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Prostaglandin E2 is a Feed-Back Regulator of Macrophage Activation

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Macrophages and Natural Killer Cells

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 155))

Abstract

Phagocytosis is a main function of macrophages and a powerful stimulus of macrophage differentiation (1). When quiescent macrophages are induced to phagocytose, a number of immediate responses are observed: (a) respiratory burst with release of Superoxide and H2O2; (b) release of arachidonic acid oxygenation products (3) and (c) secretion of lysosomal hydrolases (1,4). The delayed consequence of phagocytosis is a differentiation or activation process characterized by an increased production of cellular and export proteins that result in cell growth and the expression of novel secretory functions.

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References

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Author information

Authors and Affiliations

  1. Wander Research Institute, a Sandoz research unit Wander Ltd., P. O. Box 2747, CH-3001, Berne, Switzerland

    Jörg Schnyder, Beatrice Dewald & Marco Baggiolini

Authors
  1. Jörg Schnyder
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  2. Beatrice Dewald
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  3. Marco Baggiolini
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Editor information

Editors and Affiliations

  1. College of Medicine, University of Florida, Gainesville, Florida, USA

    Sigurd J. Normann

  2. Department of Medicine, Swiss Research Institute, Davos, Switzerland

    Ernst Sorkin

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© 1982 Plenum Press, New York

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Schnyder, J., Dewald, B., Baggiolini, M. (1982). Prostaglandin E2 is a Feed-Back Regulator of Macrophage Activation. In: Normann, S.J., Sorkin, E. (eds) Macrophages and Natural Killer Cells. Advances in Experimental Medicine and Biology, vol 155. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4394-3_57

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  • DOI: https://doi.org/10.1007/978-1-4684-4394-3_57

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4396-7

  • Online ISBN: 978-1-4684-4394-3

  • eBook Packages: Springer Book Archive

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