A Molecular Biologic Approach to Cardiac Toxicology
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Molecular biology seeks to depict biological function in terms of discrete events, individually accessible to biochemical study. With the myocardial cell this approach has had some success. The affinity of receptors for a variety of drugs, the ionic basis for signal transmission across the sarcolemmal membrane, and the enzymatic components of the various membranes that control internal calcium, have been studied and provide a rationale for at least some of the reversible, pharmacologically induced dysfunctions that represent the side effects of conventional drugs on this cell. This symposium, however, deals largely with chemical agents which initiate sequences of incompletely understood events that lead ultimately to irreversible tissue damage and cell death. Among these effects, the myocardial necrosis produced by suprapharmacological concentrations of isoproterenol has been of special interest because its production may have some elements in common with infarction or ischemic damage and because it induces resistance to further chemical damage.
KeywordsXanthine Oxidase Myocardial Necrosis Free Radical Damage Spin Trapping Sarcolemmal Membrane
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