Beta-Adrenergic Stimulation of Adenylate Cyclase and Alpha-Adrenergic Inhibition of Adenylate Cyclase: GTP-Binding Proteins as Macromolecular Messengers
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This review, which is a summary of an oral presentation made at the International Study Group for Research in Cardiac Metabolism, is a brief synopsis of work in our laboratory concerning the mechanism of hormonal regulation of adenylate cyclase. By its very nature, it refers almost entirely to our own work. However, since a number of laboratories have contributed to the field in ways at least as significant as our own, I recommend reading the reviews cited as references 4, 7 and 11 for a more comprehensive summary of the literature. The emphasis of this review is the role of GTP-binding proteins as important communicators between hormone-occupied receptors and the catalytic subunit of adenylate cyclase. The experimental work summarized emphasizes the extent to which one can determine the “intactness” receptor-effector coupling by focusing on receptor-agonist interactions, and modulation of these interactions by guanine nucleotides.
KeywordsAdenylate Cyclase Cholera Toxin Guanine Nucleotide Adenylate Cyclase Activity Large Molecular Size
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