Cellular Immune Mechanisms in Coxsackievirus Group B, Type 3 Induced Myocarditis in Balb/C Mice
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Coxsackie B viruses are a common cause of viral myocarditis in humans. A murine model of the human disease has been developed using Coxsackievirus group B, type 3 and inbred Balb/c mice. Infection of T lymphocyte deficient mice does not result in significant myocarditis indicating the importance of T cells in this disease. The virus can be isolated from the hearts of T cell deficient and normal mice in equal concentrations. Virus elimination presumably is mediated by virus specific neutralizing antibody induced in both groups. T lymphocytes, natural killer cells and macrophage obtained from normal virus infected mice are all capable of lysing myofibers in vitro. Maximum lysis is obtained with the cytolytic T cells. When these cell populations or Coxsackievirus immune antibody were adoptively transferred into T lymphocyte deficient animals infected with the virus, only animals given T cells developed significant myocarditis.
KeywordsSpleen Cell Cytolytic Activity Plaque Form Unit Viral Myocarditis Coxsackie Virus
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- 4.Doherty, P.C., Blanden, R.V. and Zinkernagel, R.M. Specificity of virus-immune effector T cells for H-2K or H-2D compatible interactions: Implications for H-antigen diversity. Transplantation Review 29, 89–124 (1976)Google Scholar
- 6.Fidler, I.J. Activation in vitro of mouse macrophages by syngeneic, allogeneic or xenogeneic lymphocyte supernatants. Journal of National Cancer Institute 55, 1159–1163 (1975)Google Scholar
- 11.Huber, S.A., Job, L.P., Auld, K.R. and Woodruff, J.F. Sex-related differences in the rapid production of cytotoxic spleen cells active against uninfected myofibers during Coxsackievirus B-3 infection. Journal of Immunology 126, 1336–1340 (1981)Google Scholar
- 13.Kim, Y-B., Huk, N.D., Koren, H.S. and Amos, D.B. Natural killing (NK) and antibody-dependent cellular cytotoxicity (ADCC) in specific pathogen-free (SPF) miniature swine and germ-free piglets. I comparison of NK and ADCC. Journal of Immunology 125, 755–762 (1980).Google Scholar
- 15.Lerner, A.M. and Wilson, F.M. Virus myocaridopathy. Progress in Medical Virology 15, 63–91 (1973)Google Scholar
- 17.Oldstone, M.B.A. Virus neutralization and virus-induced immune complex disease. Progress in Medical Virology 19, 84–119 (1975)Google Scholar
- 22.Woodruff, J.F. Lack of correlation between neutralizing antibody production and suppression of Coxsackievirus B-3 replication in target organs: Evidence for involvement of mononuclear inflammatory cells in host defense. Journal of Immunology 123, 31–36 (1979)Google Scholar
- 24.Woodruff, J.F. and Woodruff, J.J. Involvement of T lymphocytes in the pathogenesis of Coxsackie virus B-3 heart disease. Journal of Immunology 113, 1726–1734 (1974)Google Scholar