High Energy Phosphates, Anaerobic Glycolysis and Irreversibility in Ischemia

  • Robert B. Jennings
  • Keith A. Reimer
  • Robert N. Jones
  • Robert B. Peyton
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 161)


Results of recent studies of energy production in severe or total ischemia in the dog heart have shown a striking relationship between deficient supplies of high energy phosphate and the loss of much of the adenine nucleotide pool.1,2 The depletion of the adenine nucleotide pool in ischemia occurs because the ischemic tissue utilizes high energy phosphate at a greater rate than it can produce it by anaerobic glycolysis.2–6 Some of the interrelationships among anaerobic glycolysis, energy metabolism, and cell death will be reviewed in this paper.


Lactate Production Ischemic Tissue Anaerobic Glycolysis Severe Ischemia High Energy Phosphate 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Robert B. Jennings
    • 1
  • Keith A. Reimer
    • 1
  • Robert N. Jones
    • 1
  • Robert B. Peyton
    • 1
  1. 1.Departments of Pathology and SurgeryDuke University Medical CenterDurhamUSA

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