The Role of the Inflammatory Response During Tumor Growth

  • Robert Evans
  • Lawrence G. Eidlen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 155)


When tumor cells are injected into a syngeneic recipient, an inflammatory response occurs at the site of injection (1). The sequence of events and the types of cells entering the lesion are fairly typical of that seen during wound healing (2). Both tumor growth and wound healing involve changes in blood vessel permeability, as well as proliferation of vascular endothelial cells, influx of leukocytes and plasma constituents, and proliferation of cells such as fibroblasts and epithelial cells. In both situations these reactions probably involve the release of vasoactive amines (by platelets and mast cells), arachidonic acid or prostaglandins (by macrophages, mast cells and perhaps tumor cells), activation of the complement, coagulation, fibrinolytic and kinin systems, and the release of mediators controlling or stimulating cellular proliferation. It has been reported in tumor model systems (3) and during wound healing (2) that prevention of macrophage infiltration at the site may result in impaired growth or repair, implying an important role for macrophages in these reactions.


Tumor Growth Mast Cell Tissue Culture Cell Monocyte Count Enhance Tumor Growth 
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  1. 1.
    Evans, R., J. Reticuloendothelial Soc. 26:429, 1979.Google Scholar
  2. 2.
    Leibovitch, J. T., and Ross, R., Amer. J. Pathol. 78:71, 1975.Google Scholar
  3. 3.
    Evans, R., Brit. J. Cancer 37:1086, 1978.PubMedCrossRefGoogle Scholar
  4. 4.
    Evans, R., and Eidlen, D. M., J. Reticuloendothelial Soc. 301:425, 1981.Google Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Robert Evans
    • 1
  • Lawrence G. Eidlen
    • 1
  1. 1.Jackson LaboratoryBar HaborUSA

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