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Intracellular Destruction of Leishmania Tropica by Macrophages Activated in Vivo with Mycobacterium Bovis Strain BCG

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Host Defenses to Intracellular Pathogens

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 162))

Abstract

Leishmania tropica, an intracellular protozoan parasite, infects and replicates in macrophages of C3H/HeN and C3H/HeJ mice in vitro (1). Exposure of resident peritoneal macrophages to amastigotes for 1 hr results in 20–25% infected macrophages, Intracellular parasites increase from 1.7 to >3.5 per macrophage over 72 hr.

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Author information

Authors and Affiliations

  1. Department of Immunology, Walter Reed Army Institute of Research, Washington, D.C., 20012, USA

    Michael G. Pappas, Charles N. Oster & Carol A. Nacy

Authors
  1. Michael G. Pappas
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  2. Charles N. Oster
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  3. Carol A. Nacy
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Editor information

Editors and Affiliations

  1. Temple University School of Medicine, Philadelphia, Pennsylvania, USA

    Toby K. Eisenstein

  2. Smith, Kline, and French Laboratories, Philadelphia, Pennsylvania, USA

    Paul Actor

  3. College of Medicine, University of South Florida, Tampa, Florida, USA

    Herman Friedman

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© 1983 Plenum Press, New York

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Pappas, M.G., Oster, C.N., Nacy, C.A. (1983). Intracellular Destruction of Leishmania Tropica by Macrophages Activated in Vivo with Mycobacterium Bovis Strain BCG. In: Eisenstein, T.K., Actor, P., Friedman, H. (eds) Host Defenses to Intracellular Pathogens. Advances in Experimental Medicine and Biology, vol 162. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4481-0_38

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  • DOI: https://doi.org/10.1007/978-1-4684-4481-0_38

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4483-4

  • Online ISBN: 978-1-4684-4481-0

  • eBook Packages: Springer Book Archive

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