The Role of Cell-to-Cell Coupling in Cardiac Conduction Disturbances

  • Madison S. Spach
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 161)


The propagation of electrical excitation in cardiac muscle has, since its identification more than a century ago, generally been treated as though it occurred in a continuous structure. While it has been well-appreciated that cardiac muscle is composed of individual cells connected together by low resistance connections, it has been considered that the electrical effects of the structural complexity produced by the connections between cells and between bundles are of minor importance, presumably to have the tissue fit a simple model for useful theoretical analysis. Because of this, most analyses of cardiac conduction have been based on the simplifying assumption that the structure has the electrical properties of continuously uniform geometry and intracellular resistivity in the direction of propagation.


Muscle Bundle Conduction Disturbance Extracellular Potential Branch Site Extracellular Potassium Concentration 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Madison S. Spach
    • 1
  1. 1.Departments of Pediatrics and PhysiologyDuke University Medical CenterDurhamUSA

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