Advertisement

Selection of an Immunogenic 3LL Tumor Subline Following Serial Growth In Vivo in the Local Presence of Peritoneal Macrophages

  • Patrick De Baetselier
  • Ahuva Kapon
  • Shulamit Katsav
  • Michael Feldman
  • Shraga Segal
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 155)

Abstract

Macrophages may play a role in host defense against neoplasia since they inhibit the growth of tumors at primary (1) and metastatic sites (2). In contrast, some reports indicate that macrophages may promote tumor development in several ways such as induction of clonal proliferation of malignant cells (3) or activation of tumor mediated suppressor mechanisms (4). The diverse and of ten contradictory effects of macrophages can be explained by the functional heterogeneity of macrophage populations (5).

Keywords

Peritoneal Macrophage Experimental Metastasis Thymidine Uptake Local Presence Spontaneous Metastasis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Den Otter, W., Dullens Hub, F. S., Van Lovern, H., and Pels, E., in “The Macrophage and Cancer” (K. James, B. McBride, and A. Stuart, eds.), P. 119, Econoprint, Edinburgh, 1977.Google Scholar
  2. 2.
    Fidler, I. S., Cancer Res. 34:1074, 1974.PubMedGoogle Scholar
  3. 3.
    Schultz, R. M., Chirigos, M. A., and Olkowski, Z. I., Cellular Immunology 54:98, 1980.PubMedCrossRefGoogle Scholar
  4. 4.
    Ting, C., and Rodrigues, D., Proc. Natl. Acad. Sci. USA 77:4265, 1980.PubMedCrossRefGoogle Scholar
  5. 5.
    Tzehoval, E., De Baetselier, P., Feldman, M., and Segal, S., Eur. J. Immunology 11:323, 1981.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Patrick De Baetselier
    • 1
    • 2
  • Ahuva Kapon
    • 1
    • 2
  • Shulamit Katsav
    • 1
    • 2
  • Michael Feldman
    • 1
    • 2
  • Shraga Segal
    • 1
    • 2
  1. 1.Instituut voor Moleculaire BiologieSint-Genesius-RodeBelgium
  2. 2.Department of Cell BiologyWeizmann Institute of ScienceRehovotIsrael

Personalised recommendations