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Host Defenses to Intracellular Pathogens pp 127–143Cite as

Macrophage Oxygen-Dependent Killing of Intracellular Parasites: Toxoplasma and Leishmania

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 162))

Abstract

The importance of cell-mediated immunity in host resistance to infection caused by intracellular pathogens has been well-established. Similarly, it has been known for some time that monocytes and macrophages play primary roles in the efferent limb of the cellular response to such infections (1–9). The mechanisms by which these phagocytes exert antimicrobial activity, however, have been largely unexplored. During the past several years, work in this and other laboratories has indicated that the generation of toxic oxygen intermediates contributes importantly to the ability of mononuclear phagocytes to kill or inhibit the growth of ingested microbial pathogens (10–20). Thus, considerable evidence is now available to suggest that the well-recognized oxygen-dependent mechanism present in polymorphonuclear leukocytes, which generates a number of toxic products including superoxide anion (O -2 ), hydrogen peroxide (H2O2), and hydroxyl radical (OH) (21–23), is also present and operative in monocytes and macrophages.

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Author information

Authors and Affiliations

  1. Cornell University Medical College, New York, NY, USA

    Henry W. Murray

Authors
  1. Henry W. Murray
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Editor information

Editors and Affiliations

  1. Temple University School of Medicine, Philadelphia, Pennsylvania, USA

    Toby K. Eisenstein

  2. Smith, Kline, and French Laboratories, Philadelphia, Pennsylvania, USA

    Paul Actor

  3. College of Medicine, University of South Florida, Tampa, Florida, USA

    Herman Friedman

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© 1983 Plenum Press, New York

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Murray, H.W. (1983). Macrophage Oxygen-Dependent Killing of Intracellular Parasites: Toxoplasma and Leishmania. In: Eisenstein, T.K., Actor, P., Friedman, H. (eds) Host Defenses to Intracellular Pathogens. Advances in Experimental Medicine and Biology, vol 162. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4481-0_13

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  • DOI: https://doi.org/10.1007/978-1-4684-4481-0_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4483-4

  • Online ISBN: 978-1-4684-4481-0

  • eBook Packages: Springer Book Archive

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