Abstract
Acetylcholine is released from parasympathetic nerve terminals and binds to muscarinic acetylcholine (mACh) receptors to elicit negative chronotropic and inotropic effects on the heart. The molecular mechanisms for these cardiac effects are not well understood. Investigation of the mACh receptor has been greatly facilitated by the development of the potent cholinergic antagonist [3H] quinuclidinyl benzilate (QNB) which binds specifically and with high affinity to the mACh receptor (1). [3H]QNB can be used to study the interaction of agonists and antagonists with the receptor and quantitate the number of receptors present in cells and tissues.
Keywords
- Adenylate Cyclase
- Muscarinic Receptor
- Adenylate Cyclase Activity
- Receptor Number
- Muscarinic Acetylcholine Receptor
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© 1983 Plenum Press, New York
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Halvorsen, S.W., Engel, B., Hunter, D.D., Nathanson, N.M. (1983). Development and Regulation of Cardiac Muscarinic Acetylcholine Receptor Number, Function and Gyanyl Nucleotide Sensitivity. In: Spitzer, J.J. (eds) Myocardial Injury. Advances in Experimental Medicine and Biology, vol 161. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4472-8_8
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DOI: https://doi.org/10.1007/978-1-4684-4472-8_8
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