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Strain Dependent Variation of Delayed-Type Hypersensitivity in Salmonella Typhimurium Infected Mice

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Host Defenses to Intracellular Pathogens

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 162))

Abstract

Development of delayed-type hypersensitivity (DTH) in Salmonella infection was reported as early as 1923, when Zinsser showed that guinea pigs injected with live typhoid bacilli became skin test positive to typhoid antigen (1). A close relationship between DTH and immunity to Salmonella infection was demonstrated in mice by Collins and Mackaness (2). They showed that mice immunized with live Salmonella developed DTH as measured by an increase in footpad thickness 24 hours after injection of a culture supernatant antigen. The appearance of footpad responsiveness correlated with the onset of immunity to challenge with virulent Salmonella (2).

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References

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Author information

Authors and Affiliations

  1. Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA, USA

    Loran Killar & Toby K. Eisenstein

Authors
  1. Loran Killar
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  2. Toby K. Eisenstein
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Editor information

Editors and Affiliations

  1. Temple University School of Medicine, Philadelphia, Pennsylvania, USA

    Toby K. Eisenstein

  2. Smith, Kline, and French Laboratories, Philadelphia, Pennsylvania, USA

    Paul Actor

  3. College of Medicine, University of South Florida, Tampa, Florida, USA

    Herman Friedman

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© 1983 Plenum Press, New York

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Killar, L., Eisenstein, T.K. (1983). Strain Dependent Variation of Delayed-Type Hypersensitivity in Salmonella Typhimurium Infected Mice. In: Eisenstein, T.K., Actor, P., Friedman, H. (eds) Host Defenses to Intracellular Pathogens. Advances in Experimental Medicine and Biology, vol 162. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4481-0_27

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  • DOI: https://doi.org/10.1007/978-1-4684-4481-0_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4483-4

  • Online ISBN: 978-1-4684-4481-0

  • eBook Packages: Springer Book Archive

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