Release of Superoxide and Hydrogen Peroxide from Guinea-Pig Alveolar Macrophages during Phagocytosis of Mycobacterium Bovis BCG

Jackett, P. S.; Andrew, P. W.; Lowrie, D. B.

doi:10.1007/978-1-4684-4394-3_75

P. S. Jackett³,
P. W. Andrew³ &
D. B. Lowrie³

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 155))

108 Accesses
2 Citations

Abstract

Experimental evidence is accumulating to suggest that macrophages can kill tubercle bacilli by producing hydrogen peroxide. For example, among strains of Mycobacterium tuberculosis virulence correlates with hydrogen peroxide resistance (1,2) and peroxide-susceptible mutants are killed more readily than parent strains in the lungs of guinea-pigs, particularly when the availability of peroxide from macrophages increases with the onset of acquired immunity (3,4). Furthermore, killing of Mycobacterium microti by immunologically-activated mouse peritoneal macrophages is prevented by exogenous catalase (5). This study characterizes hydrogen peroxide release from guinea-pig alveolar macrophages during phagocytosis of Mycobacterium bovis BCG.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

eBook: USD 16.99; Price excludes VAT (USA)

Softcover Book: USD 109.99; Price excludes VAT (USA)

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

References

Mitchison, D. A., Selkon, J. B., and Lloyd, J., J. Path. Bact. 86:377, 1963.
Article PubMed CAS Google Scholar
Jackett, P. S., Aber, V. R., and Lowrie, D. B., J. Gen. Microbiol. 104:37, 1968.
Google Scholar
Jackett, P. S., Aber, V. R., Mitchison, D. A., and Lowrie, D. B., Br. J. Exp. Path. 62:34, 1981.
CAS Google Scholar
Jackett, P. S., Andrew, P. W., Aber, V. R., and Lowrie, D. B., Br. J. Exp. Path. 62:419, 1981.
CAS Google Scholar
Walker, L., and Lowrie, D. B., Nature 293:69, 1981.
Article PubMed CAS Google Scholar
Labarca, C., and Paigen, K., Anal. Biochem. 102:344, 1980.
Article PubMed CAS Google Scholar
Armstrong, J. A., and Hart, P.D’A., J. Exp. Med. 142:1, 1975.
Article PubMed CAS Google Scholar
Lowrie, D. B., Jackett, P. S., Aber, V. R., and Carrol, M. E. W., in “Mononuclear Phagocytes: Functional Aspects” (R. van Furth, ed.), pp. 1057–1075, Martinus Nijhoff, The Hague, Boston, London, 1980.
Google Scholar

Download references

Author information

Authors and Affiliations

M. R. C. Unit for Laboratory Studies of Tuberculosis, Royal Postgraduate Medical School, London, W12 OHS, UK
P. S. Jackett, P. W. Andrew & D. B. Lowrie

Authors

P. S. Jackett
View author publications
You can also search for this author in PubMed Google Scholar
P. W. Andrew
View author publications
You can also search for this author in PubMed Google Scholar
D. B. Lowrie
View author publications
You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

College of Medicine, University of Florida, Gainesville, Florida, USA
Sigurd J. Normann
Department of Medicine, Swiss Research Institute, Davos, Switzerland
Ernst Sorkin

Rights and permissions

Reprints and permissions

Copyright information

About this chapter

Cite this chapter

Jackett, P.S., Andrew, P.W., Lowrie, D.B. (1982). Release of Superoxide and Hydrogen Peroxide from Guinea-Pig Alveolar Macrophages during Phagocytosis of Mycobacterium Bovis BCG. In: Normann, S.J., Sorkin, E. (eds) Macrophages and Natural Killer Cells. Advances in Experimental Medicine and Biology, vol 155. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4394-3_75

Download citation

DOI: https://doi.org/10.1007/978-1-4684-4394-3_75
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-4396-7
Online ISBN: 978-1-4684-4394-3
eBook Packages: Springer Book Archive

Publish with us

Policies and ethics