale, A.H. and Ruebush, M.H. (1980) J. Immunol. 125, 1569.

    PubMed  CAS  Google Scholar 

  10. Zinkernagel, R.M. and Rosenthal, K.L. (1980) Immunol. Rev, 58, 134.

    Google Scholar 

  11. Kilbourne, E.D. (1975) “The Influenza Viruses and Influenza”, Academic Press, New York.

    Google Scholar 

  12. Effros, R.B., Doherty, P.C., Gerhard, W., and Bennink, J.R. (1977) J. Exp. Med. 145, 557.

    Article  PubMed  CAS  Google Scholar 

  13. Doherty, P.C., Effros, R.B. and Bennink, J.R. (1977) Proc. Nat. Acad. Sci. (USA) 74, 1209.

    Article  CAS  Google Scholar 

  14. Zweerink, H.J., Courtneidge, S.A., Skehel, T.J., Crumpton, M. and Askonas, B.A. (1977) Nature 267, 354.

    Article  PubMed  CAS  Google Scholar 

  15. Lu, L.Y. and Askonas, B.A. (1980) Nature 288, 164.

    Article  PubMed  CAS  Google Scholar 

  16. Braciale, T.J., Andrew, M.E. and Braciale, V.L. (1981) J. Exp. Med. 153, 910.

    Article  PubMed  CAS  Google Scholar 

  17. Koszinowski, U.H., Allen, H., Gething, M.J., Waterfield, M.D. and Klenk, H.D. (1980) J. Exp. Med. 151, 945.

    Article  PubMed  CAS  Google Scholar 

  18. Yewdell, J., Frank, E. and Gerhard, W. (1981) J. Immunol. 126, 1814

    PubMed  CAS  Google Scholar 

  19. McMichael, A.J. and Askonas, B.A. (1978) Eur. J. Immunol. 8, 705.

    Article  PubMed  CAS  Google Scholar 

  20. Biddison, W.E., Shaw, S. and Nelson, D.L. (1979) J, Immunol. 122, 660.

    CAS  Google Scholar 

  21. Marshak, A., Doherty, P.C. and Wilson, D.B. (1977) J. Exp. Med. 146, 1773.

    Article  PubMed  CAS  Google Scholar 

  22. Lopes, A.D. (1981) Ph.D. Thesis, University of Pennsylvania.

    Google Scholar 

  23. Gerhard, W., Yewdell, J., and Frankel, M.E. (1981) Nature 290, 713.

    Article  PubMed  CAS  Google Scholar 

  24. Doherty, P.C. and Gerhard, W. (1981) J. Neuroimmunol. 1, in press.

    Google Scholar 

  25. Mims, C.A. (1960) Brit. J. Exp. Path. 46, 586.

    Google Scholar 

  26. Effros, R.B., Frankel, M.E., Gerhard, W. and Doherty, P.C. (1979) J. Immunol. 123, 1343.

    PubMed  CAS  Google Scholar 

  27. Greenspan, N. (1981) Ph.D. Thesis, University of Pennsylvania.

    Google Scholar 

  28. Frankel, W.E., Effros, R.B., Doherty, P.C. and Gerhard, W.U. (1979) J. Immunol. 123, 2438.

    PubMed  CAS  Google Scholar 

  29. Zinkernagel, R.M. and Doherty, P.C. (1974) Nature 251, 547.

    Article  PubMed  CAS  Google Scholar 

  30. Doherty, P.C. (1980) in “Strategies of Immune Regulation”, E. Sercarz and A. Cunningham, eds., Academic Press, New York, p. 103.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Wistar Institute, 36th and Spruce Streets, Philadelphia, PA, 19104, USA

    Peter C. Doherty, Neil Greenspan, A. Dwight Lopes & Walter Gerhard

Authors
  1. Peter C. Doherty
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Neil Greenspan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Dwight Lopes
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Walter Gerhard
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Temple University School of Medicine, Philadelphia, Pennsylvania, USA

    Toby K. Eisenstein

  2. Smith, Kline, and French Laboratories, Philadelphia, Pennsylvania, USA

    Paul Actor

  3. College of Medicine, University of South Florida, Tampa, Florida, USA

    Herman Friedman

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Plenum Press, New York

About this paper

Cite this paper

Doherty, P.C., Greenspan, N., Lopes, A.D., Gerhard, W. (1983). Virus-Immune T Cells and Monoclonal Antibodies in the Mouse Influenza Model. In: Eisenstein, T.K., Actor, P., Friedman, H. (eds) Host Defenses to Intracellular Pathogens. Advances in Experimental Medicine and Biology, vol 162. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4481-0_40

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-4481-0_40

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4483-4

  • Online ISBN: 978-1-4684-4481-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation