Abstract
Knowledge about the secretory repertoire of macrophages is expanding very rapidly. Many molecules have been identified as products of these cells, and it may sound old-fashioned to keep talking about lytic enzymes. Due to their ability to degrade a great variety of biological molecules, however, the secretory enzymes of macrophages are a major factor in many pathological processes. Two types of effects are particularly important: tissue damage resulting from the breakdown of extracellular connective tissue structures and the conditioning of the pericellular environment. Lytic enzymes are also useful experimental parameters. They are among the best-defined truly secretory molecules of the macrophage and are easy to assay. For this reason, the rate of secretion of certain hydrolases is often adopted as a marker of macrophage function.
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Baggiolini, M., Schnyder, J. (1982). Synthesis and Release of Lytic Enzymes by Macrophages in Chronic Inflammation. In: Normann, S.J., Sorkin, E. (eds) Macrophages and Natural Killer Cells. Advances in Experimental Medicine and Biology, vol 155. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4394-3_31
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DOI: https://doi.org/10.1007/978-1-4684-4394-3_31
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