Abstract
The role of cell-mediated immunity (CMI) has been shown to be a major factor in acquired resistance to the obligate intracellular parasite R. tsutsugamushi. Specifically, it has been shown that immune animals possess spleen cells with the characteristics of thymus-derived lymphocytes (T-Cells) which confer protection against subsequent challenge when transferred to naive mice (9). The interaction of antigens with specifically sensitized T-cells can be demonstrated in vivo by a delayed-typed hypersensitivity (DTH) response (6), or in vitro by a specific antigen induced lymphocyte proliferative (LP) response (7).
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© 1983 Plenum Press, New York
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Jerrells, T.R., Osterman, J.V. (1983). Parameters of Cellular Immunity in Acute and Chronic Rickettsia Tsutsugamushi Infections of Inbred Mice. In: Eisenstein, T.K., Actor, P., Friedman, H. (eds) Host Defenses to Intracellular Pathogens. Advances in Experimental Medicine and Biology, vol 162. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4481-0_33
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DOI: https://doi.org/10.1007/978-1-4684-4481-0_33
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