Abstract
L. tropica, an obligate intracellular parasite, replicates in phagolysosomes of macrophages. Resistance to L. tropica infection may depend upon alteration of this intracellular environment (1,2). Soluble products of antigen- or mitogen-stimulated lymphocytes (lymphokines) induce enhanced macrophage antimicrobial activity against a number of intracellular organisms (3,4,5,6,7). These activated macrophages may be effector cells during resolution of L. tropica infections. In this study we analyzed the interaction of L. tropica and macrophages treated with lymphokines in vitro, and correlated these findings with susceptibility to L. tropica infection in vivo.
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References
Chang, K.P., and Dwyer, D.M. (1976). Sci. 193:678.
Chang, K.P., and Dwyer, D.M. (1976). Sci. 193:687.
Fowles, R.E., Fajardo, I.M., Leibavitch, J.L., and David, J.R. (1973). J. Exp. Med. 148:393.
Godai, T., Rees, R.J.W., and Lamvik, J.O. (1971). Clin. Exp. Immunol. 8:625.
Borges, J.S., and Johnson, W.D. (1975). J. Exp. Med. 141:483.
Nogiera, N., and Cohn, Z.A. (1978). J. Exp. Med. 148:288.
Nacy, C.A., and Meltzer, M.S. (1979). J. Immunol. 123:2544.
Nacy, C.A., Meltzer, M.S., Leonard, E.J., and Wyler, D.J. (submitted).
Boraschi, D., and Meltzer, M.S. (1979). Cell. Immunol. 45:188.
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© 1983 Plenum Press, New York
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Haverly, A.L., Pappas, M.G., Henry, R.R., Nacy, C.A. (1983). In Vitro Macrophage Antimicrobial Activities and In Vivo Susceptibility to Leishmania Tropica Infection. In: Eisenstein, T.K., Actor, P., Friedman, H. (eds) Host Defenses to Intracellular Pathogens. Advances in Experimental Medicine and Biology, vol 162. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4481-0_39
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DOI: https://doi.org/10.1007/978-1-4684-4481-0_39
Publisher Name: Springer, Boston, MA
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