Aortic Perfusion Pressure and Protein Synthesis

  • Yuji Kira
  • Pamela Kochel
  • Howard E. Morgan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 161)


Cardiac hypertrophy is a compensatory mechanism utilized when the heart must do additional work. Immediately after imposition of an increased pressure load, an acceleration in the rate of protein synthesis must depend upon increased efficiency because sufficient time has not elapsed to allow for synthesis of increased numbers of ribosomes and other components of the pathway. Efficiency of synthesis refers to the rate at which amino acids are incorporated into protein when expressed as a function of tissue RNA, whereas capacity refers to the quantity of RNA present within the heart (Waterlow et al., 1978). When the effects of increased pressure load were studied in vitro, incorporation of amino acids into heart protein was accelerated by higher work loads in working heart preparations or by increased perfusion pressure in Langendorff preparations (Schreiber et al., 1966; Hjalmarson and Isaksson, 1972a; Morgan et al., 1980). In these circumstances, increased synthesis was thought to be related to development of higher levels of ventricular pressure.


Protein Synthesis Perfusion Pressure Aortic Pressure Myocardial Oxygen Consumption Coronary Perfusion Pressure 
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  1. Arnold, G., Kosche, F., Messner, E. , Neitzert, A., and Lochner, W. , 1968, The importance of the perfusion pressure in the coronary arteries for the contractility and oxygen consumption of the heart, Pflugers Archiv., 299:339.CrossRefGoogle Scholar
  2. Hjalmarson, A., and Isaksson, O., 1972a, In vitro work load and rat heart metabolism. I. Effect on protein synthesis, Acta Physiol. Scand., 86:126.Google Scholar
  3. Hjalmarson, A., and Isaksson, O., 1972b, In vitro work load and rat heart metabolism. III. Effect on ribosomal aggregation, Acta Physiol. Scand., 86:342.CrossRefGoogle Scholar
  4. Jefferson, L. S., Wolpert, E. B., Giger, K. E., and Morgan, H. E., 1971, Regulation of protein synthesis in heart muscle. III. Effect of anoxia on protein synthesis, J. Biol. Chem., 246:2171.PubMedGoogle Scholar
  5. McKee, E. E. , Cheung, J. Y. , Rannels, D. E., and Morgan, H. E., 1978, Measurement of the rate of protein synthesis and compartmentation of heart phenylalanine, J. Biol. Chem., 253:1030.PubMedGoogle Scholar
  6. Morgan, H. E., Chua, B. H. L., Fuller, E. O., and Siehl, D., 1980, Regulation of protein synthesis and degradation during in vitro cardiac work, Am. J. Physiol., 238:E431.PubMedGoogle Scholar
  7. Morgan, H. E., Earl, D. C. N., Broadus, A., Wolpert, E. B., Giger, K. E., and Jefferson, L. S., 1971a, Regulation of protein synthesis in heart muscle. I. Effect of amino acid levels on protein synthesis, J. Biol. Chem., 246:2152.PubMedGoogle Scholar
  8. Morgan, H. E., Jefferson, L. S., Wolpert, E. B., and Rannels, D. E., 1971b, Regulation of protein synthesis in heart muscle. II. Effect of amino acids and insulin on ribosomal aggregation, J. Biol. Chem., 246:2163.PubMedGoogle Scholar
  9. Neely, J. R. , Liebermeister, H., Battersby, E. J., and Morgan, H. E., 1967, Effect of pressure development on oxygen consumption by isolated rat heart, Am. J. Physiol., 212:804.PubMedGoogle Scholar
  10. Opie, L. H. , 1965, Coronary flow rate and perfusion pressure as determinants of mechanical function and oxidative metabolism of isolated perfused rat heart, J. Physiol., 180:529.PubMedGoogle Scholar
  11. Peterson, M. B. , and Lesch, M. , 1972, Protein synthesis and amino acid transport in the isolated rabbit right ventricular papillary muscle, Circ. Res., 31:317.PubMedGoogle Scholar
  12. Schreiber, S. S., Hearse, D. J., Oratz, M., and Rothschild, M. A., 1977, Protein synthesis in prolonged cardiac arrest, J. Mol. Cell. Cardiol., 9:87.PubMedCrossRefGoogle Scholar
  13. Schreiber, S. S., Oratz, M., and Rothschild, M. A., 1966, Protein synthesis in the overloaded mammalian heart, Am. J. Physiol., 211:314.Google Scholar
  14. Schreiber, S. S., Rothschild, M. A., Evans, C, Reff, F., and Oratz, M. , 1975, The effect of pressure or flow stress on right ventricular protein synthesis in the face of constant and restricted coronary perfusion, J. Clin. Invest., 55:1.PubMedCrossRefGoogle Scholar
  15. Takala, T., 1981, Protein synthesis in the isolated perfused rat heart, Basic Res. Cardiol., 76:44.PubMedCrossRefGoogle Scholar
  16. Waterlow, J. C. , Garlick, P. J., and Millward, D. J., 1978, “Protein Turnover in Mammalian Tissues and in the Whole Body,” North Holland, New York.Google Scholar
  17. Williams, I. H., Chua, B. H. L. , Sahms, R. H. , Siehl, D. , and Morgan, H. E., 1980, Effects of diabetes on protein turnover in cardiac muscle, Am. J. Physiol., 239:E178.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Yuji Kira
    • 1
  • Pamela Kochel
    • 1
  • Howard E. Morgan
    • 1
  1. 1.Department of Physiology, The Milton S. Hershey Medical CenterThe Pennsylvania State UniversityHersheyUSA

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