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Regulation of Macrophage Production

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Macrophages and Natural Killer Cells

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 155))

Abstract

In parallel with the production of other hemopoietic cells, macrophage production is continuous throughout adult life. As shown in Figure 1, the production of tissue macrophages is the end result of a sequential series of events in which, (a) multipotential stem cells (colony forming units, spleen, CFU-S) generate progenitor cells committed to granulocyte and monocyte production (GM-colony forming cells, GM-CFC), (b) individual progenitor cells generate clones of progeny cells that progressively lose the capacity for further division and generate maturing monocytes, (c) monocytes are released to the circulation from the marrow and spleen, (d) circulating monocytes seed in the tissues either to die or to form relatively long-lived tissue macrophages, some of which have a limited proliferative capacity and (e) limited recirculation of tissue macrophages occurs between different organs.

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References

  1. Till, J. E., and McCulloch, E. A., Rad. Res. 19:213, 1961.

    Article  Google Scholar 

  2. Johnson, G. R., and Metcalf, D., Proc. Natl. Acad. Sci. USA 74:3879, 1977.

    Article  PubMed  CAS  Google Scholar 

  3. Johnson, G. R., J. Cell. Physiol. 103:371, 1980.

    Article  PubMed  CAS  Google Scholar 

  4. Bradley, T. R., and Metcalf, D., Aust. J. Exp. Biol. Med. Sci. 44:287, 1966.

    Article  PubMed  CAS  Google Scholar 

  5. Ichikawa, Y., Pluznik, D. H., and Sachs, L., Proc. Natl. Acad. Sci.USA 56:488, 1966.

    Article  PubMed  CAS  Google Scholar 

  6. Metcalf, D., “Hemopoietic Colonies. In vitro Cloning of Normal and Leukemic Cells,” Springer-Verlag, Heidelberg, New York, 1977.

    Google Scholar 

  7. Van Furth, R., Goud, T. J. C. M., and Van Waarde, D., in “Experimental Hematology Today 1978” (S.J. Baum and G. D. Ledney, eds.), pp. 65–71, Springer-Verlag, New York, 1978.

    Google Scholar 

  8. Volkman, A., and Gowans, J. C., Brit. J. Exp. Path. 46:50, 1965.

    PubMed  CAS  Google Scholar 

  9. Ryan, G. B., and Spector, W. G., Proc. Roy. Soc. B 175:269, 1970.

    Article  Google Scholar 

  10. Roser, B., Aust. J. Exp. Biol. Med. Sci. 43:553, 1965,.

    Article  PubMed  CAS  Google Scholar 

  11. Athens, J. W., Natl. Cancer Instit. Monograph 30:135, 1969.

    CAS  Google Scholar 

  12. Staber, F. G., and Johnson, G. R., J. Cell. Physiol. 105:143, 1980.

    Article  PubMed  CAS  Google Scholar 

  13. Staber, F. G., and Metcalf, D., Proc. Natl. Acad. Sci USA 77:4322, 1980.

    Article  PubMed  CAS  Google Scholar 

  14. Testa, N. G., and Hendry, J. H., Exp. Hematol. 5:136, 1977.

    PubMed  CAS  Google Scholar 

  15. Hays, E. F., Firkin, F. C., Koga, Y., and Hays, M., J. Cell Physiol. 86:213, 1975.

    Article  PubMed  CAS  Google Scholar 

  16. Moore, M. A. S., and Williams, N., Cell Tissue Kinet. 6:431, 1973.

    Google Scholar 

  17. Johnson, G. R., and Metcalf, D., in “Differentiation of Normal and Neoplastic Hematopoietic Cells” (B. Clarkson and R. Baserga, eds.), pp. 49–62, Cold Spring Harbor: Cold Spring Harbor Laboratory, 1978.

    Google Scholar 

  18. Johnson, G. R., and Metcalf, D., Exp. Hematol. 6:246, 1978.

    PubMed  CAS  Google Scholar 

  19. Lord, B. I., Mori, K. J., Wright, E. G., and Lajtha, L. J., Brit. J. Haematol. 34:441, 1976.

    Article  CAS  Google Scholar 

  20. Ghio, R., Bianchi, G., Lowenberg, B., Dicke, K. A., and Ajmar, J., Exp. Hematol. 5:341, 1979.

    Google Scholar 

  21. Wagemaker, G., in “Hemopoietic Cell Differentiation” (D. W. Golde, M. J. Cline, D. Metcalf and C. F. Fox, eds.), pp. 109–118, Academic Press, New York, 1978.

    Google Scholar 

  22. Wagemaker, G., and Peters, M. F., Cell Tissue Kinet. 11:45, 1978.

    PubMed  CAS  Google Scholar 

  23. Frindel, E., in “Stem Cells, Cell Lineages and Cell Determination” (N. Le Douarin, ed.), pp. 227–239, Elsevier/North Holland, Amsterdam, 1979.

    Google Scholar 

  24. Staber, F. G., and Metcalf, D., Exp. Hematol. 8:1094, 1980.

    PubMed  CAS  Google Scholar 

  25. Staber, F. G., and Burgess, A. W., J. Cell. Physiol. 102:1, 1980.

    Article  PubMed  CAS  Google Scholar 

  26. Till, J. E., McCulloch, E. A., and Siminovitch, L., Proc. Natl. Acad. Sci. USA 51:29, 1964.

    Article  PubMed  CAS  Google Scholar 

  27. Johnson, G. R., in “Experimental Hematology Today” (S. J. Baum, G. D. Ledney and A. Kahn, eds.), pp. 13–20, Karger, Basel, 1981.

    Google Scholar 

  28. Trentin, J. J., in “Regulation of Hematopoiesis” (A. S. Gordon, ed.), pp. 161–186, Appleton-Century-Crofts, New York, 1970.

    Google Scholar 

  29. Metcalf, D., and Moore, M. A. S., “Haemopoietic Cells,” North Holland, Amsterdam, 1971.

    Google Scholar 

  30. Johnson, G. R., and Metcalf, D., in “Stem Cells, Cell Lineages and Cell Determination” (N. Le Douarin, ed.), pp. 199–213, Elsevier/North Holland, Amsterdam, 1979.

    Google Scholar 

  31. Gregory, C. J., and Henkelmann, R. M., in “Experimental Hematology Today” (S. J. Baum and G. D. Ledney, eds.), pp. 93–101, Springer-Verlag, New York, 1977.

    Google Scholar 

  32. Metcalf, D., Johnson, G. R., and Mandel, T. E., J. Cell. Physiol. 98:401, 1979.

    Article  PubMed  CAS  Google Scholar 

  33. Humphries, R. K., Jacky, P. B., Dill, F. J., Eaves, A. C., and Eaves, C. J., Nature 279:718, 1979.

    Article  PubMed  CAS  Google Scholar 

  34. Metcalf, D., in “Clinics in Haematology”, 8:263, Saunders, London, 1979.

    PubMed  CAS  Google Scholar 

  35. Nicola, N. A., Burgess, A. W., Johnson, G. R., Metcalf, D., and Battye, F. L., J. Cell. Physiol. 103:217, 1980.

    Article  PubMed  CAS  Google Scholar 

  36. Metcalf, D., and MacDonald, H. R., J. Cell. Physiol. 85:643, 1975.

    Article  PubMed  CAS  Google Scholar 

  37. Byrne, P., Heit, W., and Kubanek, B., Cell Tissue Kinet. 10:341, 1977.

    PubMed  CAS  Google Scholar 

  38. Bol, S., Visser, J., and van den Engh, G. J., Exp. Hematol. 7:541, 1979.

    PubMed  CAS  Google Scholar 

  39. Metcalf, D., and Burgess, A. W., J. Cell. Physiol. in press, 1981.

    Google Scholar 

  40. Bol, S., and Williams, N., J. Cell. Physiol. 102:233, 1980.

    Article  PubMed  CAS  Google Scholar 

  41. Metcalf, D., Johnson, G. R., and Burgess, A. W., Blood 55:138, 1980.

    PubMed  CAS  Google Scholar 

  42. Guilbert, L. J., and Iscove, N. N., Nature 263:594, 1976.

    Article  PubMed  CAS  Google Scholar 

  43. Metcalf, D., J. Cell. Physiol. 76:89, 1970.

    Article  PubMed  CAS  Google Scholar 

  44. Metcalf, D., and Merchav, S., J. Cell. Physiol., in press, 1982.

    Google Scholar 

  45. Moore, M. A. S., and Williams, N., In “Hemopoiesis in Culture” (W. A. Robinson, ed.), pp. 16–26, DHEW Publication No. (NIH) 74-205, Washington, 1973.

    Google Scholar 

  46. Metcalf, D., Proc. Natl. Acad. Sci. USA 77:5327, 1980.

    Article  PubMed  CAS  Google Scholar 

  47. Burgess, A. W., and Metcalf, D., in “Experimental Hematology Today” (S. J. Baum and G. D. Ledney, eds.), pp. 135–146, Springer-Verlag, Heidelberg, New York, 1977.

    Google Scholar 

  48. Moore, M. A. S., Spitzer, G., Metcalf, D., and Penington, D. G., Brit. J. Haematol. 27:47, 1974.

    Article  CAS  Google Scholar 

  49. Stanley, E. R., Cifone, M., Heard, P. M., and Defendi, V., J. Exp. Med. 143:631, 1976.

    Article  PubMed  CAS  Google Scholar 

  50. Stanley, E. R., and Heard, P. M., J. Biol. Chem. 252:4305, 1977.

    PubMed  CAS  Google Scholar 

  51. Burgess, A. W., Camakaris, J., and Metcalf, D., J. Biol. Chem. 252:1998, 1977.

    PubMed  CAS  Google Scholar 

  52. Shadduck, R. K., and Metcalf, D., J. Cell. Physiol. 86:247, 1975.

    Article  PubMed  CAS  Google Scholar 

  53. Stanley, E. R., Proc. Natl. Acad. Sci. USA 76:2969, 1979.

    Article  PubMed  CAS  Google Scholar 

  54. Nicola, N. A., Burgess, A. W., and Metcalf, D., J. Biol Chem. 254:5290, 1979.

    PubMed  CAS  Google Scholar 

  55. Burgess, A. W., and Metcalf, D., Int. J. Cancer 26:647, 1980.

    Article  PubMed  CAS  Google Scholar 

  56. Lotem, J., Lipton, J. H., and Sachs, L., Int. J. Cancer 25:763, 1980.

    Article  PubMed  CAS  Google Scholar 

  57. Nicola, N. A., and Metcalf, D., J. Cell. Physiol. 109:253, 1981.

    Article  PubMed  CAS  Google Scholar 

  58. Johnson, G. R., and Burgess, A. W., J. Cell. Biol. 77:35, 1978.

    Article  PubMed  CAS  Google Scholar 

  59. Horiuchi, M., and Ichikawa, Y., Exp. Cell Res. 110:79, 1977.

    Article  PubMed  CAS  Google Scholar 

  60. Metcalf, D., Merchav. S., and Wagemaker, G., in “Experimental Hematology Today 1982” (S. J. Baum, ed.), Karger, Basel, in press, 1982.

    Google Scholar 

  61. McNeill, T. A., and Fleming, W. A., J. Cell. Physiol. 82:49, 1973.

    Article  PubMed  CAS  Google Scholar 

  62. Chan, S. H., Aust. J. Exp. Biol. Med. Sci. 49:553, 1971.

    Article  Google Scholar 

  63. Chan, S. E., Metcalf, D., and Stanley, E. R., Brit. J. Haematol. 20:329, 1971.

    Article  CAS  Google Scholar 

  64. Metcalf, D., and Russell, S., Exp. Hematol. 4:339, 1976.

    PubMed  CAS  Google Scholar 

  65. Paukovits, W. R., and Hinterberger, W., Blut 37:7, 1978.

    Article  PubMed  CAS  Google Scholar 

  66. Aardal, N. P., Laerum, O. D., Paukovits, W. R., and Mauer, H. R., Virchows Archiv (Cell Pathol.) 24:27, 1977.

    CAS  Google Scholar 

  67. Williams, N., Blood 53:1089, 1979.

    PubMed  CAS  Google Scholar 

  68. Peius, L. M., Broxmeyer, H. E., Kurland, J. I., and Moore, M. A. S., J. Exp. Med. 150:277, 1979.

    Article  Google Scholar 

  69. Chang, C. F., and Pollard, M., Proc. Soc. Exp. Biol. Med. 144:177, 1973.

    PubMed  CAS  Google Scholar 

  70. Foster, R., Metcalf, D., and Kirchmyer, R., J. Exp. Med. 127:853, 1968.

    Article  PubMed  Google Scholar 

  71. Trudgett, A., McNeill, A., and Killen, M., Infect. Immunol. 8:450, 1973.

    CAS  Google Scholar 

  72. Bro-Jorgensen, K., and Knudtzon, S., Blood 49:57, 1977.

    Google Scholar 

  73. Metcalf, D., Immunology 21:427, 1971.

    PubMed  CAS  Google Scholar 

  74. Quesenberry, P., Morley, A., Stohlman, F., Rickard, K., Howard, D., and Smith, M., New Engl. J. Med. 286:227, 1972.

    Article  PubMed  CAS  Google Scholar 

  75. Staber, F. G., Gisler, R. H., Schumann, G., Tarcsay, L., Schlafli, E., and Dukor, P., Cell. Immunol. 37:174, 1978.

    Article  PubMed  CAS  Google Scholar 

  76. Singer, J. W., James, M. C., and Thomas, E. D., in “Experimental Hematology Today” (S. J. Baum and G. D. Ledney, eds.), pp. 221–231, Springer-Verlag, Heidelberg, New York, 1977.

    Google Scholar 

  77. Hara, H., Kitamura, Y., Kawata, T., Kanamura, A., and Nagai, K., Exp. Hematol. 2:43, 1974.

    PubMed  CAS  Google Scholar 

  78. Chan, S. H., and Metcalf, D., Cell Tissue Kinet. 6:185, 1973.

    PubMed  CAS  Google Scholar 

  79. Austin, P. E., McCulloch, E. A., and Till, J. E., J. Cell. Physiol. 77:121, 1971.

    Article  PubMed  CAS  Google Scholar 

  80. McNeill, T. A., Nature 244:175, 1973.

    CAS  Google Scholar 

  81. Parker, J. W., and Metcalf, D., J. Immunol. 112:502, 1974.

    PubMed  CAS  Google Scholar 

  82. Quesenberry, P., and Gimbrone, M. A., Blood 56:1060, 1980.

    PubMed  CAS  Google Scholar 

  83. Moore, M. A. S., and Williams, N., J. Cell. Physiol. 80:195, 1972.

    Article  PubMed  CAS  Google Scholar 

  84. Chervenick, P. A., and Lo Buglio, A. F., Science 178:164, 1972.

    Article  PubMed  CAS  Google Scholar 

  85. Golde, D. W., and Cline, M. J., J. Clin. Investigation 52:2981, 1972.

    Article  Google Scholar 

  86. Sheridan, J. W., and Metcalf, D., in “Hemopoiesis in Culture” (W. A. Robinson, ed.), p. 135, DHEW Publication No. (NIH) 74-205, Washington, 1973.

    Google Scholar 

  87. Kurland, H. I., Broxmeyer, H. E., Peius, L. M., Bookman, R. S., and Moore, M. A. S., Blood 52:388, 1978.

    PubMed  CAS  Google Scholar 

  88. Eaves, A. C., and Bruce, W. R., Cell Tissue Kinet. 7:19, 1974.

    PubMed  CAS  Google Scholar 

  89. Chervenick, P., and Boggs, D. R., Blood 37:131, 1971.

    PubMed  CAS  Google Scholar 

  90. Dresch, C., Johnson, G. R., and Metcalf, D., Blood 49:835, 1977.

    PubMed  CAS  Google Scholar 

  91. Nicola, N. A., Metcalf, D., Johnson, G. R., and Burgess, A. W., Blood 54:614, 1979.

    PubMed  CAS  Google Scholar 

  92. Broxmeyer, H. E., Smithyman, A., Eger, R. R., Meyers, P. A., and de Sousa, M., J. Exp. Med. 148:1052, 1978.

    Article  PubMed  CAS  Google Scholar 

  93. Broxmeyer, H. E., Bognacki, J., Dorner, M. H., de Sousa, M., and Lu, L., in “Modern Trends in Human Leukemia IV” (R. Neth, R. C. Gallo, T. Graf, K. Mannweiler and K. Winkler, eds.), pp. 243–245, Springer-Verlag, Berlin, 1981.

    Chapter  Google Scholar 

  94. Lin, H-S., and Stewart, C. C., J. Cell. Physiol. 83:369, 1974.

    Article  PubMed  CAS  Google Scholar 

  95. Lin, H-S., Blood 49:593, 1977.

    PubMed  CAS  Google Scholar 

  96. Chen, D-M., Lin, H-S., Stahl, P., and Stanley, E. R., Exp. Cell Res. 121:103, 1979.

    Article  PubMed  CAS  Google Scholar 

  97. Ledney, G. D., MacVittie, T. J., Stewart, D. A., and Parker, G. A., in “Experimental Hematology Today 1978” (S. J. Baum and G. D. Ledney, eds.), pp. 73–84, Springer-Verlag, New York, 1978.

    Google Scholar 

  98. Forbes, I. J., and Mackaness, G. B., Lancet 2:1203, 1963.

    Article  PubMed  CAS  Google Scholar 

  99. Burgess, A. W., and Metcalf, D., J. Cell. Physiol. 90:471, 1977.

    Article  PubMed  CAS  Google Scholar 

  100. Handman, E., and Burgess, A. W., J. Immunol. 122:1134, 1979.

    PubMed  CAS  Google Scholar 

  101. Lin, H-S., and Gordon, S., J. Exp. Med. 150:231, 1979.

    Article  PubMed  CAS  Google Scholar 

  102. Krantz, S. B., Gallien-Lartigue, O., and Goldwasser, E., J. Biol. Chem. 238:4085, 1963.

    CAS  Google Scholar 

  103. Vadas, M., Dessein, A., Nicola, N. A., and David, J. R., Aust. J. Exp. Biol. Med. Sci. 59:739, 1981.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Cancer Research Unit The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria, 3050, Australia

    Donald Metcalf

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  1. Donald Metcalf
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Editors and Affiliations

  1. College of Medicine, University of Florida, Gainesville, Florida, USA

    Sigurd J. Normann

  2. Department of Medicine, Swiss Research Institute, Davos, Switzerland

    Ernst Sorkin

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Metcalf, D. (1982). Regulation of Macrophage Production. In: Normann, S.J., Sorkin, E. (eds) Macrophages and Natural Killer Cells. Advances in Experimental Medicine and Biology, vol 155. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4394-3_3

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  • DOI: https://doi.org/10.1007/978-1-4684-4394-3_3

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