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Immunodepression in BALB/c Mice Infected with Leishmania Tropica

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Host Defenses to Intracellular Pathogens

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 162))

Abstract

Leishmania tropica is an obligate intracellular parasite of macrophages which causes cutaneous leishmaniasis in man. Infections in BALB/c mice with this parasite are characterized by the development of large primary ulcers and multiple non-healing metastatic cutaneous lesions (1,2,3). To date, the immunological mechanisms responsible for the inability of BALB/c mice to resolve leishmanial infections are unknown; however, specific suppressor T cells responsible for regulating skin test responses to leishmanial antigens have been reported (3,4). In addition, BALB/c mice infected with L. tropica develop a non-specific immunodepression, as described in this report. This immunodepression is mediated by an adherent suppressor cell which suppresses mitogen and leishmanial antigen responses in a lymphocyte transformation assay.

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References

  1. Bjorvatn, B., and Neva, F.A. (1979). Am. J. Trop. Med. Hyg. 28:472–479.

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  2. Howard, J.G., Hale, C. and Liew, F.Y. (1980). J. Exp. Med. 152:594–607.

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  3. DeTolla, L.J., Scott, P.A. and Farrell, J.P., Immunogenetics (in press).

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  4. Howard, J.G., Hale, C. and Liew, F.Y. (1981). J. Exp. Med. 153–568.

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  5. Ly, I.A. and Mishell, R.I. (1974). J. Immunol. Meth. 5:239–247.

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Author information

Authors and Affiliations

  1. Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Phillip A. Scott & Jay P. Farrell

Authors
  1. Phillip A. Scott
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  2. Jay P. Farrell
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Editor information

Editors and Affiliations

  1. Temple University School of Medicine, Philadelphia, Pennsylvania, USA

    Toby K. Eisenstein

  2. Smith, Kline, and French Laboratories, Philadelphia, Pennsylvania, USA

    Paul Actor

  3. College of Medicine, University of South Florida, Tampa, Florida, USA

    Herman Friedman

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© 1983 Plenum Press, New York

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Scott, P.A., Farrell, J.P. (1983). Immunodepression in BALB/c Mice Infected with Leishmania Tropica . In: Eisenstein, T.K., Actor, P., Friedman, H. (eds) Host Defenses to Intracellular Pathogens. Advances in Experimental Medicine and Biology, vol 162. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4481-0_15

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  • DOI: https://doi.org/10.1007/978-1-4684-4481-0_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4483-4

  • Online ISBN: 978-1-4684-4481-0

  • eBook Packages: Springer Book Archive

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