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Immunological Surveillance Versus Immunological Stimulation of Oncogenesis- a Formal Proof of the Stimulation Hypothesis

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Macrophages and Natural Killer Cells

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 155))

Abstract

When I was first introduced to cancer research in 1949, the immune mechanism was characterized by the attributes of specificity and memory, and the function of the thymus was unknown. We now have some knowledge of the role of the thymus and the definition of an immune reaction seems to have undergone a radical change. For example, a cell of the lymphoid family that has little specificity and is apparently unassociated with any form of memory, the so-called NK cell, is now promoted as the possible agent of immunological surveillance. Apparently, any function of any leucocyte is now deemed to be immunologic regardless of questions of specificity or memory.

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Author information

Authors and Affiliations

  1. Institute for Medical Research, 751 South Bascom Avenue, San Jose, California, 95128, USA

    Richmond T. Prehn

Authors
  1. Richmond T. Prehn
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Editor information

Editors and Affiliations

  1. College of Medicine, University of Florida, Gainesville, Florida, USA

    Sigurd J. Normann

  2. Department of Medicine, Swiss Research Institute, Davos, Switzerland

    Ernst Sorkin

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© 1982 Plenum Press, New York

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Prehn, R.T. (1982). Immunological Surveillance Versus Immunological Stimulation of Oncogenesis- a Formal Proof of the Stimulation Hypothesis. In: Normann, S.J., Sorkin, E. (eds) Macrophages and Natural Killer Cells. Advances in Experimental Medicine and Biology, vol 155. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4394-3_6

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  • DOI: https://doi.org/10.1007/978-1-4684-4394-3_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4396-7

  • Online ISBN: 978-1-4684-4394-3

  • eBook Packages: Springer Book Archive

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