Cellular Immune Mechanisms in Coxsackievirus Group B, Type 3 Induced Myocarditis in Balb/C Mice

  • Sally A. Huber
  • Lilian P. Job
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 161)


Coxsackie B viruses are a common cause of viral myocarditis in humans. A murine model of the human disease has been developed using Coxsackievirus group B, type 3 and inbred Balb/c mice. Infection of T lymphocyte deficient mice does not result in significant myocarditis indicating the importance of T cells in this disease. The virus can be isolated from the hearts of T cell deficient and normal mice in equal concentrations. Virus elimination presumably is mediated by virus specific neutralizing antibody induced in both groups. T lymphocytes, natural killer cells and macrophage obtained from normal virus infected mice are all capable of lysing myofibers in vitro. Maximum lysis is obtained with the cytolytic T cells. When these cell populations or Coxsackievirus immune antibody were adoptively transferred into T lymphocyte deficient animals infected with the virus, only animals given T cells developed significant myocarditis.


Spleen Cell Cytolytic Activity Plaque Form Unit Viral Myocarditis Coxsackie Virus 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Sally A. Huber
    • 1
  • Lilian P. Job
    • 1
  1. 1.Department of PathologyUniversity of VermontBurlingtonUSA

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