Aortic Perfusion Pressure and Protein Synthesis
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Cardiac hypertrophy is a compensatory mechanism utilized when the heart must do additional work. Immediately after imposition of an increased pressure load, an acceleration in the rate of protein synthesis must depend upon increased efficiency because sufficient time has not elapsed to allow for synthesis of increased numbers of ribosomes and other components of the pathway. Efficiency of synthesis refers to the rate at which amino acids are incorporated into protein when expressed as a function of tissue RNA, whereas capacity refers to the quantity of RNA present within the heart (Waterlow et al., 1978). When the effects of increased pressure load were studied in vitro, incorporation of amino acids into heart protein was accelerated by higher work loads in working heart preparations or by increased perfusion pressure in Langendorff preparations (Schreiber et al., 1966; Hjalmarson and Isaksson, 1972a; Morgan et al., 1980). In these circumstances, increased synthesis was thought to be related to development of higher levels of ventricular pressure.
KeywordsProtein Synthesis Perfusion Pressure Aortic Pressure Myocardial Oxygen Consumption Coronary Perfusion Pressure
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