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Host Response to Infection with Mycobacterium Bovis (BCG) in Mice: Genetic Study of Natural Resistance

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Host Defenses to Intracellular Pathogens

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 162))

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Abstract

Resistance of mice to several infectious agents has recently been shown to be under simple genetic control (reviewed in 1). Genetic differences in the response of outbred and inbred mice to infection with mycobacteria such as Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium lepraemurium have been noted for many years (2,3). We have recently reported that clear segregation of resistance and susceptibility to Mycobacterium bovis (BCG), exists among mice of inbred strains infected with a single intravenous dose of this bacillus (4). The present study deals with detailed genetic analysis of the trait of BCG resistance.

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References

  1. Genetic Control of Natural Resistance to Infection and Malignancy. Edited by Skamene, E., Kongshavn, P.A.L. and Landy, M. Academic Press, New York, 1980.

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Author information

Authors and Affiliations

  1. Montreal General Hospital Research Institute, Montreal, Quebec, Canada

    Philippe Gros & Emil Skamene

  2. University of Montreal, Montreal, Quebec, Canada

    Adrien Forget

  3. Jackson Laboratories, Bar Harbor, Maine, USA

    Ben Taylor

Authors
  1. Philippe Gros
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  2. Emil Skamene
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  3. Adrien Forget
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  4. Ben Taylor
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Editor information

Editors and Affiliations

  1. Temple University School of Medicine, Philadelphia, Pennsylvania, USA

    Toby K. Eisenstein

  2. Smith, Kline, and French Laboratories, Philadelphia, Pennsylvania, USA

    Paul Actor

  3. College of Medicine, University of South Florida, Tampa, Florida, USA

    Herman Friedman

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© 1983 Plenum Press, New York

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Gros, P., Skamene, E., Forget, A., Taylor, B. (1983). Host Response to Infection with Mycobacterium Bovis (BCG) in Mice: Genetic Study of Natural Resistance. In: Eisenstein, T.K., Actor, P., Friedman, H. (eds) Host Defenses to Intracellular Pathogens. Advances in Experimental Medicine and Biology, vol 162. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4481-0_17

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  • DOI: https://doi.org/10.1007/978-1-4684-4481-0_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4483-4

  • Online ISBN: 978-1-4684-4481-0

  • eBook Packages: Springer Book Archive

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